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Skin Cancer and Other Late Effects of Cancer Therapy

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Skin Tumors and Reactions to Cancer Therapy in Children

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Abstract

Though skin cancer is uncommon in children, patients with a history of cancer therapy, solid organ or hematopoietic stem cell transplantation, and genetic predisposition syndromes are at increased risk. Basal cell and squamous cell carcinoma, as well as posttransplant lymphoproliferative disorder and Kaposi’s sarcoma, are covered in this chapter. When not associated with a genetic syndrome, these skin cancers can occur as side effects of cancer therapy or secondary to immunosuppression. Permanent alopecia is a very visible, challenging long-term effect of surgical, medical, and radiation therapy for cancer. Scars can be similarly distressing to cancer survivors. Autoimmune disorders, such as vitiligo and alopecia areata can occur after cancer therapy, as well. Given the importance and impact of these sequelae of therapy, care and screening recommendations and references to aid in clinical management and prevention are discussed at the end of the chapter.

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Recommended Reading

  • Chow EJ, Anderson L, Baker KS, Bhatia S, Guilcher GM, Huang JT, et al. Late effects surveillance recommendations among survivors of childhood hematopoietic cell transplantation: a Children’s Oncology Group report. Biol Blood Marrow Transplant. 2016;22(5):782–95.

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  • Zuo RC, Naik HB, Steinberg SM, Baird K, Mitchell SA, Kuzmina Z, et al. Risk factors and characterization of vitiligo and alopecia areata in patients with chronic graft-vs-host disease. JAMA Dermatol. 2015;151(1):23–32.

    Article  PubMed  Google Scholar 

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Acknowledgements

Thank you to Elizabeth Nieman, M.D., who helped outline this chapter.

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  1. Division of Dermatology, Departments of Medicine and Pediatrics, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Carrie C. Coughlin M.D.

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  1. Carrie C. Coughlin M.D.
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Correspondence to Carrie C. Coughlin M.D. .

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Editors and Affiliations

  1. Harvard Medical School, Boston Children’s Hospital, Boston, Massachusetts, USA

    Jennifer T. Huang

  2. Washington University School of Medicine, St. Louis, Missouri, USA

    Carrie C. Coughlin

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Coughlin, C.C. (2018). Skin Cancer and Other Late Effects of Cancer Therapy. In: Huang, J., Coughlin, C. (eds) Skin Tumors and Reactions to Cancer Therapy in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-66200-8_11

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