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Nail Unit Psoriasis

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Scher and Daniel’s Nails

Abstract

Prevalence of nail psoriasis ranges from 7% to 56%, in psoriatic patients and significantly burdens quality of life. Nail psoriasis is associated with psoriatic arthritis and may be secondary to inflammation of the enthesis around the distal interphalangeal joint. Clinical features present due to inflammation of either the nail matrix or the nail bed and include pitting, leukonychia, red spots in the lunula, crumbling, onycholysis, splinter hemorrhages, subungual hyperkeratosis, and oil-drop salmon patches. Management of nail psoriasis should be individualized, and this depends on the number of nails affected, involvement of skin and/or joints, and co morbidities that might affect the choice of topical or systemic therapies.

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References

  1. de Berker DAR, Baran R, Dawber RPR. The nail in dermatological diseases. In: Baran R, Dawber RPR, de Berker DAR, Haneke E, Tosti A, editors. Baran and Dawber’s diseases of the nails and their management. 3rd ed. Malden: Blackwell Science; 2001. p. 172–222.

    Chapter  Google Scholar 

  2. Richert B, Caucanas M. Epidemiology of nail psoriasis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis From A to Z. Switzerland: Springer International Publishing; 2014. p. 1–11.

    Google Scholar 

  3. McGonagle D. Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease. J Eur Acad Dermatol Venereol. 2009;23(Suppl 1):9–13.

    Article  CAS  PubMed  Google Scholar 

  4. Radtke MA, Langenbruch AK, Schäfer I, Herberger K, Reich K, Augustin M. Nail psoriasis as a severity indicator: results from the PsoReal study. Patient Relat Outcome Meas. 2011;2:1–6.

    PubMed  Google Scholar 

  5. Augustin M, Reich K, Blome C, et al. Nail psoriasis in Germany: epidemiology and burden of disease. Br J Dermatol. 2010;163:580–5.

    Article  CAS  PubMed  Google Scholar 

  6. Ortonne JP, Baran R, Corvest M, et al. Development and validation of nail psoriasis quality of life scale (NPQ10). J Eur Acad Dermatol Venereol. 2010;24:22–7.

    Article  CAS  PubMed  Google Scholar 

  7. Belyayeva E, Gregoriou S, Chalikias J, Kontochristopoulos G, Koumantaki E, Makris M, Koti I, Katoulis A, Katsambas A, Rigopoulos D. The impact of nail disorders on quality of life. Eur J Dermatol. 2013;23(3):366–71.

    Article  PubMed  Google Scholar 

  8. Rich P, Griffiths CE, Reich K, Nestle FO, Scher RK, Li S, Xu S, Hsu MC, Guzzo C, et al. Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. J Am Acad Dermatol. 2008;58(2):224–31.

    Article  PubMed  Google Scholar 

  9. Baran R, Tosti A. Nails. In: Fitzpatrick TB, Freedberg IM, editors. Fitzpatrick’s dermatology in general medicine, vol. I. 6th ed. New York: McGraw-Hill, Medical Pub. Division; 2003.

    Google Scholar 

  10. van der Velden HM, Klaassen KM, van de Kerkhof PC, Pasch MC. Fingernail psoriasis reconsidered: a case-control study. J Am Acad Dermatol. 2013;69(2):245–52.

    Article  PubMed  Google Scholar 

  11. Palmou N, Marzo-Ortega H, Ash Z, Goodfield M, Coates LC, Helliwell PS, McGonagle D. Linear pitting and splinter haemorrhages are more commonly seen in the nails of patients with established psoriasis in comparison to psoriatic arthritis. Dermatology. 2011;223(4):370–3.

    Article  PubMed  Google Scholar 

  12. Puri N, Mahajan BB. Nail changes in psoriasis – a profile. J Pak Assoc Dermatol. 2011;21(3):165–9.

    Google Scholar 

  13. Brazzelli V, Carugno A, Alborghetti A, Grasso V, Cananzi R, Fornara L, De Silvestri A, Borroni G. Prevalence, severity and clinical features of psoriasis in fingernails and toenails in adult patients: Italian experience. J Eur Acad Dermatol Venereol. 2012;26(11):1354–9.

    Article  CAS  PubMed  Google Scholar 

  14. Salomon J, Szepietowski JC, Proniewicz A. Psoriatic nails: a prospective clinical study. J Cutan Med Surg. 2003;7(4):317–21.

    Article  PubMed  Google Scholar 

  15. Edwards F, de Berker D. Nail psoriasis: clinical presentation and best practice recommendations. Drugs. 2009;69(17):2351–61.

    Article  CAS  PubMed  Google Scholar 

  16. Jadhav VM, Mahajan PM, Mhaske CB. Nail pitting and onycholysis. Indian J Dermatol Venereol Leprol. 2009;75(6):631–3.

    Article  PubMed  Google Scholar 

  17. Singh SK. Fingernail pitting in psoriasis and its relation with different variables. Indian J Dermatol. 2013;58(4):310–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Holzberg M. Common nail disorders. Dermatol Clin. 2006;24(3):349–54.

    Article  CAS  PubMed  Google Scholar 

  19. Baran RL. A nail psoriasis severity index. Br J Dermatol. 2004;150:568–9.

    Article  CAS  PubMed  Google Scholar 

  20. Baran R, Dawber RPR. Baran and Dawber’s diseases of the nails and their management. 3rd ed. Malden: Blackwell Science; 2001.

    Book  Google Scholar 

  21. Wilkerson MG, Wilkin JK. Red lunulae revisited: a clinical and histopathologic examination. J Am Acad Dermatol. 1989;20(3):453–7.

    Article  CAS  PubMed  Google Scholar 

  22. de Berker D. Erythronychia. Dermatol Ther. 2012;25(6):603–11.

    Article  PubMed  Google Scholar 

  23. Lesher JL Jr, Peterson CM, Lane JE. An unusual case of factitious onychodystrophy. Pediatr Dermatol. 2004;21(3):239–41.

    Article  PubMed  Google Scholar 

  24. Jiaravuthisan MM, Sasseville D, Vender RB, Murphy F, Muhn CY. Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy. J Am Acad Dermatol. 2007;57(1):1–27.

    Article  PubMed  Google Scholar 

  25. Baran R, Dawber RPR, Haneke E, Tosti A, Bristow I. A text atlas of nails disorders: techniques in investigation and diagnosis. 3rd ed. London: Martin Dunitz; 2003.

