Post-modern Medicolegal and Forensic Toxicology
The ongoing progress in analytical and life sciences is opening up new perspectives in post-modern medico-legal and forensic toxicology. In times of personalized medicine, the interpretation of analytical results in clinical and forensic cases should also be based on genetic aspects, pharmacogenomics in particular. Pharmacologic and toxic effects of drugs or poisons may be influenced by the genotype and phenotype of an individual, but also by the isoenzymes involved in their metabolism and membrane transport. Further individual factors such as body mass, age, sex, kidney and liver function, and drug-drug (food-drug) interactions may have an impact. Detailed knowledge of all these factors is a prerequisite for evidence-based case interpretation. In this chapter, the current knowledge of possible risks in variations of the effects of relevant therapeutic drugs, herbal drugs, and drugs of abuse will be presented. A critical discussion of the impact on the interpretation of analytical results in clinical and forensic toxicology will follow.
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