Transcriptional and Genomic Advances on the Pathophysiology of Stem Cell Repairment After Intracerebral Hemorrhage

  • Sheng Zhang
  • Yongjie Zhou
  • Yujie ChenEmail author
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Intracerebral hemorrhage is a life-threatening disease characterized by a sudden rupture of cerebral blood vessels, and it is widely believed that neural cell death occurs after exposure to blood metabolites or subsequently damaged cells. Based on these disappointing results of 1026 neuroprotective agents, researchers turned their interests on neurogenesis, which is traditionally considered as an endogenous neuroprotective mechanism after acute central nervous system injuries. However, because of complexity in stem cell survival, migration, differentiation, and maturation, current strategies have either been proved unsatisfactory or resulted in serious side effects during clinical translation. It is well known that transcriptional and genomic pathways play important roles in ensuring the normal functions of stem cells, including proliferation, migration, differentiation and neural reconnection. And reprogramming technology and other non-invasive electromagnetic stimulation were recently employed and proved effective for the stem cell characteristics. Therefore, in the present chapter, we sought to summarize the advances in the pathophysiology and strategies of stem cell repairment after ICH at the level of transcription and genome, hoping to provide potential sparks for better stem cell repairment for ICH patients.


Stem cell Intracerebral hemorrhage Transcriptome Genome Bioinformatics Reprogramming technology Neurological recovery 



Intracerebral hemorrhage


Long non-coding RNA




Neural stem cell


super-paramagnetic iron oxide


Surgical Trial in Intracerebral Hemorrhage


subependymal ventricular zone


United States Food and Drug Administration



This work was supported by Incubation Foundation of Interdisciplinary Laboratory of Physics and Biomedicine (Grant No. WSS-2015-08), Basic Science and Advanced Technology Research Project of Chongqing (Grant No. cstc2016jcyjA1730), National Natural Science Foundation of China (Grant No. 81501002, 81220108009) and National Basic Research Program of China (973 Program, Grant No. 2014CB541600).

Conflicts of Interest: The authors declared no potential conflicts of interest.


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Neurosurgery, Southwest HospitalThird Military Medical UniversityChongqingChina
  2. 2.Department of NeurosurgeryThe 184th Hospital of People’s Liberation ArmyYingtan, CityChina

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