    Book  Google Scholar 

  26. Zaias N. Psoriasis of the nail: a clinical-pathologic study. Arch Dermatol. 1969;99(5):567–79.

    Article  CAS  PubMed  Google Scholar 

  27. Daniel CR 3rd, Iorizzo M, Piraccini BM, Tosti A. Grading simple chronic paronychia and onycholysis. Int J Dermatol. 2006;45(12):1447–8.

    Article  PubMed  Google Scholar 

  28. Tosti A, Piraccini B. Chapter 89: Biology of nails and nails disorders. In: Wolff K, editor. Fitzpatrick’s dermatology in general medicine. New York: McGraw-Hill; 2012.

    Google Scholar 

  29. Jackson RH. Splinter haemorrhages in the fingernails. Br Med J. 1963;2(5371):1485–6.

    PubMed  Google Scholar 

  30. Bloom R, Tosti A. The clinical features of nail psoriasis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 44–55.

    Google Scholar 

  31. Tosti A, Piraccini B. Dermatological diseases that affect the nail. In: Hordinsky MK, Sawaya M, Scher RK, editors. Atlas of hair and nails. Philadelphia: Saunders; 2000. p. xii. 252 p.

    Google Scholar 

  32. Kouskoukis CE, Scher RK, Ackerman AB. The “oil drop” sign of psoriatic nails. Am J Dermatopathol. 1983;5(3):259–62.

    Article  CAS  PubMed  Google Scholar 

  33. Zaiac MN, Weiss E. Mohs micrographic surgery of the nail unit and squamous cell carcinoma. Dermatol Surg. 2001;27(3):246–51.

    CAS  PubMed  Google Scholar 

  34. Zaias N. The nail in health and disease. 2nd ed. Norwalk: Appleton & Lange; 1990.

    Google Scholar 

  35. Tham SN, Lim JJ, Tay SH, Chiew YF, Chua TN, Tan E, Tan T. Clinical observations on nail changes in psoriasis. Ann Acad Med Singap. 1988;17:482–5.

    CAS  PubMed  Google Scholar 

  36. Dogra A, Arora AK. Nail psoriasis: the journey so far. Indian J Dermatol. 2014;59(4):319–33.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Piraccini BM, Bruni F, Starace M. Dermoscopy of non-skin cancer nail disorders. Dermatol Ther. 2012;25(6):594–602.

    Article  PubMed  Google Scholar 

  38. Gewirtzman AJ, Saurat JH, Braun RP. An evaluation of dermoscopy fluids and application techniques. Br J Dermatol. 2003;149(1):59–63.

    Article  CAS  PubMed  Google Scholar 

  39. Tosti APB, Farias DC. Nail dermoscopy. In: Micali G, editor. Videodermatoscopy in clinical practice. London: Informa Healthcare; 2009.

    Google Scholar 

  40. Farias DC, Tosti A, Chiacchio ND, Hirata SH. Dermoscopy in nail psoriasis. An Bras Dermatol. 2010;85(1):101–3.

    Article  PubMed  Google Scholar 

  41. Patel S, Tosti A. Dermoscopy of nail psoriasis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis. From A to Z. Switzerland: Springer International publishing; 2014. p. 65–71.

    Chapter  Google Scholar 

  42. Iorizzo M, Dahdah M, Vincenzi C, Tosti A. Videodermoscopy of the hyponychium in nail bed psoriasis. J Am Acad Dermatol. 2008;58(4):714–5.

    Article  PubMed  Google Scholar 

  43. Ohtsuka T, Yamakage A, Miyachi Y. Statistical definition of nail fold capillary pattern in patients with psoriasis. Int J Dermatol. 1994;33(11):779–82.

    Article  CAS  PubMed  Google Scholar 

  44. Zaric D, Clemmensen OJ, Worm AM, Stahl D. Capillary microscopy of the nail fold in patients with psoriasis and psoriatic arthritis. Dermatologica. 1982;164(1):10–4.

    Article  CAS  PubMed  Google Scholar 

  45. Bhushan M, Moore T, Herrick AL, Griffiths CE. Nail fold video capillaroscopy in psoriasis. Br J Dermatol. 2000;142(6):1171–6.

    Article  CAS  PubMed  Google Scholar 

  46. Lencastre A, Lamas A, Sá D, Tosti A. Onychoscopy. Clin Dermatol. 2013;31(5):587–93.

    Article  PubMed  Google Scholar 

  47. Micali G, Lacarrubba F. Possible applications of videodermatoscopy beyond pigmented lesions. Int J Dermatol. 2003;42:430–3.

    Article  PubMed  Google Scholar 

  48. Wortsman X, Soto R. Ultrasound imaging of psoriatic nails. In: Rigopoulos D, Tosti A, editors. Nail psoriasis. From A to Z. Switzerland: Springer International publishing; 2014. p. 58–63.

    Chapter  Google Scholar 

  49. Gisondi P, Idolazzi L, Girolomoni G. Ultrasonography reveals nail thickening in patients with chronic placque psoriasis. Arch Dermatol Res. 2012;304(9):727–32.

    Article  CAS  PubMed  Google Scholar 

  50. Aydin SZ, Castillo-Gallego C, Ash ZR, Abignano G, Marzo-Ortega H, Wittmann M, Del Galdo F, McGonagle D. Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. Dermatology. 2013;227(1):45–51.

    Article  PubMed  Google Scholar 

  51. Aydin SZ, Ash Z, Del Galdo F, Marzo-Ortega H, Wakefield RJ, Emery P, McGonagle D. Optical coherence tomography: a new tool to assess nail disease in psoriasis? Dermatology. 2011;222(4):311–3.

    Article  PubMed  Google Scholar 

  52. Ribeiro CF, Holler AP, Skake TL. Periungual capillascopy in psoriasis. Ana Bras Dermatol. 2012;87(4):550–3.

    Article  Google Scholar 

  53. Zaric D, Clemmerson Q, Worm A, Stahl D. Capillary microscopy of the nail fold in patients with psoriasis and psoriatic arthritis. Dermatologica. 1982;164:10–4.

