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Platelets and HMGB1 in Sterile and Non-sterile Inflammation

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Platelets, Haemostasis and Inflammation

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 5))

Abstract

Platelets play a critical role in hemostasis, thrombosis, wound healing, and inflammation. We have recently shown that the damage-associated molecular pattern molecule (DAMP) high-mobility group box 1 (HMGB1) derived from platelets plays a critical role in mediating thrombosis and inflammation. The specific role of platelet-derived HMGB1 in various platelet-relevant disease states and events and the underlying pathophysiological triggers are still poorly understood. Here, we give an overview of HMGB1 and platelets in the context of sterile and non-sterile inflammation, with a focus on ischemia/reperfusion injury and dengue virus infection.

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Authors and Affiliations

  1. University Hospital Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Germany

    Sebastian Vogel & Meinrad Gawaz

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  1. Sebastian Vogel
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  2. Meinrad Gawaz
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Correspondence to Meinrad Gawaz .

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Editors and Affiliations

  1. Cardiology and Angiology I, University-Heart Center Freiburg, Freiburg, Germany

    Andreas Zirlik

  2. Cardiology and Angiology I, University-Heart Center Freiburg, Freiburg, Germany

    Christoph Bode

  3. Department of Cardiology, University Hospital Tübingen, Tübingen, Germany

    Meinrad Gawaz

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  • Conflict of Interest: Sebastian Vogel and Meinrad Gawaz declares that they have no conflict of interest.

  • Ethical Approval: This article does not contain any studies with human participants or animals performed by any of the authors.

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Vogel, S., Gawaz, M. (2017). Platelets and HMGB1 in Sterile and Non-sterile Inflammation. In: Zirlik, A., Bode, C., Gawaz, M. (eds) Platelets, Haemostasis and Inflammation. Cardiac and Vascular Biology, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-66224-4_14

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