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Breath-Printing of Heart Failure in Elderly

  • A. Zompanti
  • P. Finamore
  • C. Pedone
  • M. Santonico
  • S. Grasso
  • F. R. Parente
  • G. Ferri
  • V. Stornelli
  • D. Lelli
  • L. Costanzo
  • R. Antonelli Incalzi
  • G. Pennazza
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 457)

Abstract

Comorbidity represents a confounding factor in exhaled breath analysis, in particular with elderly population, which often shows both respiratory and heart diseases. Congestive heart failure (CHF) is the first cause of hospitalization and a primary cause of death and disability in the elderly population. CHF has important metabolic implications, thus exhaled VOCs analysis may support CHF severity assessment and CHF discrimination against controls. VOCs pattern in CHF has not been yet investigated so far, even if an increase in acetone and pentane has been observed. Here, breathprint based CHF diagnosis and severity classification have been studied. Moreover, studying an elderly population, Chronic Obstructive Pulmonary Disease (COPD) patients have been enrolled, being COPD an important comorbidity in aged population.

Keywords

Breathprint Congestive heart failure (CHF) Elderly Gas sensor array Chronic obstructive pulmonary disease (COPD) 

References

  1. 1.
    Ziaeian, B., Fonarow, G.C.: Epidemiology and aetiology of heart failure. Nat. Rev. Cardiol. 13(6), 368–378 (2016)CrossRefGoogle Scholar
  2. 2.
    Samara, M.A., Wilson Tang, W.H., Cikach, F., Gul, Z., Tranchito, L., Paschke, K.M., et al.: Single exhaled breath metabolomic analysis identifies unique breathprint in patients with acute decompensated heart failure. J. Am. Coll. Cardiol. 61(13), 1463 (2013)CrossRefGoogle Scholar
  3. 3.
    Incalzi, R.A., Scarlata, S., Pennazza, G., Santonico, M., Pedone, C.: Chronic Obstructive Pulmonary Disease in the elderly. Eur. J. Intern. Med. 25, 320–328 (2014)CrossRefGoogle Scholar
  4. 4.
    Antonelli, Incalzi Raffaele, Pennazza, G., Simone, Scarlata, Marco, Santonico, Massimo, Petriaggi, Domenica, Chiurco, Claudio, Pedone, Arnaldo, D’Amico: Reproducibility and respiratory function correlates of exhaled breath fingerprint in chronic obstructive pulmonary disease. PLoS ONE 7, e45396 (2012)CrossRefGoogle Scholar
  5. 5.
    Samara, M.A., et al.: Single exhaled breath metabolomic analysis identifies unique breathprint in patients with acute decompensated heart failure. J. Am. Coll. Cardiol. 61(13), 1463 (2013)CrossRefGoogle Scholar
  6. 6.
    Pennazza, G., Santonico, M., Incalzi, R.A., Scarlata, S., Chiurco, D., Vernile, C., et al.: Measure chain for exhaled breath collection and analysis: a novel approach suitable for frail respiratory patients. Sens. Actuators B Chem. 1(204), 578–587 (2014)CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • A. Zompanti
    • 1
  • P. Finamore
    • 2
  • C. Pedone
    • 2
  • M. Santonico
    • 1
    • 3
  • S. Grasso
    • 1
  • F. R. Parente
    • 4
  • G. Ferri
    • 4
  • V. Stornelli
    • 4
  • D. Lelli
    • 2
  • L. Costanzo
    • 2
  • R. Antonelli Incalzi
    • 2
  • G. Pennazza
    • 1
  1. 1.Unit of Electronics for Sensor Systems, Department of EngineeringCampus Bio-Medico University of RomeRomeItaly
  2. 2.Chair of Geriatrics, Unit of Respiratory PathophysiologyCampus Bio-Medico UniversityRomeItaly
  3. 3.CNR-IDASCRomeItaly
  4. 4.Department of Industrial and Information Engineering and EconomicsUniversity of L’AquilaL’AquilaItaly

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