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Application of LIPUS for Bone Healing

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Abstract

Therapeutic low-intensity pulsed ultrasound (LIPUS) has been used to enhance bone healing caused by fracture in human and animal models, and it has been well accepted in accelerating tibial fracture healing, by delivering mechanical stimulation by means of LIPUS at an intensity of 30 mW/cm2, with 200-ms pulses generated at a frequency of 1.5 MHz. For not only normal bone fracture but also for complex bone fractures in the presence of metabolic bone diseases such as diabetes mellitus (DM) and osteoporosis (OP), LIPUS might promote bone healing with increased mechanical strength and callus size together with reduced healing times. This implies that LIPUS can be a promising therapeutic tool for accelerating the fracture healing process. However, there has been still a controversy about the effects of LIPUS in human trials. Therefore, well-designed and precise clinical studies are needed to operate for further applications in tissue engineering.

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Author information

Authors and Affiliations

  1. Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

    Karima Mansjur & Eiji Tanaka

  2. Department of Orthodontics, King Abdulaziz University, Jeddah, Saudi Arabia

    Eiji Tanaka

Authors
  1. Karima Mansjur
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  2. Eiji Tanaka
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Correspondence to Eiji Tanaka .

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Editors and Affiliations

  1. Dentistry/Orthodontics and Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada

    Tarek El-Bialy

  2. Department of Orthodontics and Dentofacial Orthopedics Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

    Eiji Tanaka

  3. Technion—Faculty of Medicine Oral Biology Research Laboratory, Rambam Health Care Campus, Haifa, Israel

    Dror Aizenbud

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Mansjur, K., Tanaka, E. (2018). Application of LIPUS for Bone Healing. In: El-Bialy, T., Tanaka, E., Aizenbud, D. (eds) Therapeutic Ultrasound in Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-319-66323-4_3

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  • DOI: https://doi.org/10.1007/978-3-319-66323-4_3

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-66323-4

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