Abstract
Ionizing radiation induces a severe form of DNA damage through clustering of ionizations: the DNA double-strand break (DSB).
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
References
Durante, M., & Cucinotta, F. A. (2008). Heavy ion carcinogenesis and human space exploration. Nature Reviews Cancer, 8(6), 465–472.
Fuks, Z., & R. R. Weichselbaum (1995). Radiation therapy. In J. Mendelsohn, P. M. Howley, M. A. Israel and L. A. Liotta (Eds.), The Molecular Basis of Cancer (pp. 401–431). Philadelphia, London, Toronto, Montreal, Sydney, Tokyo: W.B. Saunders Company.
Ginsburg, G. S., Angrist, M., & Cook-Deegan, R. (2006). Genomics and Medicine at a Crossroads in Chernobyl. Science, 314, 62–63.
Goodhead, D. T. (1989). The initial physical damage produced by ionizing radiations. International Journal of Radiation Biology, 56(5), 623–634.
Goodhead, D. T. (1994). Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. International Journal of Radiation Biology, 65(1), 7–17.
Hall, E. J., & Giaccia, A. J. (2006). Radiobiology for the Radiologist. Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sydney, Tokyo: Lippincott Williams & Wilkins.
Hendry, J. H. (2012). Radiation biology and radiation protection. Annals of the ICRP, 41(3–4), 64–71.
Iliakis, G., Murmann, T., & Soni, A. (2015). Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 793, 166–175.
Mladenov, E., Magin, S., Soni, A., & Iliakis, G. (2016). DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation. Seminars in Cancer Biology, 37–38, 51–64.
Peplow, M. (2011). Chernobyl’s legacy. Nature, 471, 562–565.
Schipler, A., & Iliakis, G. (2013). DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Research, 41(16), 7589–7605.
Ward, J. F. (1994). The Complexity of DNA damage: Relevance to biological consequences. International Journal of Radiation Biology, 66(5), 427–432.
Wondergem, J., Boerma, M., Kodama, K., Stewart, F., & Trott, K. (2013). Cardiovascular effects after low-dose exposure and radiotherapy: what research is needed? Radiation and Environmental Biophysics, 52(4), 425–434.
Acknowledgements
This work was supported in part by the DFG graduate training program (GRK1431) and grants from BMBF and BMWi.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this chapter
Cite this chapter
Iliakis, G. (2018). The Biological Foundations of Risks from Ionizing Radiation Exposures: How an Understanding of Associated Effects Will Help Their Quantification and Mitigation. In: Wilderer, P., Renn, O., Grambow, M., Molls, M., Mainzer, K. (eds) Sustainable Risk Management. Strategies for Sustainability. Springer, Cham. https://doi.org/10.1007/978-3-319-66233-6_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-66233-6_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-66232-9
Online ISBN: 978-3-319-66233-6
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)