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Malignancy-Associated Genodermatoses

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Skin Tumors and Reactions to Cancer Therapy in Children

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Abstract

Genodermatoses, while rare, are an important and unique aspect of pediatric dermatology. In this chapter, we will introduce genodermatoses that are associated with malignancies and review how they typically present. We will emphasize genodermatoses with onset of cutaneous malignancy in childhood (younger than 21 years of age) and provide a summary of those correlated with internal malignancy. The chapter is divided into four main sections: genodermatoses associated with (1) primary cutaneous malignancies (BCC, SCC, and melanoma), (2) photosensitivity-induced cutaneous malignancies, (3) other causes of secondary cutaneous malignancies, and (4) extracutaneous malignancies. For each main genodermatosis, we will discuss brief background of disease pathogenesis (if known), characteristic skin findings, associated malignancies, and basic management strategies. Awareness and recognition of malignancy-associated genodermatoses are critical for correct and timely diagnosis, as well as implementation of appropriate screening for patients.

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Recommended Reading

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Author notes

  1. Sarah N. Robinson and Hannah Song contributed equally to this work.

Authors and Affiliations

  1. Department of Dermatology, Harvard Combined Dermatology Residency Program, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA

    Sarah N. Robinson M.D.

  2. Department of Dermatology, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA

    Hannah Song B.A.

  3. Division of Immunology, Dermatology Program, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA

    Jennifer T. Huang M.D.

Authors
  1. Sarah N. Robinson M.D.
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  2. Hannah Song B.A.
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  3. Jennifer T. Huang M.D.
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Correspondence to Jennifer T. Huang M.D. .

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Editors and Affiliations

  1. Harvard Medical School, Boston Children’s Hospital, Boston, Massachusetts, USA

    Jennifer T. Huang

  2. Washington University School of Medicine, St. Louis, Missouri, USA

    Carrie C. Coughlin

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Robinson, S.N., Song, H., Huang, J.T. (2018). Malignancy-Associated Genodermatoses. In: Huang, J., Coughlin, C. (eds) Skin Tumors and Reactions to Cancer Therapy in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-66200-8_5

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