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In Vivo Reprogramming Towards Pluripotency for Tissue Repair and Regeneration

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In Vivo Reprogramming in Regenerative Medicine

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

The generation of pluripotent-like, proliferative cells within an injured, aged or degenerated tissue via direct in vivo reprogramming (OSKM overexpression) has been proposed as a new therapeutic avenue to tackle conditions in which the regenerative capabilities of the organism cannot cope with the magnitude of cell loss. Thanks to their capacity to proliferate and to re-differentiate into mature phenotypes, in vivo reprogrammed cells could act as an in situ source of replacement cells, avoiding the challenges associated to ex vivo cell therapy. In this Chapter, we discuss this and other opportunities offered by the in vivo overexpression of reprogramming factors (OSKM) and analyse the challenges ahead of clinical translation of this strategy. Encouraging, yet scarce, studies that confirm enhanced regeneration following in vivo OSKM overexpression in different models of tissue injury are also discussed, with special focus on induction schemes specifically designed to avoid tumorigenesis.

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Authors and Affiliations

  1. Nanomedicine Lab, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

    Irene de Lázaro & Kostas Kostarelos

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  1. Irene de Lázaro
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  2. Kostas Kostarelos
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Correspondence to Irene de Lázaro or Kostas Kostarelos .

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  1. Biomedical Engineering Department, Ankara University, Tandogan, Ankara, Turkey

    Açelya Yilmazer

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de Lázaro, I., Kostarelos, K. (2017). In Vivo Reprogramming Towards Pluripotency for Tissue Repair and Regeneration. In: Yilmazer, A. (eds) In Vivo Reprogramming in Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-65720-2_6

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