Skip to main content

Pathologic Myopia

  • Chapter
  • First Online:
Atlas of Ocular Optical Coherence Tomography
  • 2052 Accesses

Abstract

Pathologic or degenerative myopia is among the most frequent causes of blindness worldwide. Visual impairment is related and it is a bit more prevalent in Asian populations. There are multiple anatomical changes in the globe and ocular content with an increase in axial length and myopia, which recently have been better illustrated by OCT. In this chapter, we initially discuss the effects of ocular wall distortion on image quality and the interpretation of OCT images. Then, we elucidate the various ocular changes in myopia. This chapter divided into the following sections. (1) Effects of ocular distortion on OCT apparatus outputs and clinical features that subdivided into: (2) vascular microfolds; (3) tractional maculopathy, vitreoschisis, retinoschisis, and foveoschisis; (4) posterior macular detachment; (5) full-thickness macular holes; (6) peripapillary intrachoroidal cavitation; (7) paravascular lamellar holes, cysts, and other vascular abnormalities; (8) choroidal neovascularization; (9) the thin choroid with large scleral holes; (10) the dome-shaped macula; (11) the macular Bruch’s membrane defect; and (12) retinal nerve fiber layer changes and interpretation of thickness profiles in this group of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  1. Wong TY, Ferreira A, Hughes R, Carter G, Mitchell P. Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review. Am J Ophthalmol. 2014;157:9–25.e12.

    Article  PubMed  Google Scholar 

  2. Henaine-Berra A, Zand-Hadas IM, Fromow-Guerra J, García-Aguirre GP. Prevalence of macular anatomic abnormalities in high myopia. Ophthalmic Surg Lasers Imaging Retina. 2013;44:140–4.

    Article  PubMed  Google Scholar 

  3. You QS, Peng XY, Xu L, Chen CX, Wang YX, Jonas JB. Myopic maculopathy imaged by optical coherence tomography: the Beijing Eye Study. Ophthalmology. 2014;121:220–4.

    Article  PubMed  Google Scholar 

  4. Forte R, Cennamo G, Pascotto F, de Crecchio G. En face optical coherence tomography of the posterior pole in high myopia. Am J Ophthalmol. 2008;145:281–8.

    Article  PubMed  Google Scholar 

  5. Shimada N, Ohno-Matsui K, Nishimuta A, Moriyama M, Yoshida T, Tokoro T, et al. Detection of paravascular lamellar holes and other paravascular abnormalities by optical coherence tomography in eyes with high myopia. Ophthalmology. 2008;115:708–17.

    Article  PubMed  Google Scholar 

  6. Takano M, Kishi S. Foveal retinoschisis and retinal detachment in severely myopic eyes with posterior staphyloma. Am J Ophthalmol. 1999;128:472–6.

    Article  CAS  PubMed  Google Scholar 

  7. Cheng C, Teo K, Tan CS, Lee SY, Loh BK, Wong E, et al. Myopic retinoschisis in Asians: structural features and determinants of visual acuity and prognostic factors for progression. Retina. 2016;36:717–26.

    Article  PubMed  Google Scholar 

  8. Shimada N, Ohno-Matsui K, Nishimuta A, Tokoro T, Mochizuki M. Peripapillary changes detected by optical coherence tomography in eyes with high myopia. Ophthalmology. 2007;114:2070–6.

    Article  PubMed  Google Scholar 

  9. Shinohara K, Moriyama M, Shimada N, Yoshida T, Ohno-Matsui K. Characteristics of peripapillary staphylomas associated with high myopia determined by swept-source optical coherence tomography. Am J Ophthalmol. 2016;169:138–44.

    Article  PubMed  Google Scholar 

  10. Muraoka Y, Tsujikawa A, Hata M, Yamashiro K, Ellabban AA, Takahashi A, et al. Paravascular inner retinal defect associated with high myopia or epiretinal membrane. JAMA Ophthalmol. 2015;133:413–20.

