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Collagenase in Dupuytren Disease pp 39–74Cite as

Collagenase in Europe from the Experimental Phase to Practical Use

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Abstract

The use of enzymatic fasciotomy with clostridium histolyticum collagenase for the management of Dupuytren’s contracture has progressively increased since its approval for clinical use. The main reason for that is the fact that it is a non-invasive, safe, effective and quick procedure.

A systematic search was performed combining the following keywords: ‘Dupuytren disease’ and ‘collagenase’ and ‘clostridium histolyticum’. One hundred fifty-nine studies published by European authors were selected. Many papers were rejected for not reporting the results of the treatment.

Treatment with clostridium histolyticum collagenase provides good results in Dupuytren’s contracture, especially in the metacarpal phalangeal joints. In addition to that, it is cost-effective.

The advantages of the procedure are the short recovery period and the low incidence of severe adverse effects. The patients’ satisfaction level is generally high.

The majority of studies do not use subjective valuation systems; they have short follow-up periods and do not follow the consensus criteria to define recurrences. However, their results are usually similar to those of the clinical trials.

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Notes

  1. 1.

    JFV: Dr. Joaquín Forés Vilalta.

  2. 2.

    ALG: Dra. Anna López Gutiérrez.

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Disclosure Statement

We declare that co-authors JMAR and RSC have received honoraria and travel expenses for advisory board work with Pfizer and Sobi. The authors have no conflicts of interest relevant to this work.

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Authors and Affiliations

  1. Unidad del Miembro Superior, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain

    José M. Arandes-Renú & Ignacio Moya-Molinas

  2. Cirugía Ortopédica y Traumatología, Hospital de Denia, Alicante, Spain

    Rafael Sanjuán-Cerveró

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  1. José M. Arandes-Renú
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Correspondence to José M. Arandes-Renú .

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  1. Hand Surgery & Rehabilitation Department-Ospedale San Giuseppe, MultiMedica Group, Milan, Italy

    Giorgio Pajardi

  2. Stony Brook University Medical Center, New York, USA

    Marie A. Badalamente

  3. Department of Orthopaedics, Stony Brook University Medical Center, New York, USA

    Lawrence C. Hurst

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Arandes-Renú, J.M., Sanjuán-Cerveró, R., Moya-Molinas, I. (2018). Collagenase in Europe from the Experimental Phase to Practical Use. In: Pajardi, G., Badalamente, M., Hurst, L. (eds) Collagenase in Dupuytren Disease . Springer, Cham. https://doi.org/10.1007/978-3-319-65822-3_4

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