Abstract
Endophytic fungi are ubiquitous in internal tissues of healthy plants and are known to biosynthesis a remarkable array of secondary metabolites with diverse chemical structures and assist host plants to overcome both abiotic and biotic stress factors in their natural environment. Screening technologies have established these natural products are an outstanding source of biologically active metabolites with promising medicinal and agricultural applications. Selection of plants from distinct environmental settings and/or with unconventional biology is expected to enhance the chances of isolating novel fungal endophytes as well as new bioactive secondary metabolites. Using selected examples from different ecological niches, this review illustrates the chemical potential of endophytic fungi for producing pharmaceutically and agriculturally valuable products. The biosynthesis of the same specific biologically active metabolites by the endopyte as well as the host plant and the factors that influence the production of secondary metabolites by the endophyte are also discussed. Finally, the current challenges in the production and commercialization of bioactive compounds of endophytic fungal origin are debated.
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Ratnaweera, P.B., de Silva, E.D. (2017). Endophytic Fungi: A Remarkable Source of Biologically Active Secondary Metabolites. In: Maheshwari, D., Annapurna, K. (eds) Endophytes: Crop Productivity and Protection. Sustainable Development and Biodiversity, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-319-66544-3_9
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