SB623 Preclinical and Clinical Trial Experience

  • Eric S. SussmanEmail author
  • Gary K. Steinberg
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Stroke affects more than 15 million individuals each year, and is the second leading cause of mortality worldwide [1]. In the United States alone, there are nearly 800,000 strokes annually, and over seven million individuals (approximately 3% of the adult population) live with the sequelae of a prior stroke [2]. More than half of these individuals suffer from long-term limitation of functional mobility [3]. From an economic perspective, the direct and indirect costs related to stroke are as high as $65 billion per year in the United States [4].


Stroke Neuroregeneration Cell-based therapy Stem cells Mesenchymal stem cells SB623 cells 



Adverse event


Brain-derived neurotrophic factor


Basic fibroblast growth factor


Diffusion-weighted imaging


Extracellular matrix


Epidermal growth factor


Embryonic stem cells


European Stroke Scale


Food and Drug Administration


Fugl-Meyer Assessment


Glial cell line-derived neurotrophic factor


Insulin-like growth factor 1


Magnetic resonance imaging


Modified Rankin Scale


Mesenchymal stem cells


National Institute of Health Stroke Scale


Neural stem cells


Randomized controlled trial MCA, middle cerebral artery


T2-weighted-fluid-attenuated inversion recovery


Treatment emergent adverse event


Vascular endothelial growth factor



We thank Christine Plant for assistance with the manuscript.

Funding: This work was supported in part by funding from Bernard and Ronni Lacroute, the William Randolph Hearst Foundation and Marc Paskin.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Neurosurgery and Stanford Stroke CenterStanford University School of Medicine and Stanford Health Care, Stanford UniversityStanfordUSA

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