Review Chapter: Fusarium Genus and Essential Oils

  • Martin Zabka
  • Roman Pavela
Part of the Sustainable Development and Biodiversity book series (SDEB, volume 19)


The Fusarium genus belongs to the most significant fungi genera on earth. Enumeration of the large number of its importance aspects is beyond the means of one scientific discipline. Similarly, it comprises a huge group of many organisms, which are currently considered from many taxonomic viewpoints, in the light of developing modern methods and fungal taxonomy. The Fusarium genus includes a large number of species, which are pathogenic not only for plants, but also humans or livestock, where they cause local and systemic mycosis dangerous to life. In agriculture and plant protection, many species of the Fusarium genus constitute an enormous problem with huge economic impacts on plant and food production. One of the most dangerous properties is considered as the capability to produce chemically variegated and mostly extremely dangerous secondary toxic metabolites, which are known commonly as Fusarium mycotoxins. It is the Fusarium mycotoxins, which rank among the most dangerous mycotoxins. In conventional agricultural practice, but also in the treatment of human mycosis, elaborate strategies for fungicidal treatment exist that use synthetic fungicides. Thanks to the increasing number of cases of fungal resistance to synthetic fungicides and problems with residues in the ecosystem, the popularity of research in alternative and natural protection methods is increasing. Essential oils (EOs) are an excellent alternative based on natural mixtures and biodegradable substances of natural origin. The next chapter discusses the problems of fusaria from the above-mentioned aspects and includes the summary of research results published to date in the area of effect of EOs on the most common species of the Fusarium genus.


Essential oils Fusarium Fusariosis Pathogenic fungi Toxigenic fungi Antifungals Phenols Terpenes Mycosis Mycotoxins 



This review was supported by the Ministry of Agriculture of the Czech Republic (project QJ1510160).


  1. Agrios GN (1988) Plant pathology, 3rd edn. Academic Press Inc, New York, p 803Google Scholar
  2. Ahmad A, Khan A, Akhtar F, Yousuf S, Xess I, Khan LA, Manzoor N (2011) Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida. Eur J Clin Microbiol Infect Dis 30(1):41–50CrossRefPubMedGoogle Scholar
  3. Badawy ME, Abdelgaleil SA (2014) Composition and antimicrobial activity of essential oils isolated from Egyptian plants against plant pathogenic bacteria and fungi. Ind Crops Prod 52:776–782CrossRefGoogle Scholar
  4. Bajpai VK, Rahman A, Kang SC (2007) Chemical composition and anti-fungal properties of the essential oil and crude extracts of Metasequoia glyptostroboides Miki ex Hu. Ind Crops Prod 26(1):28–35CrossRefGoogle Scholar
  5. Bajpai VK, Shukla S, Kang SC (2008) Chemical composition and antifungal activity of essential oil and various extract of Silene armeria L. Bioresour Technol 99(18):8903–8908CrossRefPubMedGoogle Scholar
  6. Bajpai VK, Lee TJ, Kang SC (2009) Chemical composition and in vitro control of agricultural plant pathogens by the essential oil and various extracts of Nandina domestica Thunb. J Sci Food Agric 89(1):109–116CrossRefGoogle Scholar
