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The Role of Matricellular Proteins in Experimental Subarachnoid Hemorrhage-Induced Early Brain Injury

  • Lei Liu
  • Hidenori SuzukiEmail author
Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Abstract

Subarachnoid hemorrhage (SAH) is a serious life-threatening type of stroke caused by bleeding into the subarachnoid space surrounding the brain. It elicits a wide range of stress responses in brain tissues and results in brain injury. The term early brain injury (EBI) is a concept to explain pathophysiological changes that occur in brain within 72 h of SAH. Matricellular proteins (MCPs) are a class of nonstructural extracellular matrix proteins that exert diverse functions through binding to cell surface receptors, growth factors, cytokines and other MCPs. Until now, some of MCPs have been investigated in clinical SAH settings and laboratory studies. Here, we review the role of MCPs in post-SAH EBI by focusing on osteopontin, tenascin-C, and periostin.

Keywords

Subarachnoid hemorrhage Early brain injury Matricellular proteins Osteopontin Tenascin-C Periostin 

Abbreviations

Ang

Angiopoietin

BBB

Blood-brain barrier

CCN

Cyr61/CTGF/NOV

CICES

Complement inhibiting component of Ephedra sinica

CSF

Cerebrospinal fluid

EBI

Early brain injury

ECM

Extracellular matrix

EGFR

Epidermal growth factor receptor

ERK

Extracellular signal-regulated kinase

FAK

Focal adhesion kinase

IL

Interleukin

ILK

Integrin-linked kinase

JNK

c-Jun N-terminal kinase

MAPK

Mitogen-activated protein kinase

MCP

Matricellular protein

MKP

Mitogen-activated protein kinase phosphatase

MMP

Matrix metalloproteinase

NF

Nuclear factor

OPN

Osteopontin

PDGFR

Platelet-derived growth factor receptor

P-gp

P-Glycoprotein

PI3K

Phosphatidylinositol 3-kinase

RGD

l-Arginyl-glycyl-l-aspartate

r-OPN

Recombinant osteopontin

SAH

Subarachnoid hemorrhage

siRNA

Short-interfering ribonucleic acid

SMA

Smooth muscle actin

SMemb

Embryonic smooth muscle myosin heavy chain

TLR

Toll-like receptor

TNC

Tenascin-C

TNKO

Tenascin-C knockout

VEGF

Vascular endothelial growth factor

VEGFR

Vascular endothelial growth factor receptor

VSMC

Vascular smooth muscle cell

ZO

Zona occludens

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryMie University Graduate School of MedicineTsuJapan
  2. 2.Research Center for Matrix BiologyMie University Graduate School of MedicineTsuJapan

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