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Transcriptional and Genomic Advances on the Pathophysiology of Stem Cell Repairment After Intracerebral Hemorrhage

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Cellular and Molecular Approaches to Regeneration and Repair

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Intracerebral hemorrhage is a life-threatening disease characterized by a sudden rupture of cerebral blood vessels, and it is widely believed that neural cell death occurs after exposure to blood metabolites or subsequently damaged cells. Based on these disappointing results of 1026 neuroprotective agents, researchers turned their interests on neurogenesis, which is traditionally considered as an endogenous neuroprotective mechanism after acute central nervous system injuries. However, because of complexity in stem cell survival, migration, differentiation, and maturation, current strategies have either been proved unsatisfactory or resulted in serious side effects during clinical translation. It is well known that transcriptional and genomic pathways play important roles in ensuring the normal functions of stem cells, including proliferation, migration, differentiation and neural reconnection. And reprogramming technology and other non-invasive electromagnetic stimulation were recently employed and proved effective for the stem cell characteristics. Therefore, in the present chapter, we sought to summarize the advances in the pathophysiology and strategies of stem cell repairment after ICH at the level of transcription and genome, hoping to provide potential sparks for better stem cell repairment for ICH patients.

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Abbreviations

ICH:

Intracerebral hemorrhage

LncRNA:

Long non-coding RNA

miRNA:

MicroRNA

NSC:

Neural stem cell

SPIO:

super-paramagnetic iron oxide

STICH:

Surgical Trial in Intracerebral Hemorrhage

SVZ:

subependymal ventricular zone

US FDA:

United States Food and Drug Administration

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Acknowledgements

This work was supported by Incubation Foundation of Interdisciplinary Laboratory of Physics and Biomedicine (Grant No. WSS-2015-08), Basic Science and Advanced Technology Research Project of Chongqing (Grant No. cstc2016jcyjA1730), National Natural Science Foundation of China (Grant No. 81501002, 81220108009) and National Basic Research Program of China (973 Program, Grant No. 2014CB541600).

Conflicts of Interest: The authors declared no potential conflicts of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Street, Shapingba District, Chongqing, 400038, China

    Sheng Zhang & Yujie Chen M.D., Ph.D.

  2. Department of Neurosurgery, The 184th Hospital of People’s Liberation Army, Yingtan, City, Jiangxi Province, China

    Yongjie Zhou

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  1. Sheng Zhang
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  3. Yujie Chen M.D., Ph.D.
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Correspondence to Yujie Chen M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, AHSP, Los Angeles, California, USA

    Paul A. Lapchak

  2. Department of Physiology, Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Zhang, S., Zhou, Y., Chen, Y. (2018). Transcriptional and Genomic Advances on the Pathophysiology of Stem Cell Repairment After Intracerebral Hemorrhage. In: Lapchak, P., Zhang, J. (eds) Cellular and Molecular Approaches to Regeneration and Repair. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-66679-2_6

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  • DOI: https://doi.org/10.1007/978-3-319-66679-2_6

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