  7. Bakkali F, Averbeck S, Averbeck D, Idaomar M (2008) Biological effects of essential oils—a review. Food Chem Toxicol 46:446–475CrossRefPubMedGoogle Scholar
  8. Banthorpe DV (1991) Classification of terpenoids and general procedures for their characterization. In: Charlwood BV, Banthorpe DV (eds) Methods in plant biochemistry, vol 7. Terpenoids. Academic, London, pp 1–41Google Scholar
  9. Bassole IH, Juliany R (2012) Essential oils in combination and her antimicrobial properties. Molecules 17:3989–4006CrossRefPubMedGoogle Scholar
  10. Ben Arfa A, Combes S, Preziosi-Belloy L, Gontard N, Chalier P (2006) Antimicrobial activity of carvacrol related to its chemical structure. Lett Appl Microbiol 43(2):149–154CrossRefPubMedGoogle Scholar
  11. Booth C (1984) The Fusarium problem: historical, economic and taxonomic aspects. In: Moss MO, Smith JE (eds) The applied mycology of Fusarium, pp 1–13Google Scholar
  12. Burt S (2004) Essential oils: their antibacterial properties and potential applications in foods - a review. Int J Food Microbiol 94:223–253CrossRefPubMedGoogle Scholar
  13. Cardiet G, Fuzeau B, Barreau C, Fleurat-Lessard F (2012) Contact and fumigant toxicity of some essential oil constituents against a grain insect pest Sitophilus oryzae and two fungi, Aspergillus westerdijkiae and Fusarium graminearum. J Pest Sci 85(3):351–358Google Scholar
  14. Christian EJ, Goggi AS (2008) Aromatic plant oils as fungicide for organic corn production. Crop Sci 48(5):1941–1951CrossRefGoogle Scholar
  15. Chutia M, Bhuyan PD, Pathak MG, Sarma TC, Boruah P (2009) Antifungal activity and chemical composition of Citrus reticulata Blanco essential oil against phytopathogens from North East India. LWT-Food Sci Technol 42(3):777–780CrossRefGoogle Scholar
  16. Costa LG, Giordano G, Guizzetti M, Vitalone A (2008) Neurotoxicity of pesticides: a brief review. Front Biosci 13:1240–1249CrossRefPubMedGoogle Scholar
  17. Crocker GB (1988) The “yellow rain” issue: evidence of chemical and toxin weapons use in Laos, Cambodia, and Afghanistan. Comments Toxicol 2(1):5–16Google Scholar
  18. Cus F, Cesnik HB, Bolta SV, Gregorcic A (2010) Pesticide residues in grapes and during vinification process. Food Control 21(11):1512–1518CrossRefGoogle Scholar
  19. da Silva Bomfim N, Nakassugi LP, Oliveira JFP, Kohiyama CY, Mossini SAG, Grespan R et al (2015) Antifungal activity and inhibition of fumonisin production by Rosmarinus officinalis L. essential oil in Fusarium verticillioides (Sacc.) Nirenberg. Food Chem 166:330–336CrossRefPubMedGoogle Scholar
  20. Desjardins AE (2006) Fusarium mycotoxins, chemistry, genetics, and biology. The American Phytopathological Society, St. Paul. MN, USA, p 268Google Scholar
  21. Desjardins AE, Plattner RD, Gordon TR (2000) Gibberella fujikuroi mating population A and Fusarium subglutinans from teosinte species and maize from Mexico and Central America. Mycol Res 104:865–872CrossRefGoogle Scholar
  22. Dubey NK (2011) Natural products in pest management. CAB International, LondonGoogle Scholar
  23. Džamić A, Soković M, Ristić M, Grujić-Jovanović S, Vukojević J, Marin PD (2008) Chemical composition and antifungal activity of Salvia sclarea (Lamiaceae) essential oil. Arch Biol Sci 60(2):233–237CrossRefGoogle Scholar
  24. El-Baroty GS, El-Baky HA, Farag RS, Saleh MA (2010) Characterization of antioxidant and antimicrobial compounds of cinnamon and ginger essential oils. Afr J Biochem Res 4(6):167–174Google Scholar
