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Autonomous Microfluidic Capillary Network for on Chip Detection of Chemiluminescence

  • M. Nardecchia
  • D. Paglialunga
  • G. Petrucci
  • N. Lovecchio
  • F. Costantini
  • S. Pirrotta
  • G. de Cesare
  • D. Caputo
  • A. Nascetti
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 457)

Abstract

This work reports on the design, simulation and fabrication of an autonomous microfluidic network. It is a part of a highly integrated, new analytical platform for the multiparametric detection of bio-organic molecules in extra-terrestrial environment. The proposed microfluidic system, made in SU-8 3050, allows to obtain an autonomous microfluidic network able to have simultaneous capillary filling and fresh solution into each site of detection avoiding cross-contamination among different sites. Computational Fluid Dynamics (CFD) simulations have been carried in order to verify the proper operation of the designed microfluidic network and to optimize it. Technological processes have been refined and adapted in order to ensure good adhesion, using low-temperature and low-pressure bonding avoiding the risk of breaking the glass slides. Experiments have been conducted to verify the autonomous capillary filling of the entire network and its rinsing with buffer solution. The experimental results are in good agreement with the simulations.

Keywords

Lab-on-chip SU-8 3050 Microfluidic Capillary networks Bonding 

Notes

Acknowledgements

Authors would like to thank the Italian Space Agency through the project PLEIADES and the Italian Ministry of Education, University and Research (MIUR) through the University Research Project 2015 (prot. C26H15J3PX) for the financial supports.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • M. Nardecchia
    • 1
    • 2
  • D. Paglialunga
    • 1
  • G. Petrucci
    • 2
  • N. Lovecchio
    • 2
  • F. Costantini
    • 1
    • 3
  • S. Pirrotta
    • 4
  • G. de Cesare
    • 2
  • D. Caputo
    • 2
  • A. Nascetti
    • 1
  1. 1.School of Aerospace EngineeringSapienza University of RomeRomeItaly
  2. 2.D.I.E.T, Sapienza University of RomeRomeItaly
  3. 3.Department of ChemistrySapienza University of RomeRomeItaly
  4. 4.Italian Space AgencyRomeItaly

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