    Article  CAS  PubMed  Google Scholar 

  54. Salli L, Raimondi F, Pappalardo A. Periungual capillaroscopy in psoriatic arthritis. Clin Ter. 1999;150:409–12.

    CAS  PubMed  Google Scholar 

  55. Tan ES, Chong WS, Tey HL. Nail psoriasis: a review. Am J Clin Dermatol. 2012;13:375–88.

    Article  PubMed  Google Scholar 

  56. Jadhav VM, Mahajan PM, Mhaske CB. Nail pitting and onycholysis. Indian J Dermatol Venereol. 2009;75:631–3.l.

    Article  Google Scholar 

  57. Tosti A, Piraccani B. Dermatologic diseases. In: Scher RK, editor. Nails diagnosis, therapy and surgery. 3rd ed. Philadelphia: Saunders; 2005. p. 116.

    Google Scholar 

  58. Yin N, Tosti A. Differential diagnosis for nail psoriasis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 86–95.

    Google Scholar 

  59. Yung A, Johnson P, Goodfield MJ. Isotretinoin-induced elkonyxis. Br J Dermatol. 2005;153:671–2.

    Article  CAS  PubMed  Google Scholar 

  60. Greene RA, Scher RK. Nail changes associated with diabetes mellitus. J Am Acad Dermatol. 1987;16:1015–21.

    Article  CAS  PubMed  Google Scholar 

  61. Baran R, Dawber RPR, Haneke E, Tosti A. Nail plate and soft tissue abnormalities. In: Baran R, Dawber RPR, Haneke E, Tosti A, Bristow I, Thomas L, et al., editors. A text atlas of nail disorders – techniques in investigation and diagnosis. London: Taylor & Francis; 2003.

    Chapter  Google Scholar 

  62. Tosti A, Piraccani BM. Nail disorders. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. Cambridge: Mosby Elsevier; 2012. cap. 70. p. 1019–36.

    Google Scholar 

  63. Tosti A, Daniel R, Piraccani B, Iorizzo M. Color atlas of nails. 1st ed. Berlin: Springer; 2009.

    Google Scholar 

  64. Daniel CR 3rd, Iorizzo M, Piraccini BM, Tosti A. Simple onycholysis. Cutis. 2011;87:226–8.

    PubMed  Google Scholar 

  65. Dawber RP, Samman PD, Bottoms E. Fingernail growth in idiopathic and psoriatic onycholysis. Br J Dermatol. 1971;85:558–60.

    Article  CAS  PubMed  Google Scholar 

  66. Natarajan V, Nath AK, Thappa DM, Singh R, Verma SK. Coexistence of onychomycosis in psoriatic nails: a descriptive study. Indian J Dermatol Venereol Leprol. 2010;76:723.

    PubMed  Google Scholar 

  67. Sigurgeirsson B, Steingrimsson O. Risk factors associated with onychomycosis. J Eur Acad Dermatol Venereol. 2004;18:48–51.

    Article  CAS  PubMed  Google Scholar 

  68. Kacar N, Ergin S, Ergin C, Erdogan BS, Kaleli I. The prevalence, aetiological agents and therapy of onychomycosis in patients with psoriasis: a prospective controlled trial. Clin Exp Dermatol. 2007;32:1–5.

    CAS  PubMed  Google Scholar 

  69. Gupta AK, Lynde CW, Jain HC, Sibbald RG, Elewski BE, Daniel CR 3rd, Watteel GN, Summerbell RC. A higher prevalence of onychomycosis in psoriatics compared with non-psoriatics: a multicentre study. Br J Dermatol. 1997;136:786–9.

    Article  CAS  PubMed  Google Scholar 

  70. Klaassen KM, Dulak MG, van de Kerkhof PC, Pasch MC. The prevalence of onychomycosis in psoriatic patients: a systematic review. J Eur Acad Dermatol Venereol. 2014;28(5):533–41.

    Article  CAS  PubMed  Google Scholar 

  71. Larsen GK, Haedersdal M, Svejgaard EL. The prevalence of onychomycosis in patients with psoriasis and other skin diseases. Acta Derm Venereol. 2003;83(3):206–9.

    Article  PubMed  Google Scholar 

  72. Dorschner RA, Lopez-Garcia B, Massie J, Kim C, Gallo RL. Innate immune defense of the nail unit by antimicrobial peptides. J Am Acad Dermatol. 2004;50(3):343–8.

    Article  PubMed  Google Scholar 

  73. Minisini AM, Tosti A, Sobrero AF, Mansutti M, Piraccini BM, Sacco C, et al. Taxane-induced nail changes: incidence, clinical presentation and outcome. Ann Oncol. 2003;14:333–7.

    Article  CAS  PubMed  Google Scholar 

  74. Gregoriou S, Karagiorga T, Stratigos A, Volonakis K, Kontochristopoulos G, Rigopoulos D. Photo-onycholysis caused by olanzapine and aripiprazole. J Clin Psychopharmacol. 2008;28:219–20.

    Article  PubMed  Google Scholar 

  75. Baran R, Juhlin L. Photoonycholysis. Photodermatol Photoimmunol Photomed. 2002;18:202–7.

    Article  PubMed  Google Scholar 

  76. Baran R, Juhlin L. Drug-induced photo-onycholysis. Three subtypes identified in a study of 15 cases. J Am Acad Dermatol. 1987;17:1012–6.

    Article  CAS  PubMed  Google Scholar 

  77. Gregoriou S, Argyriou G, Larios G, Rigopoulos D. Nail disorders and systemic disease: what the nails tell us. J Fam Pract. 2008;57:509–14.

    PubMed  Google Scholar 

  78. Gregoriou S, Papafragkaki D, Rigopoulos D. Nails. In: Hall JC, Hall BJ, editors. Hall’s manual of skin as a marker of underlying disease: Shelton Connecticut USA: People’s medical publishing house; 2011. p. 207–26.

    Google Scholar 

  79. Scher RK, Daniel R. Nails: therapy, diagnosis, and surgery. Philadelphia: W.B. Sanders Company; 1990.

    Google Scholar 

  80. Blum M, Aviram A. Splinter hemorrhages in patients receiving regular hemodialysis. JAMA. 1978;239:47.

    Article  CAS  PubMed  Google Scholar 

  81. Kelly MP, Kight MA, Castillo S. Trophic implications of altered body composition observed in or near the nails of hemodialysis patients. Adv Ren Replace Ther. 1998;M5:241–51.

    Article  Google Scholar 

  82. Sanders CV, Saenz RE, Lopez M. Splinter hemorrhages and onycholysis: unusual reactions associated with tetracycline hydrochloride therapy. South Med J. 1976;69:1090–2.