  25. El-Haci IA, Bekhechi C, Atik-Bekkara F, Mazari W, Gherib M, Bighelli A et al (2014) Antimicrobial activity of Ammodaucus leucotrichus fruit oil from Algerian Sahara. Nat Prod Commun 9(5):711–712PubMedGoogle Scholar
  26. Ellouze I, Abderrabba M, Sabaou N, Mathieu F, Lebrihi A, Bouajila J (2012) Season’s variation impact on Citrus aurantium leaves essential oil: chemical composition and biological activities. J Food Sci 77(9):T173–T180CrossRefPubMedGoogle Scholar
  27. European Commission Regulation No 1881/2006 Off J Eur Union L364:5–24Google Scholar
  28. Fahn A (2000) Structure and function of secretory cells. Adv Bot Res 31:37–75CrossRefGoogle Scholar
  29. Fandohan P, Gbenou JD, Gnonlonfin B, Hell K, Marasas WF, Wingfield MJ (2004) Effect of essential oils on the growth of Fusarium verticillioides and fumonisin contamination in corn. J Agric Food Chem 52(22):6824–6829CrossRefPubMedGoogle Scholar
  30. Farzaneh M, Ahmadzadeh M, Hadian J, Tehrani AS (2005) Chemical composition and antifungal activity of the essential oils of three species of Artemisia on some soil-borne phytopathogens. Commun Agric Appl Biol Sci 71(3 Pt B):1327–1333Google Scholar
  31. Frisvad JC, Samson RA (1991) Filamentous fungi in foods and feeds: ecology, spoilage, and mycotoxin production. In: Arora DK, Mukerjii KG, Marth EH (eds) Foods and feeds. Handbook of applied mycology, vol 3. Marcel Dekker, New York, U.S.A, pp 31–68Google Scholar
  32. Gherib M, Atik Bekkara F, Bekhechi C, Bighelli A, Casanova J, Tomi F (2014) Composition and antimicrobial activity of the essential oil from Algerian Warionia saharae Benth. & Hook. J Essent Oil Res 26(5):385–391CrossRefGoogle Scholar
  33. Gordon TR, Martyn RD (1997) The evolutionary biology of Fusarium oxysporum. Annu Rev Phytopathol 35:111–128CrossRefPubMedGoogle Scholar
  34. Goswami RS, Kistler HC (2004) Heading for disaster: Fusarium graminearum on cereal crops. Mol Plant Pathol 5(6):515–525CrossRefPubMedGoogle Scholar
  35. Grayson DH (2000) Monoterpenoids. Nat Prod Rep 17:385–419CrossRefPubMedGoogle Scholar
  36. Gubbins PO, Heldenbrand S (2010) Clinically relevant drug interactions of current antifungal agents. Mycoses 53(2):95–113CrossRefPubMedGoogle Scholar
  37. Hammami I, Smaoui S, Hsouna AB, Hamdi N, Triki MA (2015) Ruta montana L. leaf essential oil and extracts: characterization of bioactive compounds and suppression of crown gall disease. EXCLI J 14:83Google Scholar
  38. Hossain MA, Ismail Z, Rahman A, Kang SC (2008) Chemical composition and anti-fungal properties of the essential oils and crude extracts of Orthosiphon stamineus Benth. Ind Crops Prod 27(3):328–334CrossRefGoogle Scholar
  39. Hussain AI, Anwar F, Shahid M, Ashraf M, Przybylski R (2010) Chemical composition, and antioxidant and antimicrobial activities of essential oil of spearmint (Mentha spicata L.) from Pakistan. J Essent Oil Res 22(1):78–84CrossRefGoogle Scholar
  40. Jiang QT, Lee TKM, Chen K, Wong HL, Zheng JS, Giesy JP, Lo KKW, Yamashita N, Lam PKS (2005) Human health risk assessment of organochlorines associated with fish consumption in a coastal city in China. Environ Pollut 136(1):155–165CrossRefPubMedGoogle Scholar
  41. Kadri SS, Remy KE, Strich JR, Gea-Banacloche J, Leitman SF (2015) Role of granulocyte transfusions in invasive fusariosis: systematic review and single-center experience. Transfusion 55(9):2076–2085CrossRefPubMedPubMedCentralGoogle Scholar
