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Understanding the Gut-Bone Signaling Axis pp 59–94Cite as

Immunology of Gut-Bone Signaling

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1033))

Abstract

In recent years a link between the gastrointestinal tract and bone health has started to gain significant attention. Dysbiosis of the intestinal microbiota has been linked to the pathology of a number of diseases which are associated with bone loss. In addition modulation of the intestinal microbiota with probiotic bacteria has revealed to have both beneficial local and systemic effects. In the present chapter, we discuss the intestinal and bone immune systems, explore how intestinal disease affects the immune system, and examine how these pathologic changes could adversely impact bone health.

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Author notes

  1. Laura R McCabe and Narayanan Parameswaran contributed equally to this work and are co-senior authors.

Authors and Affiliations

  1. Department of Physiology, Michigan State University, East Lansing, MI, USA

    Fraser L. Collins, Jonathan D. Schepper, Naiomy Deliz Rios-Arce, Michael D. Steury, Ho Jun Kang, Heather Mallin, Daniel Schoenherr, Glen Camfield, Saima Chishti & Narayanan Parameswaran

  2. Comparative Medicine and Integrative Biology Program, East Lansing, MI, USA

    Naiomy Deliz Rios-Arce & Narayanan Parameswaran

  3. Department of Physiology and Department of Radiology, Biomedical Imaging Research Centre, Michigan State University, East Lansing, MI, USA

    Laura R. McCabe

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  1. Fraser L. Collins
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  11. Narayanan Parameswaran
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Corresponding authors

Correspondence to Laura R. McCabe or Narayanan Parameswaran .

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Editors and Affiliations

  1. Department of Physiology and Department of Radiology Biomedical Imaging Research Centre, Michigan State University, East Lansing, Michigan, USA

    Laura R. McCabe

  2. Comparative Medicine and Integrative Biology Program, East Lansing, Michigan, USA

    Narayanan Parameswaran

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Collins, F.L. et al. (2017). Immunology of Gut-Bone Signaling. In: McCabe, L., Parameswaran, N. (eds) Understanding the Gut-Bone Signaling Axis. Advances in Experimental Medicine and Biology, vol 1033. Springer, Cham. https://doi.org/10.1007/978-3-319-66653-2_5

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