    Article  CAS  PubMed  Google Scholar 

  83. Mortimer PS, Dawber RP. Trauma to the nail unit including occupational sports injuries. Dermatol Clin. 1985;3:415–20.

    Article  CAS  PubMed  Google Scholar 

  84. Saladi RN, Persaud AN, Rudikoff D, Cohen SR. Idiopathic splinter hemorrhages. J Am Acad Dermatol. 2004;50:289–92.

    Article  PubMed  Google Scholar 

  85. Kouskoukis CE, Scher RK, Ackerman AB. The “oil drop” sign of psoriatic nails. A clinical finding specific for psoriasis. Am J Dermatopathol. 1983;5:259–62.

    Article  CAS  PubMed  Google Scholar 

  86. Haneke E. Nail psoriasis. In: Soung J, Koo B, editors. Psoriasis. Rijeka: Intech; 2011. 978-953-307-878.

    Google Scholar 

  87. Haneke E. Pathology. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 15–21.

    Chapter  Google Scholar 

  88. Piraccini BM, Fanti PA, Morelli R, Tosti A. Hallopeau’s acrodermatitis continua of the nail: a clinical and pathological study of 20 patients. Acta Derm Venereol. 1994;74(1):65–7.

    CAS  PubMed  Google Scholar 

  89. Rigopoulos D, Prevezas C. Severity evaluation indexes. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 1–11.

    Chapter  Google Scholar 

  90. Pierard GE, Pierard-Franchmimont C. Dynamics of psoriatic trachyonychia during low-dose cyclosporine-A treatment: a pilot study on onychochronobiology using optical profilometry. Dermatology. 1996;192:116–9.

    Article  CAS  PubMed  Google Scholar 

  91. Rich P, Scher R. Nail psoriasis severity-index: a useful tool for evaluation of nail psoriasis. J Am Acad Dermatol. 2003;49:206–12.

    Article  PubMed  Google Scholar 

  92. Rigopoulos D, Gregoriou S, Makris M, et al. Efficacy of Ustekinumab in nail psoriasis and improvement in nail-associated quality of life in a population treated with Ustekinumab for cutaneous psoriasis: an open prospective unblinded study. Dermatology. 2011;223(4):325–9.

    Article  CAS  PubMed  Google Scholar 

  93. Tosti A, Ricotti C, Romanelli P, et al. Evaluation of the efficacy of Acitretin therapy for nail psoriasis. Arch Dermatol. 2009;145(3):269–71.

    Article  CAS  PubMed  Google Scholar 

  94. Bianchi L, Bergamin A, de Felice C, et al. Remission and time of resolution of nail psoriasis during infliximab therapy. J Am Acad Dermatol. 2005;52(4):736–7.

    Article  PubMed  Google Scholar 

  95. Bardazzi F, Antonucci VA, Tengattini V, et al. A 36-week retrospective open trial comparing the efficacy of biological therapies in nail psoriasis. J Dtsch Dermatol Ges. 2013;11(11):1065–70.

    PubMed  Google Scholar 

  96. Cassell SE, et al. The modified nail psoriasis severity index: validation of an instrument to assess psoriatic nail involvement in patients with psoriatic arthritis. J Rheumatol. 2007;34:123–9.

    PubMed  Google Scholar 

  97. Aktan S, Ilknur T, Akin C, et al. Inter-observer reliability of the nail psoriasis severity index. Clin Exp Dermatol. 2007;32:141–4.

    Article  CAS  PubMed  Google Scholar 

  98. Parrish CA, Sobera JO, Elewski BO. Modification of nail psoriasis severity index. J Am Acad Dermatol. 2005;53(4):745–6. author reply 746–7

    Article  PubMed  Google Scholar 

  99. Augustin M, Blome C, Costanzo A, et al. Nail Assessment in Psoriasis and Psoriatic Arthritis (NAPPA): development and validation of a tool for assessment of nail psoriasis outcomes. Br J Dermatol. 2014;170(3):591–8.

    Article  CAS  PubMed  Google Scholar 

  100. Oran Y, Akkaya D. Treatment of nail psoriasis: common concepts and new trends. Dermatol Res Pract. 2013;23:1–13.

    Article  Google Scholar 

  101. Gregoriou S, Kalogeromitros D, Kosionis N, et al. Treatment options for nail psoriasis. Exp Rev Dermatol. 2008;3(3):339–44.

    Article  Google Scholar 

  102. Radtke A, Beikert F, Augustin M. Nail psoriasis-a treatment challenge. J Dtsch Dermatol Ges. 2013;103:203–19.

    Google Scholar 

  103. Reich K. Approach to managing patients with nail psoriasis. J Eur Acad Dermatol Venereol. 2009;23(Suppl 1):15–21.

    Article  PubMed  Google Scholar 

  104. Jaravuthisan M, Sasseville D, Vender R, et al. Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy. J Am Acad Dermatol. 2007;57:1–27.

    Article  Google Scholar 

  105. Dehesa L, Tosti A. Treatment of inflammatory nail disorders. Dermatol Ther. 2012;25:525–34.

    Article  PubMed  Google Scholar 

  106. Cannavo SP, Guarneri F, Vaccaro M, et al. Treatment of psoriatic nails with topical cyclosporine: a prospective randomized, placebo-controlled study. Dermatology. 2003;206:153–6.

    Article  CAS  PubMed  Google Scholar 

  107. De Berker D, Lawrence CM. A simplified protocol of steroid injection for psoriatic nail dystrophy. Br J Dermatol. 1998;138:90–5.

    Article  PubMed  Google Scholar 

  108. De Berker D. Management of psoriatic nail disease. Semin Cutan Med Surg. 2009;28:39–43.

    Article  PubMed  CAS  Google Scholar 

  109. Saleem K, Azim W. Treatment of nail psoriasis with a modified regimen of steroid injections. J Coll Physicians Surg Pak. 2008;18(2):78–81.

    PubMed  Google Scholar 

  110. De Berker D. Management of nail psoriasis. Clin Exp Dermatol. 2000;25:357–62.

    Article  PubMed  Google Scholar 

  111. Scher RK, Daniel CR. Nails: therapy, diagnosis, surgery. Philadelphia: W.B. Saunders Company; 2003.

    Google Scholar 

  112. Baran R, Tosti A. Treatment of nail psoriasis with a new corticoid – containing nail lacquer formulation. J Dermatol Treat. 1999;10:201–4.

    Article  CAS  Google Scholar 

  113. Sanchez Regana M, Martin Ezwuerra G, Millet U, et al. Treatment of nail psoriasis with 8% clobetasol nail lacquer: positive experience in 10 patients. J Eur Acad Dermatol Venereol. 2005;19:573–7.

    Article  CAS  PubMed  Google Scholar 

  114. Nakamura R, Duque-Estrada B, Pizzaro Leverone A, et al. Comparison of nail lacquer clobetasol efficacy at 0, 05%, 1% and 8% in nail psoriasis treatment: prospective, controlled and randomized pilot study. An Bras Dermatol. 2012;87(2):203–11.

    Article  PubMed  Google Scholar 

  115. van Le Q, Howard A. Dexamethasone iontophoresis for the treatment of nail psoriasis. Aust J Dermatol. 2013;54:115–9. Tosti A, Piraccini BM, Cameli N, et al. Calcipotriol ointment in nail psoriasis: a controlled, double-blind comparison with betamethasone dipropionate and salicylic acid. Br J Dermatol. 1998;139:655–9.

    Article  Google Scholar 

  116. Tosti A, Piraccini BM, Cameli N, et al. Calcipotriol ointment in nail psoriasis: a controlled, double-blind comparison with betamethasone dipropionate and salicylic acid. Br J Dermatol. 1998;139:655–9.

    Article  CAS  PubMed  Google Scholar 

  117. Zakeri M, Valikhani M, Mortazavi H, et al. Topical calcipotriol therapy in nail psoriasis: a study of 24 cases. Dermatol Online J. 2005;11(3):5–9.

    Article  PubMed  Google Scholar 

  118. Rigopoulos D, Ioannides D, Prastitis N, et al. Nail psoriasis: a combined treatment using calcipotriol cream and clobetasol propionate cream. Acta Dermatol Venereol. 2002;82(2):140–3.

    Article  CAS  Google Scholar 

  119. Piraccini BM, Tosti A, Iorizzo M, et al. Pustular psoriasis of the nails: treatment and long-term follow-up of 46 patients. Br J Dermatol. 2001;144:1000–5.

    Article  CAS  PubMed  Google Scholar 

  120. Balbas-Marquez M, Sanchez-Regana M, Millet-Umbert P. Tacalcitol ointment for the treatment of nail psoriasis. J Dermatol Treat. 2009;20(5):308–10.

    Article  CAS  Google Scholar 

  121. Kole L, Cantrell W, Elewski B. A randomized, double-blinded trial evaluating the efficacy and tolerability of vectical ointment (calcitriol 3 mcg/g ointment) when compared to betamethasone diproprionate ointment (64 mg/g) in patients with nail psoriasis. J Drugs Dermatol. 2014;13(8):912–5.

    CAS  PubMed  Google Scholar 

  122. Scher RK, Stiller M, Zhu YI. Tazarotene 0.1% gel in the treatment of fingernail psoriasis: a double-blind, randomized, vehicle-controlled study. Cutis. 2001;68:355–8.

    CAS  PubMed  Google Scholar 

  123. Bianchi L, Soda R, Diluvio L, et al. Tazarotene 0.1% gel for psoriasis of the fingernails and toenails: an open, prospective study. Br J Dermatol. 2003;149(1):207–9.

    Article  CAS  PubMed  Google Scholar 

  124. Rigopoulos D, Gregoriou S, Katsambas A. Treatment of psoriatic nails with Tazarotene 0.1% gel vs clobetasol propionate 0.05% cream: a double-blind study. Acta Derm Venereol. 2007;87(2):167–8.

    Article  CAS  PubMed  Google Scholar 

  125. Levancini-Fischer C, Sanchez-Regana M, Lambi F, et al. Nail psoriasis: treatment with tazarotene 0.1% hydrophilic ointment. Actas Dermosifiliogr. 2012;103(8):725–8.

    Article  Google Scholar 

  126. Fritz K. Successful local treatment of nail psoriasis with 5-fluorouracil. Z Hautarz. 1989;15(64):1083–8.

    Google Scholar 

  127. de Jong EM, Menke HE, van Praag MC, et al. Dystrophic psoriatic fingernails treated with 1% fluorouracil in a nail-penetration-enhancing vehicle. Dermatology. 1999;199:313–8.

    Article  PubMed  Google Scholar 

  128. Yamamoto T, Katayana I, Nishioka K. Topical anthralin therapy for refractory nail psoriasis. J Dermatol. 1998;25(4):231–3.

    Article  CAS  PubMed  Google Scholar 

  129. De Simone C, Maiorino A, Tassone F, et al. Tacrolimus 0,1% ointment in nail psoriasis: a randomized, controlled, open-label study. J Eur Acad Dermatol Venereol. 2013;27:1003–6.

    Article  PubMed  CAS  Google Scholar 

  130. Hoffmann C, Plewig G. Photochemotherapie der nagelpsoriasis. Hautarzt. 1977;28:498–9.

    Google Scholar 

  131. Handfield-Jones SE, Boyle J, Harman RRM. Local PUVA treatment for nail psoriasis. Br J Dermatol. 1987;116(2):280–1.

    Article  CAS  PubMed  Google Scholar 

  132. Stern DK, Creasey AA, Quigigie J, et al. UVA and UVB penetration of normal human cadaveric fingernail plate. Arch Dermatol. 2011;147(4):439–41.

    Article  PubMed  Google Scholar 

  133. Trieewittayapoon C, Sigvahamont P, Chanprapaph K, et al. The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: a randomized, doubleblind, intrapatient left-to-right study. J Am Acad Dermatol. 2012;66:807–12.

    Article  Google Scholar 

  134. Oram Y, Karincaoğlu Y, Koyuncu E, et al. Pulsed dye laser in the treatment of nail psoriasis. Dermatol Surg. 2010;36(3):377–81.

    Article  CAS  PubMed  Google Scholar 

  135. Al-Mutairi N, Noor T, Al-Haddad. Single blinded left-to-right comparison study of excimer laser versus PDL for the treatment of nail psoriasis. Dermatol Ther. 2014;4:197–205.

    Article  Google Scholar 

  136. Tawifik AA. Novel treatment of nail psoriasis using the IPL: a 1-year follow-up study. Dermatol Surg. 2014;1:1–6.

    Google Scholar 

  137. Fernández-Guarino M, Harto A, Sánchez-Ronco M, et al. Pulsed dye laser vs photodynamic therapy in the treatment of refractory nail psoriasis: a comparative pilot study. J Eur Acad Dermatol Venereol. 2009;23(8):891–5.

    Article  PubMed  Google Scholar 

  138. Rigopoulos D, Gregoriou S, Daniel CR, et al. Treatment of nail psoriasis with a two compound formulation of calcipotriol plus betamethasone dipropionate ointment. Dermatology. 2009;218:338–41.

    Article  CAS  PubMed  Google Scholar 

  139. Sanchez Regana M, Marquez Balbas G, Millet Umbert P. Nail psoriasis: a combined treatment with 8% clobetasol nail laquer and tacalcitol ointment. J Eur Acad Dermatol Venereol. 2008;22:963–9.

    Article  CAS  PubMed  Google Scholar 

  140. Huang YC, Chou CL, Chiang YY. Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. Lasers Surg Med. 2013;45(2):102–7.

    Article  PubMed  Google Scholar 

  141. Cantoresi F, Sorgi P, Arcese A, et al. Improvement of psoriatic onychodystrophy by a watersoluble nail lacquer. J Eur Acad Dermatol Venereol. 2009;23:832–4.

    Article  CAS  PubMed  Google Scholar 

  142. Vlachou C, Berth-Jones J. Nail psoriasis improvement in a patient treated with fumaric acid esters. J Dermatol Treat. 2007;18:175–7.

    Article  CAS  Google Scholar 

  143. Lindelof B. Psoriasis of the nails treated with grenz rays: a double-blind bilateral trial. Acta Derm Venereol. 1989;69(1):80–2.

    CAS  PubMed  Google Scholar 

  144. Yu RC, King CM. A double-blind study of superficial radiotherapy in psoriatic nail dystrophy. Acta Derm Venereol. 1992;72(2):134–6.

    CAS  PubMed  Google Scholar 

  145. Kwang TY, Nee TS, Seng KT. A therapeutic study of nail psoriasis using electron beam. Acta Derm Venereol. 1995;75(1):90–2.

    CAS  PubMed  Google Scholar 

  146. Ricceri F, Pescitelli L, Tripo L, et al. Treatment of severe nail psoriasis with acitretin: an impressive therapeutic result. Dermatol Ther. 2013;26(1):77–8.

    Article  CAS  PubMed  Google Scholar 

  147. Mahrle G, Schultze HG, Farber L, et al. Low- dose short-term cyclosporine versus etretinate in psoriasis: improvement of skin, nails and joint involvement. J Am Acad Dermatol. 1995;32:78–88.

    Article  CAS  PubMed  Google Scholar 

  148. Sanchez-Regana M, Sola-Ortigosa J, Gibert-Alsina J, et al. Nail psoriasis: a retrospective study on the effectiveness of systemic treatment (classical and biological therapy). J Eur Acad Dermatol Venereol. 2011;25:57–586.

    Article  CAS  Google Scholar 

  149. Ojeda R, Sanchez-Regana M, Massana J, et al. Clinical experience with the use of cyclosporine A in psoriasis, results of a retrospective study. J Dermatol Treat. 2005;16:338–41.

    Article  CAS  Google Scholar 

  150. Feliciani C, Zampetti A, Forleo P, et al. Nail psoriasis: combined therapy with systemic cyclosporine and topical calcipotriol. J Cutan Med Surg. 2004;8:122–5.

    Article  PubMed  Google Scholar 

  151. Syuto T, Abe M, Ishibuchi H, et al. Successful treatment of psoriatic nails with low-dose cyclosporine administration. Eur J Dermatol. 2007;17(3):248–9.

    PubMed  Google Scholar 

  152. Gumusel M, Ozdemir M, Mevlitoglou I, et al. Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study. J Eur Acad Dermatol Venereol. 2011;25:1080–4.

    Article  CAS  PubMed  Google Scholar 

  153. Lee JY. Severe 20-nail psoriasis successfully treated by low dose methotrexate. Dermatol Online. 2009;15(11):8–11.

    Google Scholar 

  154. Reich N, Nestle FO, Papp K, et al. Infliximab induction and maintenance therapy for moderate to- severe psoriasis: a phase III multicentre double-blind trial. Lancet. 2005;366:1367–74.

    Article  CAS  PubMed  Google Scholar 

  155. Saricaoglu H, Oz A, Turan H. Nail psoriasis successfully treated with intralesional methotrexate: case report. Dermatology. 2011;222(1):5–7.

    Article  PubMed  Google Scholar 

  156. Kyriakou A, Patsatsi A, Sotiriadis D. Anti-TNF agents and nail psoriasis: a single-center, retrospective, comparative study. J Dermatol Treat. 2013;24(3):162–8.

    Article  CAS  Google Scholar 

  157. Bardazzi F, Antonucci V, Odorici G, et al. A 36-week retrospective open trial comparing the efficacy of biological therapies in nail psoriasis. J Dtsch Dermatol Ges. 2013;11:1065–70.

    PubMed  Google Scholar 

  158. Cassetty CT, Alexis AF, Shupack JL, et al. Alefacept in the treatment of psoriatic nail disease: a small case series. J Am Acad Dermatol. 2005;52(6):1101–2.

    Article  PubMed  Google Scholar 

  159. Körver JE, Langewouters AM, Van De Kerkhof PC, et al. Therapeutic effects of a 12-week course of Alefacept on nail psoriasis. J Eur Acad Dermatol Venereol. 2006;20(10):1252–5.

    Article  PubMed  Google Scholar 

  160. Parrish CA, Sobera JO, Robbins CM, et al. Alefacept in the treatment of psoriatic nail disease: a proof of concept study. J Drugs Dermatol. 2006;5(4):339–40.

    PubMed  Google Scholar 

  161. Oram Y, Akkaya D. Treatment of nail psoriasis: common concepts and new trends. Dermatol Res Pract. 2013;2013:180496.

    Article  Google Scholar 

  162. Luger TA, Barker J, Lambert J, et al. Sustained improvement in joint pain and nail symptoms with etanercept therapy in patients with moderate-to-severe psoriasis. J Eur Acad Dermatol Venereol. 2009;23(8):896–904.

    Article  CAS  PubMed  Google Scholar 

  163. Ortonne JP, Paul C, Berardesca E, et al. A 24-week randomized clinical trial investigating the efficacy and safety of two doses of etanercept in nail psoriasis. Br J Dermatol. 2013;168(5):1080–7.

    Article  CAS  PubMed  Google Scholar 

  164. Van den Bosch F, Manger B, Goupille P, et al. Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesions. Ann Rheum Dis. 2010;69(2):394–9.

    Article  PubMed  CAS  Google Scholar 

  165. Rigopoulos D, Gregoriou S, Lazaridou E, et al. Treatment of nail psoriasis with adalimumab. An open label, uncontrolled study. J Eur Acad Dermatol Venereol. 2010;24(5):530–4.

    Article  CAS  PubMed  Google Scholar 

  166. Leonardi C, Langley RG, Papp K, et al. Adalimumab for the treatment of moderate to severe chronic plaque psoriasis of the hands and feet: efficacy and safety results from REACH a randomized, placebo-controlled, double-blind trial. Arch Dermatol. 2011;147(4):429–36.

    Article  CAS  PubMed  Google Scholar 

  167. Thaci D, Unnebrink K, Sundaram M, et al. Adalimumab for the treatment of moderate to severe psoriasis: subanalysis of effects on scalp and nails in the BELIEVE study. JEADV. 2015;29:353–60.

    CAS  PubMed  Google Scholar 

  168. Rich P, Griffiths C, Reich K, et al. Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with Infliximab during 1 year. J Am Acad Dermatol. 2008;58:224–31.

    Article  PubMed  Google Scholar 

  169. Rigopoulos D, Gregoriou S, Stratigos A, et al. Evaluation of the efficacy and safety of Infliximab on psoriatic nails: an unblinded, non-randomized, open-label study. Br J Dermatol. 2008;159(2):453–6.

    Article  CAS  PubMed  Google Scholar 

  170. Torii H, Nakagawa H. Infliximab monotherapy in Japanese patients with moderate-to-severe plaque psoriasis and psoriatic arthritis. A randomized, double-blind, placebo-controlled multicenter trial. J Dermatol Sci. 2010;59:40–9.

    Article  CAS  PubMed  Google Scholar 

  171. Fabroni C, Gori A, Troiano M, et al. Infliximab efficacy in nail psoriasis. A retrospective study in 48 patients. J Eur Acad Dermatol Venereol. 2011;25:549–63.

    Article  CAS  PubMed  Google Scholar 

  172. Rich P, Bourcier M, Sofen H, et al. Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. Br J Dermatol. 2014;170:398–407.

    Article  CAS  PubMed  Google Scholar 

  173. Rigopoulos D, Gregoriou S, Makris M, Ioannides D. Efficacy of Ustekinumab in nail psoriasis and improvement in nail associated QoL in a population treated with ustekinumab for cutaneous psoriasis. An open prospective unblinded study. Dermatology. 2011;223(4):325–9.

    Article  CAS  PubMed  Google Scholar 

  174. Rallis E, Kintziglou S, Verros C. Ustekinumab for rapid treatment of nail psoriasis. Arch Dermatol. 2010;146(11):1315–6.

    Article  PubMed  Google Scholar 

  175. Igarashi A, Kato T, Kato M, et al. Efficacy and safety of ustekinumab in Japanese patients with moderate-to-severe plaque-type psoriasis: long-term results from a phase 2/3 clinical trial. J Dermatol. 2012;39:242–52.

    Article  CAS  PubMed  Google Scholar 

  176. Vitiello M, Tosti A, Abuchar A, et al. Ustekinumab for the treatment of nail psoriasis in heavily treated psoriatic patients. Int J Dermatol. 2013;52:358–62.

    Article  CAS  PubMed  Google Scholar 

  177. Patsatsi A, Kyriakou A, Sotiriadis D. Ustekinumab in nail psoriasis: an open-label, uncontrolled, nonrandomized study. J Dermatolog Treat. 2013;24:96–100.

    Article  CAS  PubMed  Google Scholar 

  178. Paul C, Reich K, Gottlieb AB. Secukinumab improves hand, foot and nail lesions in moderate-to-severe plaque psoriasis: subanalysis of a randomized, double-blind, placebo-controlled, regimen-finding phase 2 trial. J EADV. 2014;28(12):1670–5.

    CAS  Google Scholar 

  179. Reich K, Sullivan J, Arenberger P, et al. Secukinumab is effective in subjects with moderate to severe plaque psoriasis with significant nail involvement: 16 weeks results from the TRANSFIGURE study. Poster 23rd World Congress of Dermatology, Vancouver, Canada. 2015.

    Google Scholar 

  180. Langley GR, Rich P, Menter A, et al. Improvement of scalp and nail lesions with ixekizumab in a phase 2 trial in patients with chronic plaque psoriasis. JEADV. 2015;29(9):1763–70.

    CAS  PubMed  Google Scholar 

  181. Rich P, Gooderham M, Bachelez H, et al. Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with difficult-to-treat nail and scalp psoriasis: results of 2 phase III randomized, controlled trials (ESTEEM 1 and ESTEEM 2). JAAD. 2016;74(1):134–14.

    Article  CAS  PubMed  Google Scholar 

  182. Brazzelli V, Carugno A, Alborghetti A, Grasso V, Cananzi R, Fornara L, et al. Prevalence, severity and clinical features of psoriasis in fingernails and toenails in adult patients: Italian experience. J Eur Acad Dermatol Venereol. 2012;26(11):1354–9.

    Article  CAS  PubMed  Google Scholar 

  183. Wilson FC, Icen M, Crowson CS, McEvoy MT, Gabriel SE, Kremers HM. Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study. Arthritis Rheum. 2009;61(2):233–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  184. Tan AL, Grainger AJ, Tanner SF, Emery P, McGonagle D. A high-resolution magnetic resonance imaging study of distal interphalangeal joint arthropathy in psoriatic arthritis and osteoarthritis: are they the same? Arthritis Rheum. 2006;54(4):1328–33.

    Article  PubMed  Google Scholar 

  185. Tan AL, Benjamin M, Toumi H, Grainger AJ, Tanner SF, Emery P, et al. The relationship between the extensor tendon enthesis and the nail in distal interphalangeal joint disease in psoriatic arthritis – a high-resolution MRI and histological study. Rheumatology (Oxford). 2007;46(2):253–6.

    Article  CAS  Google Scholar 

  186. Scarpa R, Soscia E, Peluso R, Atteno M, Manguso F, Del Puente A, et al. Nail and distal interphalangeal joint in psoriatic arthritis. J Rheumatol. 2006;33(7):1315–9.

    PubMed  Google Scholar 

  187. Aydin SZ, Castillo-Gallego C, Ash ZR, Marzo-Ortega H, Emery P, Wakefield RJ, et al. Ultrasonographic assessment of nail in psoriatic disease shows a link between onychopathy and distal interphalangeal joint extensor tendon enthesopathy. Dermatology. 2012;225(3):231–5.

    Article  PubMed  Google Scholar 

  188. Aydin SZ, Ash ZR, Tinazzi I, Castillo-Gallego C, Kwok C, Wilson C, et al. The link between enthesitis and arthritis in psoriatic arthritis: a switch to a vascular phenotype at insertions may play a role in arthritis development. Ann Rheum Dis. 2013;72(6):992–5.

    Article  PubMed  Google Scholar 

  189. Shbeeb M, Uramoto KM, Gibson LE, O’Fallon WM, Gabriel SE. The epidemiology of psoriatic arthritis in Olmsted County, Minnesota, USA, 1982–1991. J Rheumatol. 2000;27(5):1247–50.

    CAS  PubMed  Google Scholar 

  190. Zachariae H. Prevalence of joint disease in patients with psoriasis: implications for therapy. Am J Clin Dermatol. 2003;4(7):441–7.

    Article  PubMed  Google Scholar 

  191. Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol. 2005;141(12):1537–41.

    Article  PubMed  Google Scholar 

  192. Gladman DD, Shuckett R, Russell ML, Thorne JC, Schachter RK. Psoriatic arthritis (PSA) – an analysis of 220 patients. Q J Med. 1987;62(238):127–41.

    CAS  PubMed  Google Scholar 

  193. Moll JM, Wright V. Psoriatic arthritis. Semin Arthritis Rheum. 1973;3(1):55–78.

    Article  CAS  PubMed  Google Scholar 

  194. Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum. 2006;54(8):2665–73.

    Article  PubMed  Google Scholar 

  195. Khraishi M, Chouela E, Bejar M, Landells I, Hewhook T, Rampakakis E, et al. High prevalence of psoriatic arthritis in a cohort of patients with psoriasis seen in a dermatology practice. J Cutan Med Surg. 2012;16(2):122–7.

    Article  PubMed  Google Scholar 

  196. Haroon M, Kirby B, FitzGerald O. High prevalence of psoriatic arthritis in patients with severe psoriasis with suboptimal performance of screening questionnaires. Ann Rheum Dis. 2013;72(5):736–40.

    Article  PubMed  Google Scholar 

  197. Ibrahim GH, Buch MH, Lawson C, Waxman R, Helliwell PS. Evaluation of an existing screening tool for psoriatic arthritis in people with psoriasis and the development of a new instrument: the Psoriasis Epidemiology Screening Tool (PEST) questionnaire. Clin Exp Rheumatol. 2009;27(3):469–74.

    CAS  PubMed  Google Scholar 

  198. Gladman DD, Schentag CT, Tom BD, Chandran V, Brockbank J, Rosen C, et al. Development and initial validation of a screening questionnaire for psoriatic arthritis: the Toronto Psoriatic Arthritis Screen (ToPAS). Ann Rheum Dis. 2009;68(4):497–501.

    Article  CAS  PubMed  Google Scholar 

  199. Husni ME, Meyer KH, Cohen DS, Mody E, Qureshi AA. The PASE questionnaire: pilot- testing a psoriatic arthritis screening and evaluation tool. J Am Acad Dermatol. 2007;57(4):581–7.

    Article  PubMed  Google Scholar 

  200. Alenius GM, Stenberg B, Stenlund H, Lundblad M, Dahlqvist SR. Inflammatory joint manifestations are prevalent in psoriasis: prevalence study of joint and axial involvement in psoriatic patients, and evaluation of a psoriatic and arthritic questionnaire. J Rheumatol. 2002;29(12):2577–82.

    PubMed  Google Scholar 

  201. Tinazzi I, Adami S, Zanolin EM, Caimmi C, Confente S, Girolomoni G, et al. The early psoriatic arthritis screening questionnaire: a simple and fast method for the identification of arthritis in patients with psoriasis. Rheumatology (Oxford). 2012;51(11):2058–63.

    Article  Google Scholar 

  202. Ash Z, Gaujoux-Viala C, Gossec L, Hensor EM, FitzGerald O, Winthrop K, et al. A systematic literature review of drug therapies for the treatment of psoriatic arthritis: current evidence and meta-analysis informing the EULAR recommendations for the management of psoriatic arthritis. Ann Rheum Dis. 2012;71(3):319–26.

    Article  CAS  PubMed  Google Scholar 

  203. Ash Z, Aydin SZ, Tan AL, McGonagle D. Arthritis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 34–41.

    Google Scholar 

  204. Piraccini BM, Starace M. Nail psoriasis in special populations: children, pregnant, elderly. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 132–46.

    Google Scholar 

  205. Piraccini BM, Triantafyllopoulou I, Prevezas C, Starace M, Neri I, Patrizi A, Caserini M, Palmieri R, Rigopoulos D. Nail psoriasis in children: common or uncommon? Results from a 10-year double-center study. Skin Appendage Disord. 2015;1:43–8.

    Article  PubMed  PubMed Central  Google Scholar 

  206. Iorizzo M, Vincenzi C, Smith FJ, Wilson NJ, Tosti A. Pachyonychia congenita type I presenting with subtle nail changes. Pediatr Dermatol. 2009;26:492–3.

    Article  PubMed  Google Scholar 

  207. Tosti A, Peluso AM, Zucchelli V. Clinical features and long-term follow-up of 20 cases of parakeratosis pustulosa. Pediatr Dermatol. 1998;15:259–63.

    Article  CAS  PubMed  Google Scholar 

  208. Gordon KA, Vega JM, Tosti A. Trachyonychia: a comprehensive review. Indian J Dermatol Venereol Leprol. 2011;77:640–5.

    Article  PubMed  Google Scholar 

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Rigopoulos, D., Gregoriou, S. (2018). Nail Unit Psoriasis. In: Rubin, A.I., Jellinek, N.J., Daniel, C.R., Scher, R.K. (eds) Scher and Daniel’s Nails. Springer, Cham. https://doi.org/10.1007/978-3-319-65649-6_6

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