  42. Kalemba D, Kunicka A (2003) Antibacterial and antifungal properties of essential oils. Curr Med Chem 10(10):813–829CrossRefPubMedGoogle Scholar
  43. Kulik T (2008) Detection of Fusarium tricinctum from cereal grain using PCR essay. J Appl Genet 49(3):305–311CrossRefPubMedGoogle Scholar
  44. Kumar A, Shukla R, Singh P, Anuradha DNK (2010) Efficacy of extract and essential oil of Lantana indica Roxb. against food contaminating moulds and aflatoxin B-1 production. Int J Food Sci Technol 45 (1):179–185Google Scholar
  45. López AG, Theumer MG, Zygadlo JA, Rubinstein HR (2004) Aromatic plants essential oils activity on Fusarium verticillioides Fumonisin B1 production in corn grain. Mycopathologia 158(3):343–349CrossRefPubMedGoogle Scholar
  46. Mirocha CJ, Pathre S (1973) Identification of the toxic principle in a sample of poaefusarin. Appl Microbiol 26:719–724PubMedPubMedCentralGoogle Scholar
  47. Mullin CA, Frazier M, Frazier JL, Ashcraft S, Simonds R, vanEngelsdorp D, Pettis JS (2010) High levels of miticides and agrochemicals in North Američan apiaries: implications for honey bee health. PLoS ONE 5(3):e9754CrossRefPubMedPubMedCentralGoogle Scholar
  48. Nakanishi T (2007) Potential toxicity of organotin compounds via nuclear receptor signaling in mammals. J Health Sci 53(1):1–9CrossRefGoogle Scholar
  49. Nucci M, Anaissie E (2007) Fusarium infections in immunocompromised patients. Clin Microbiol Rev 20(4):695–704CrossRefPubMedPubMedCentralGoogle Scholar
  50. Ooi LS, Li Y, Kam SL, Wang H, Wong EY, Ooi VE (2006) Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia Blume. Am J Chin Med 34(03):511–522CrossRefPubMedGoogle Scholar
  51. Philippe S, Souaïbou F, Jean-Pierre N, Brice F, Paulin A, Issaka Y, Dominique S (2012) Chemical composition and in vitro antifungal activity of Zingiber officinale essential oil against foodborne pathogens isolated from a traditional cheese wagashi produced in Benin. Int J Biosci (Ijb) 2(9):20–28Google Scholar
  52. Pinto E, Salgueiro LR, Cavaleiro C, Palmeira A, Gonçalves MJ (2007) In vitro susceptibility of some species of yeasts and filamentous fungi to essential oils of Salvia officinalis. Ind Crops Prod 26(2):135–141CrossRefGoogle Scholar
  53. Prakash B, Shukla R, Singh P, Kumar A, Mishra PK, Dubey NK (2010) Efficacy of chemically characterized Piper betle L. essential oil against fungal and aflatoxin contamination of some edible commodities and its antioxidant activity. Int J Food Microbiol 142:114–119CrossRefPubMedGoogle Scholar
  54. Prakash B, Kedia A, Mishra PK, Dubey NK (2015) Plant essential oils as food preservatives to control moulds, mykotoxin contamination and oxidative deterioration of agri-food commodities—potentials and challenges. Food Control 47:381–391CrossRefGoogle Scholar
  55. Pujol I, Aguilar C, Fernandez-Ballart J et al (2000) Comparison of the minimum fungicidal concentration of amphotericin B determined in filamentous fungi by macrodilution and microdilution methods. Med Mycol 38(1):23–26CrossRefPubMedGoogle Scholar
  56. Rahman A, Hossain MA, Kang SC (2010) Control of phytopathogenic fungi by the essential oil and methanolic extracts of Erigeron ramosus (Walt.) BSP. Eur J Plant Pathol 128(2):211–219CrossRefGoogle Scholar
