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Normative Ranges of Transcranial Doppler Metrics

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Intracranial Pressure & Neuromonitoring XVI

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 126))

Abstract

Objective: To determine normal ranges for traditional transcranial Doppler (TCD) measurements for two age groups (14–19 and 20–29 years) and compare to existing literature results. The development of a normal range for TCD measurements will be required for the development of diagnostic and prognostic tests in the future.

Materials and Methods: We performed TCD on the middle cerebral artery on 147 healthy subjects aged 18.9 years (SD = 2.1) and calculated mean cerebral blood flow velocity (mCBFV) and pulsatility index (PI). The study population was divided into two age populations (14–19 and 20–29 years).

Results: There was a significant decrease in PI (p = 0.015) for the older age group with no difference in mCBFV.

Conclusion: Age-related, normal data are a prerequisite for TCD to continue to gain clinical acceptance. Our correlation of age-related TCD findings with previously published results as the generally accepted “gold standard” underlines the validity and sensitivity of this ultrasound method.

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Acknowledgments

This work was supported partially by the National Institutes of Health Small Business Innovation Research (NINDS 1R43NS092209-01) and private funds from Neural Analytics Inc.

Conflicts of interest statement

Solventa Krakauskaite – No Conflict of interest, Corey Thibeault – Employee and shareholder of Neural Analytics, James LaVangie – Employee and shareholder of Neural Analytics, Mateo Scheidt – Employee and shareholder of Neural Analytics, Leo Martinez – Employee and shareholder of Neural Analytics, Danielle Seth-Hunter – Employee and shareholder of Neural Analytics, Amanda Wu – Employee and shareholder of Neural Analytics, Michael O’Brien – Employee and shareholder of Neural Analytics, Fabien Scalzo – Contractor and shareholder of Neural Analytics, Seth J.Wilk – Employee and shareholder of Neural Analytics, Robert B. Hamilton – Employee and shareholder of Neural Analytics.

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Authors and Affiliations

  1. Kaunas University of Technology, Kaunas, Lithuania

    Solventa Krakauskaite

  2. Neural Analytics, Los Angeles, CA, USA

    Corey Thibeault, James LaVangie, Mateo Scheidt, Leo Martinez, Danielle Seth-Hunter, Amanda Wu, Michael O’Brien, Seth J. Wilk & Robert B. Hamilton

  3. UCLA, Los Angeles, CA, USA

    Fabien Scalzo

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  1. Solventa Krakauskaite
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Corresponding author

Correspondence to Robert B. Hamilton .

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Editors and Affiliations

  1. Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Thomas Heldt

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Krakauskaite, S. et al. (2018). Normative Ranges of Transcranial Doppler Metrics. In: Heldt, T. (eds) Intracranial Pressure & Neuromonitoring XVI. Acta Neurochirurgica Supplement, vol 126. Springer, Cham. https://doi.org/10.1007/978-3-319-65798-1_53

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  • DOI: https://doi.org/10.1007/978-3-319-65798-1_53

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-65797-4

  • Online ISBN: 978-3-319-65798-1

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