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Influence of Preterm Birth, BPD and Lung Inhomogeneity on Respiratory System Impedance – Model Studies

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Recent Developments and Achievements in Biocybernetics and Biomedical Engineering (PCBBE 2017)

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 647))

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Abstract

The influence of preterm birth, bronchopulmonary dysplasia (BPD) and lung inhomogeneity on respiratory system impedance (RSI) was studied. The simulation of spontaneous breathing in full term newborns (FT), very low birth weight (VLBW) and extremely low birth weight (ELBW) preterm infants was carried out using a developed linear RLC respiratory system model. Besides BPD, four types of lung inhomogeneity: (1) one-lung obstruction (OBSTR), (2) one-lung restriction (RESTR), (3) one-lung obstructive-restrictive disturbance (OBSTR-RESTR I), (4) bilateral obstructive-restrictive disturbance (OBSTR-RESTR II), with obstruction of one lung and restriction of the second, were studied.

The impact of preterm birth on infant RSI was stronger than the BPD impact. The differences in the real and imaginary parts of RSI, between full term, VLBW and ELBW infants, were much greater than between preterm infants with and without BPD. The shift of resonant frequency between full terms and ELBW amounted to 20 Hz, but between ELBW with and without BPD only 5 Hz.

The bilateral obstructive-restrictive lung inhomogeneity (OBSTR-RESTR II) with obstruction of one lung \(\left( R_{1}=10\cdot R_{2}\right) \) and restriction of the second lung \(\left( C_{2}=0.1\cdot C_{1}\right) \), appeared to have the most adverse influence on RSI. In ELBW with OBSTR-RESTR II, both the real and imaginary parts of RSI increased several times compared to healthy ELBW.

However, severe one-lung obstruction \(\left( R_{1}=10\cdot R_{2}\right) \) or one-lung restriction \(\left( C_{1}=0.1\cdot C_{2}\right) \) in preterm infants prompted significant increases of RSI compared to healthy infants. The 20% difference in airway resistance \(\left( R_{1}=1.2\cdot R_{2}\right) \) or lung compliance \(\left( C_{1}=1.2\cdot R_{2}\right) \) between the left and right lung seemed to be clinically unimportant.

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Authors and Affiliations

  1. Department of Modeling and Supporting of Internal Functions, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, ul. Ks. Trojdena 4, 02-109, Warszawa, Poland

    Barbara Stankiewicz, Marek Darowski & Krzysztof Jakub Pałko

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  1. Barbara Stankiewicz
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  2. Marek Darowski
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  3. Krzysztof Jakub Pałko
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Correspondence to Barbara Stankiewicz .

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Editors and Affiliations

  1. AGH University of Science and Technology, Krakow, Poland

    Piotr Augustyniak

  2. Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

    Roman Maniewski

  3. AGH University of Science and Technology, Krakow, Poland

    Ryszard Tadeusiewicz

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Stankiewicz, B., Darowski, M., Pałko, K.J. (2018). Influence of Preterm Birth, BPD and Lung Inhomogeneity on Respiratory System Impedance – Model Studies. In: Augustyniak, P., Maniewski, R., Tadeusiewicz, R. (eds) Recent Developments and Achievements in Biocybernetics and Biomedical Engineering. PCBBE 2017. Advances in Intelligent Systems and Computing, vol 647. Springer, Cham. https://doi.org/10.1007/978-3-319-66905-2_6

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  • DOI: https://doi.org/10.1007/978-3-319-66905-2_6

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