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Platelets as Regulators of Thrombosis and Inflammation

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Platelets, Haemostasis and Inflammation

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 5))

Abstract

This chapter describes features of blood platelets that serve in the regulation of thrombosis and inflammation. Classically, platelets have been known for decades to promote hemostasis of wounds and arterial thrombosis, in particular atherothrombosis following atherosclerotic plaque rupture. More recently, the importance of platelets for the development of deep vein thrombosis has been recognized. But platelets also link thrombosis and inflammation in “immunothrombosis” within microvessels. In a collaborative “effort” of several cell types, plasma proteins, and neutrophil extracellular traps, platelets orchestrate the recognition, trapping, and killing of pathogens. Immunothrombosis also occurs in microvessels during ischemia–reperfusion injury, e.g., following myocardial infarction. In acute and chronic inflammation, platelets further cooperate with neutrophils, monocytes, and lymphocytes without clot formation to promote physiological—and pathophysiological—responses to pathogens or auto-antigens.

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Authors and Affiliations

  1. Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany

    Daniel Duerschmied MD

  2. Internal Medicine III – Intensive Care Medicine, University Hospital of Freiburg, Freiburg, Germany

    Daniel Duerschmied MD

  3. Medizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-Universität, Munich, Germany

    Steffen Massberg

  4. DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany

    Steffen Massberg

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  1. Cardiology and Angiology I, University-Heart Center Freiburg, Freiburg, Germany

    Andreas Zirlik

  2. Cardiology and Angiology I, University-Heart Center Freiburg, Freiburg, Germany

    Christoph Bode

  3. Department of Cardiology, University Hospital Tübingen, Tübingen, Germany

    Meinrad Gawaz

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Duerschmied, D., Massberg, S. (2017). Platelets as Regulators of Thrombosis and Inflammation. In: Zirlik, A., Bode, C., Gawaz, M. (eds) Platelets, Haemostasis and Inflammation. Cardiac and Vascular Biology, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-66224-4_4

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