Abstract
During the chlortetracycline (CTC) fermentation process, if the fermenter is invaded by other harmful bacteria, the fermentation broth may be contaminated. Once this occurs, the broth must be discharged for preventing other schedules of fermentation production from contamination, otherwise it will waste more raw materials and bring great economical damage. In order to acquire some important comprehensive contamination feature information, an information fusion method is proposed in this paper based on Desert-Smarandache theory (DSmT), combining multiple process information that indirectly hints contamination. And experimental results based on field data show that the method can predict whether the process of CTC fermentation is contaminated, so if this method is applied into real fermentation production, the safety performance of production process will be improved.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Li, Y.Q., He, X.R.: Study on breeding chlortetracycline streptomyces by microwave mutagenesis and laser mutagenesis. Chin. J. Biotechnol. 14(4), 445–448 (1998)
Fu, J.L.: Optimization and metabolic validation of chlortetracycline fermentation process based on parameter. East China Univ. Sci. Technol. (2003)
Pang, G.F., Cao, Y.Z., Zhang, J.J., et al.: Simultaneous determination of oxytetracycline, tetracycline, chlortetracycline and doxycycline in poultry meat by high performance liquid chromatography. J. Instrum. Anal. 24(4), 61–63 (2005)
Wang, H.Z., Luo, Y., Xu, W.Q., et al.: Ecotoxic effects of tetracycline and chlortetracycline on aquatic organisms. J. Agro Environ. Sci. 27(4), 1536–1539 (2008)
Liu, J.G., Zhao, Z.H., Zhang, B.K., et al.: Effects of a Chinese herb feed additive and chlortetracycline on the growth of growing piglets and their mechanism. J. Southwest Agric. Univ. 27(6), 877–880 (2006)
Li, W., Yan, Z.: Determination of oxytetracycline, tetracycline and chlortetracycline residue in animal meat. Chin. J. Health Lab. Technol. 11(6), 730–731 (2001)
Olsson, L., Nielson, J.: On-line and in situ monitoring of biomass in submerged cultivations. Trends Biotechnol. 15(12), 517–522 (1997)
Wang, Y.J., Fan, Y.: Studies of on-line and in-situ measuring method for biomass concentration. Prog. Biochem. Biophys. 27(4), 387–390 (2000)
Wang, B., Sun, Y.K., Huang, Y.H., et al.: Soft sensor method for lysine fermentation process based on adaptive FLSVM. Chin. J. Sci. Instrum. 32(2), 469–474 (2011)
Wang, J.L., Feng, X.Y., Yu, T., et al.: Research progress of optimal control techniques in fermentation process. Chem. Ind. Eng. Prog. 27(8), 1210–1214 (2008)
Camu, N., González, A., De Winter, T., et al.: Influence of turning and environmental contamination on the dynamics of populations of lactic acid and acetic acid bacteria involved in spontaneous cocoa bean heap fermentation in Ghana. Appl. Environ. Microbiol. 74(1), 86–98 (2008)
Lv, D.M., Cai, L.P., Shi, W., et al.: Study on the problem of bacterial contamination. Coal Chem. Ind. 3(2), 86–87 (2013)
Junker, B., Lester, M., Leporati, J., et al.: Sustainable reduction of bioreactor contamination in an industrial fermentation pilot plant. J. Biosci. Bioeng. 102(4), 251–268 (2006)
Acknowledgments
The research work was supported by Pucheng Zhengda Fujian Biochemical Co. Ltd. We also thank Charoen Pokphand Group for providing the industrial datasets offed-batch CTC fermentation process.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this paper
Cite this paper
Tang, Lt. et al. (2018). Study of Prediction Methods for Contamination in the Chlortetracycline Fermentation Process. In: Qiao, F., Patnaik, S., Wang, J. (eds) Recent Developments in Mechatronics and Intelligent Robotics. ICMIR 2017. Advances in Intelligent Systems and Computing, vol 690. Springer, Cham. https://doi.org/10.1007/978-3-319-65978-7_14
Download citation
DOI: https://doi.org/10.1007/978-3-319-65978-7_14
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-65977-0
Online ISBN: 978-3-319-65978-7
eBook Packages: EngineeringEngineering (R0)