  57. Rahman A, Al-Reza SM, Kang SC (2011) Antifungal activity of essential oil and extracts of Piper chaba Hunter against phytopathogenic fungi. J Am Oil Chem Soc 88(4):573–579CrossRefGoogle Scholar
  58. Rana IS, Rana AS, Rajak RC (2011) Evaluation of antifungal activity in essential oil of the Syzygium aromaticum (L.) by extraction, purification and analysis of its main component eugenol. Braz J Microbiol 42(4):1269–1277CrossRefPubMedPubMedCentralGoogle Scholar
  59. Randrianarivelo R, Sarter S, Odoux E, Brat P, Lebrun M, Romestand B et al (2009) Composition and antimicrobial activity of essential oils of Cinnamosma fragrans. Food Chem 114(2):680–684CrossRefGoogle Scholar
  60. Rao A, Zhang YQ, Muend S, Rao R (2010) Mechanism of antifungal activity of terpenoid phenols resembles calcium stress and inhibition of the TOR pathway. Antimicrob Agents Chemother 54(12):5062–5069CrossRefPubMedPubMedCentralGoogle Scholar
  61. Regnault-Roger C, Vincent C, Arnason JT (2012) Essential oils in insect control: low-risk products in a high-stakes world. Annu Rev Entomol 57:405–424CrossRefPubMedGoogle Scholar
  62. Reverchon E (1997) Supercritical fluid extraction and fractionation of essential oils and related products. J Supercrit Fluids 10:1–37CrossRefGoogle Scholar
  63. Ristic M, Sokovic M, Grubisic D et al (2004) Chemical analysis and antifungal activity of the essential oil of Achillea atrata L. J Essent Oil Res 16(1):75–78CrossRefGoogle Scholar
  64. Sampietro DA, Belizana MM, Baptista ZP, Vattuone MA, Catalán CA (2014) Essential oils from Schinus species of northwest Argentina: Composition and antifungal activity. Nat Prod Commun 9(7):1019–1022PubMedGoogle Scholar
  65. Scordino M, Sabatino L, Traulo P, Gagliano G, Gargano M, Panto V, Gambino GL (2008) LC/MS/MS detection of fungicide guazatine residues for duality assessment of commercial citrus fruit. Eur Food Res Technol 227(5):1339–1347CrossRefGoogle Scholar
  66. Shelef LA (1983) Antimicrobial effects of spices. J Food Saf 6:29–44Google Scholar
  67. Singh P, Kumar A, Dubey NK, Gupta R (2009) Essential oil of aegle marmelos as a safe plant-based antimicrobial against postharvest microbial infestations and aflatoxin contamination of food commodities. J Food Sci 74(6):M302–M307CrossRefPubMedGoogle Scholar
  68. Smith IM, Dunez J, Phillips DH, Lelliott RA, Archer SA (eds) (1988) European handbook of plant diseases. Blackwell Scientific Publications, Oxford, p 598Google Scholar
  69. Stenglein SA (2009) Fusarium poae: a pathogen that needs more attention. J Plant Pathol 91(1):25–36Google Scholar
  70. Summerell BA, Laurence MH, Liew ECY et al (2010) Biogeography and phylogeography of Fusarium: a review. Fungal Divers 44(1):3–13Google Scholar
  71. Turner NW, Subrahmanyam S, Piletsky SA (2009) Analytical methods for determination of mycotoxins: a review. Anal Chim Acta 632(2):168–180CrossRefPubMedGoogle Scholar
  72. Tyagi AK, Malik A (2011) Antimicrobial potential and chemical composition of Mentha piperita oil in liquid and vapour phase against food spoiling microorganisms. Food Control 22(11):1707–1714CrossRefGoogle Scholar
  73. Ultee A, Bennik MHJ, Moezelaar R (2002) The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus. Appl Environ Microbiol 68(4):1561–1568CrossRefPubMedPubMedCentralGoogle Scholar
  74. Villa-Ruano N, Pacheco-Hernández Y, Rubio-Rosas E, Lozoya-Gloria E, Mosso-González C, Ramón-Canul LG, Cruz-Durán R (2015a) Essential oil composition and biological/pharmacological properties of Salmea scandens (L.) DC. Food Control 57:177–184CrossRefGoogle Scholar
  75. Villa-Ruano N, Pacheco-Hernández Y, Cruz-Durán R, Lozoya-Gloria E (2015b) Volatiles and seasonal variation of the essential oil composition from the leaves of Clinopodium macrostemum var. laevigatum and its biological activities. Ind Crops Prod 77:741–747CrossRefGoogle Scholar
  76. Voon CH, Bhat R, Rusul G (2012) Flower extracts and their essential oils as potential antimicrobial agents for food uses and pharmaceutical applications. Compr Rev Food Sci Food Saf 11:34–55CrossRefGoogle Scholar
  77. Watanabe M, Yonezawa T, Lee K, Kumagai S, Sugita-Konishi Y, Goto K, Hara-Kudo Y (2011) Molecular phylogeny of the higher and lower taxonomy of the Fusarium genus and differences in the evolutionary histories of multiple genes. BMC Evol Biol 11:322CrossRefPubMedPubMedCentralGoogle Scholar
  78. White DG (1999) Compendium of corn diseases, 3rd edn. APS Press, p 78Google Scholar
  79. Wickern GM (1993) Fusarium allergic fungal sinusitis. J Allergy Clin Immunol 92:624CrossRefPubMedGoogle Scholar
  80. Xing F, Hua H, Selvaraj JN, Zhao Y, Zhou L, Liu X, Liu Y (2014) Growth inhibition and morphological alterations of Fusarium verticillioides by cinnamon oil and cinnamaldehyde. Food Control 46:343–350CrossRefGoogle Scholar
  81. Yamamoto-Ribeiro MMG, Grespan R, Kohiyama CY, Ferreira FD, Mossini SAG, Silva E et al (2013) Effect of Zingiber officinale essential oil on Fusarium verticillioides and fumonisin production. Food Chem 141(3):3147–3152CrossRefPubMedGoogle Scholar
  82. Yli-Mattila T (2011) Detection of trichothecene-producing Fusarium species in cereals in Northern Europe and Asia. Agron Res 9:521–526Google Scholar
  83. Yu CL, Kuang Y, Yang SX, Liu L, Liu CG (2014) Chemical composition, antifungal activity and toxicity of essential oils from leaves of Chimonanthus praecox and Chimonanthus zhejiangensis. Asian J Chem 26(1):254–256Google Scholar
  84. Zabka M, Pavela R (2013) Antifungal efficacy of some natural phenolic compounds against significant pathogenic and toxinogenic filamentous fungi. Chemosphere 93(6):1051–1056CrossRefPubMedGoogle Scholar
  85. Zabka M, Pavela R, Slezakova L (2009a) Antifungal effect of Pimenta dioica essential oil against dangerous pathogenic and toxinogenic fungi. Ind Crops Prod 30(2):250–253Google Scholar
  86. Zabka M, Pavela R, Slezakova L (2009b) Antifungal effect of Pimenta dioica essential oil against dangerous pathogenic and toxinogenic fungi. Ind Crop Prod 30(2):250–253CrossRefGoogle Scholar
  87. Zabka M, Pavela R, Prokinova E (2014) Antifungal activity and chemical composition of twenty essential oils against significant indoor and outdoor toxigenic and aeroallergenic fungi. Chemosphere 112:443–448CrossRefPubMedGoogle Scholar
  88. Zarn JA, Bruschweiler BJ, Schlatter JR (2003) Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase. Environ Health Perspect 111(3):255–261CrossRefPubMedPubMedCentralGoogle Scholar
  89. Zhang N, O’Donnell K, Sutton DA et al (2006) Members of the Fusarium solani species complex that cause infections in both humans and plantsare common in the environment. J Clin Microbiol 44(6):2186–2190Google Scholar

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Crop Research InstituteRuzyneCzech Republic

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