    Article  PubMed  Google Scholar 

  11. Chan NS, Teo K, Cheung CM. Epidemiology and diagnosis of myopic choroidal neovascularization in Asia. Eye Contact Lens. 2016;42:48–55.

    Article  PubMed  Google Scholar 

  12. Leveziel N, Yu Y, Reynolds R, Tai A, Meng W, Caillaux V, et al. Genetic factors for choroidal neovascularization associated with high myopia. Invest Ophthalmol Vis Sci. 2012;53:5004–9.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ikuno Y, Jo Y, Hamasaki T, et al. Ocular risk factors for choroidal neovascularization in pathologic myopia. Invest Ophthalmol Vis Sci. 2010;51:3721–5.

    Article  PubMed  Google Scholar 

  14. Verteporfin in Photodynamic Therapy Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin. 1-year results of a randomized clinical trial—VIP Report no.1. Ophthalmology. 2001;108:841–5.

    Article  Google Scholar 

  15. Neelam K, Cheung CM, Ohno-Matsui K, Lai TY, Wong TY. Choroidal neovascularization in pathological myopia. Prog Retin Eye Res. 2012;31:495–525.

    Article  CAS  PubMed  Google Scholar 

  16. Wong TY, Ohno-Matsui K, Leveziel N, Holz FG, Lai TY, HG Y, et al. Myopic choroidal neovascularisation: current concepts and update on clinical management. Br J Ophthalmol. 2015;99:289–96.

    Article  PubMed  Google Scholar 

  17. Ikuno Y, Fujimoto S, Jo Y, Asai T, Nishida K. Choroidal thinning in high myopia measured by optical coherence tomography. Clin Ophthalmol. 2013;7:889.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2009;50:3876–80.

    Article  PubMed  Google Scholar 

  19. Fujiwara T, Imamura Y, Margolis R, Slakter JS, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol. 2009;148:445–50.

    Article  PubMed  Google Scholar 

  20. Flores-Moreno I, Lugo F, Duker JS, Ruiz-Moreno JM. The relationship between axial length and choroidal thickness in eyes with high myopia. Am J Ophthalmol. 2013;155:314–9.

    Article  PubMed  Google Scholar 

  21. Usui S, Ikuno Y, Miki A, Matsushita K, Yasuno Y, Nishida K. Evaluation of the choroidal thickness using high-penetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma. Am J Ophthalmol. 2012;153:10–6.

    Article  PubMed  Google Scholar 

  22. Ohsugi H, Ikuno Y, Oshima K, Yamauchi T, Tabuchi H. Morphologic characteristics of macular complications of a dome-shaped macula determined by swept-source optical coherence tomography. Am J Ophthalmol. 2014;158:162–70.e1.

    Article  PubMed  Google Scholar 

  23. You QS, Peng XY, Xu L, Chen CX, Wei WB, Wang Y, et al. Macular Bruchs membrane defects in highly myopic eyes: the Beijing Eye Study. Retina. 2016;36:517–23.

    Article  PubMed  Google Scholar 

  24. Ohno-Matsui K, Jonas JB, Spaide RF. Macular Bruch membrane holes in highly myopic patchy chorioretinal atrophy. Am J Ophthalmol. 2016;166:22–8.

    Article  PubMed  Google Scholar 

  25. Leung CK, Mohamed S, Leung KS. Retinal nerve fiber layer measurements in myopia: an optical coherence tomography study. Invest Ophthalmol Vis Sci. 2006;47:5171–6.

    Article  PubMed  Google Scholar 

  26. Choi YJ, Jeoung JW, Park KH, Kim DM. Glaucoma detection ability of ganglion cell-inner plexiform layer thickness by spectral-domain optical coherence tomography in high myopia. Invest Ophthalmol Vis Sci. 2013;54:2296–304.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fedra Hajizadeh M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Hajizadeh, F. (2018). Pathologic Myopia. In: Hajizadeh, F. (eds) Atlas of Ocular Optical Coherence Tomography. Springer, Cham. https://doi.org/10.1007/978-3-319-66757-7_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-66757-7_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-66756-0

  • Online ISBN: 978-3-319-66757-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics