Abstract
Prevalence of nail psoriasis ranges from 7% to 56%, in psoriatic patients and significantly burdens quality of life. Nail psoriasis is associated with psoriatic arthritis and may be secondary to inflammation of the enthesis around the distal interphalangeal joint. Clinical features present due to inflammation of either the nail matrix or the nail bed and include pitting, leukonychia, red spots in the lunula, crumbling, onycholysis, splinter hemorrhages, subungual hyperkeratosis, and oil-drop salmon patches. Management of nail psoriasis should be individualized, and this depends on the number of nails affected, involvement of skin and/or joints, and co morbidities that might affect the choice of topical or systemic therapies.
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References
de Berker DAR, Baran R, Dawber RPR. The nail in dermatological diseases. In: Baran R, Dawber RPR, de Berker DAR, Haneke E, Tosti A, editors. Baran and Dawber’s diseases of the nails and their management. 3rd ed. Malden: Blackwell Science; 2001. p. 172–222.
Richert B, Caucanas M. Epidemiology of nail psoriasis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis From A to Z. Switzerland: Springer International Publishing; 2014. p. 1–11.
McGonagle D. Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease. J Eur Acad Dermatol Venereol. 2009;23(Suppl 1):9–13.
Radtke MA, Langenbruch AK, Schäfer I, Herberger K, Reich K, Augustin M. Nail psoriasis as a severity indicator: results from the PsoReal study. Patient Relat Outcome Meas. 2011;2:1–6.
Augustin M, Reich K, Blome C, et al. Nail psoriasis in Germany: epidemiology and burden of disease. Br J Dermatol. 2010;163:580–5.
Ortonne JP, Baran R, Corvest M, et al. Development and validation of nail psoriasis quality of life scale (NPQ10). J Eur Acad Dermatol Venereol. 2010;24:22–7.
Belyayeva E, Gregoriou S, Chalikias J, Kontochristopoulos G, Koumantaki E, Makris M, Koti I, Katoulis A, Katsambas A, Rigopoulos D. The impact of nail disorders on quality of life. Eur J Dermatol. 2013;23(3):366–71.
Rich P, Griffiths CE, Reich K, Nestle FO, Scher RK, Li S, Xu S, Hsu MC, Guzzo C, et al. Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. J Am Acad Dermatol. 2008;58(2):224–31.
Baran R, Tosti A. Nails. In: Fitzpatrick TB, Freedberg IM, editors. Fitzpatrick’s dermatology in general medicine, vol. I. 6th ed. New York: McGraw-Hill, Medical Pub. Division; 2003.
van der Velden HM, Klaassen KM, van de Kerkhof PC, Pasch MC. Fingernail psoriasis reconsidered: a case-control study. J Am Acad Dermatol. 2013;69(2):245–52.
Palmou N, Marzo-Ortega H, Ash Z, Goodfield M, Coates LC, Helliwell PS, McGonagle D. Linear pitting and splinter haemorrhages are more commonly seen in the nails of patients with established psoriasis in comparison to psoriatic arthritis. Dermatology. 2011;223(4):370–3.
Puri N, Mahajan BB. Nail changes in psoriasis – a profile. J Pak Assoc Dermatol. 2011;21(3):165–9.
Brazzelli V, Carugno A, Alborghetti A, Grasso V, Cananzi R, Fornara L, De Silvestri A, Borroni G. Prevalence, severity and clinical features of psoriasis in fingernails and toenails in adult patients: Italian experience. J Eur Acad Dermatol Venereol. 2012;26(11):1354–9.
Salomon J, Szepietowski JC, Proniewicz A. Psoriatic nails: a prospective clinical study. J Cutan Med Surg. 2003;7(4):317–21.
Edwards F, de Berker D. Nail psoriasis: clinical presentation and best practice recommendations. Drugs. 2009;69(17):2351–61.
Jadhav VM, Mahajan PM, Mhaske CB. Nail pitting and onycholysis. Indian J Dermatol Venereol Leprol. 2009;75(6):631–3.
Singh SK. Fingernail pitting in psoriasis and its relation with different variables. Indian J Dermatol. 2013;58(4):310–2.
Holzberg M. Common nail disorders. Dermatol Clin. 2006;24(3):349–54.
Baran RL. A nail psoriasis severity index. Br J Dermatol. 2004;150:568–9.
Baran R, Dawber RPR. Baran and Dawber’s diseases of the nails and their management. 3rd ed. Malden: Blackwell Science; 2001.
Wilkerson MG, Wilkin JK. Red lunulae revisited: a clinical and histopathologic examination. J Am Acad Dermatol. 1989;20(3):453–7.
de Berker D. Erythronychia. Dermatol Ther. 2012;25(6):603–11.
Lesher JL Jr, Peterson CM, Lane JE. An unusual case of factitious onychodystrophy. Pediatr Dermatol. 2004;21(3):239–41.
Jiaravuthisan MM, Sasseville D, Vender RB, Murphy F, Muhn CY. Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy. J Am Acad Dermatol. 2007;57(1):1–27.
Baran R, Dawber RPR, Haneke E, Tosti A, Bristow I. A text atlas of nails disorders: techniques in investigation and diagnosis. 3rd ed. London: Martin Dunitz; 2003.
Zaias N. Psoriasis of the nail: a clinical-pathologic study. Arch Dermatol. 1969;99(5):567–79.
Daniel CR 3rd, Iorizzo M, Piraccini BM, Tosti A. Grading simple chronic paronychia and onycholysis. Int J Dermatol. 2006;45(12):1447–8.
Tosti A, Piraccini B. Chapter 89: Biology of nails and nails disorders. In: Wolff K, editor. Fitzpatrick’s dermatology in general medicine. New York: McGraw-Hill; 2012.
Jackson RH. Splinter haemorrhages in the fingernails. Br Med J. 1963;2(5371):1485–6.
Bloom R, Tosti A. The clinical features of nail psoriasis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 44–55.
Tosti A, Piraccini B. Dermatological diseases that affect the nail. In: Hordinsky MK, Sawaya M, Scher RK, editors. Atlas of hair and nails. Philadelphia: Saunders; 2000. p. xii. 252 p.
Kouskoukis CE, Scher RK, Ackerman AB. The “oil drop” sign of psoriatic nails. Am J Dermatopathol. 1983;5(3):259–62.
Zaiac MN, Weiss E. Mohs micrographic surgery of the nail unit and squamous cell carcinoma. Dermatol Surg. 2001;27(3):246–51.
Zaias N. The nail in health and disease. 2nd ed. Norwalk: Appleton & Lange; 1990.
Tham SN, Lim JJ, Tay SH, Chiew YF, Chua TN, Tan E, Tan T. Clinical observations on nail changes in psoriasis. Ann Acad Med Singap. 1988;17:482–5.
Dogra A, Arora AK. Nail psoriasis: the journey so far. Indian J Dermatol. 2014;59(4):319–33.
Piraccini BM, Bruni F, Starace M. Dermoscopy of non-skin cancer nail disorders. Dermatol Ther. 2012;25(6):594–602.
Gewirtzman AJ, Saurat JH, Braun RP. An evaluation of dermoscopy fluids and application techniques. Br J Dermatol. 2003;149(1):59–63.
Tosti APB, Farias DC. Nail dermoscopy. In: Micali G, editor. Videodermatoscopy in clinical practice. London: Informa Healthcare; 2009.
Farias DC, Tosti A, Chiacchio ND, Hirata SH. Dermoscopy in nail psoriasis. An Bras Dermatol. 2010;85(1):101–3.
Patel S, Tosti A. Dermoscopy of nail psoriasis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis. From A to Z. Switzerland: Springer International publishing; 2014. p. 65–71.
Iorizzo M, Dahdah M, Vincenzi C, Tosti A. Videodermoscopy of the hyponychium in nail bed psoriasis. J Am Acad Dermatol. 2008;58(4):714–5.
Ohtsuka T, Yamakage A, Miyachi Y. Statistical definition of nail fold capillary pattern in patients with psoriasis. Int J Dermatol. 1994;33(11):779–82.
Zaric D, Clemmensen OJ, Worm AM, Stahl D. Capillary microscopy of the nail fold in patients with psoriasis and psoriatic arthritis. Dermatologica. 1982;164(1):10–4.
Bhushan M, Moore T, Herrick AL, Griffiths CE. Nail fold video capillaroscopy in psoriasis. Br J Dermatol. 2000;142(6):1171–6.
Lencastre A, Lamas A, Sá D, Tosti A. Onychoscopy. Clin Dermatol. 2013;31(5):587–93.
Micali G, Lacarrubba F. Possible applications of videodermatoscopy beyond pigmented lesions. Int J Dermatol. 2003;42:430–3.
Wortsman X, Soto R. Ultrasound imaging of psoriatic nails. In: Rigopoulos D, Tosti A, editors. Nail psoriasis. From A to Z. Switzerland: Springer International publishing; 2014. p. 58–63.
Gisondi P, Idolazzi L, Girolomoni G. Ultrasonography reveals nail thickening in patients with chronic placque psoriasis. Arch Dermatol Res. 2012;304(9):727–32.
Aydin SZ, Castillo-Gallego C, Ash ZR, Abignano G, Marzo-Ortega H, Wittmann M, Del Galdo F, McGonagle D. Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. Dermatology. 2013;227(1):45–51.
Aydin SZ, Ash Z, Del Galdo F, Marzo-Ortega H, Wakefield RJ, Emery P, McGonagle D. Optical coherence tomography: a new tool to assess nail disease in psoriasis? Dermatology. 2011;222(4):311–3.
Ribeiro CF, Holler AP, Skake TL. Periungual capillascopy in psoriasis. Ana Bras Dermatol. 2012;87(4):550–3.
Zaric D, Clemmerson Q, Worm A, Stahl D. Capillary microscopy of the nail fold in patients with psoriasis and psoriatic arthritis. Dermatologica. 1982;164:10–4.
Salli L, Raimondi F, Pappalardo A. Periungual capillaroscopy in psoriatic arthritis. Clin Ter. 1999;150:409–12.
Tan ES, Chong WS, Tey HL. Nail psoriasis: a review. Am J Clin Dermatol. 2012;13:375–88.
Jadhav VM, Mahajan PM, Mhaske CB. Nail pitting and onycholysis. Indian J Dermatol Venereol. 2009;75:631–3.l.
Tosti A, Piraccani B. Dermatologic diseases. In: Scher RK, editor. Nails diagnosis, therapy and surgery. 3rd ed. Philadelphia: Saunders; 2005. p. 116.
Yin N, Tosti A. Differential diagnosis for nail psoriasis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 86–95.
Yung A, Johnson P, Goodfield MJ. Isotretinoin-induced elkonyxis. Br J Dermatol. 2005;153:671–2.
Greene RA, Scher RK. Nail changes associated with diabetes mellitus. J Am Acad Dermatol. 1987;16:1015–21.
Baran R, Dawber RPR, Haneke E, Tosti A. Nail plate and soft tissue abnormalities. In: Baran R, Dawber RPR, Haneke E, Tosti A, Bristow I, Thomas L, et al., editors. A text atlas of nail disorders – techniques in investigation and diagnosis. London: Taylor & Francis; 2003.
Tosti A, Piraccani BM. Nail disorders. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. Cambridge: Mosby Elsevier; 2012. cap. 70. p. 1019–36.
Tosti A, Daniel R, Piraccani B, Iorizzo M. Color atlas of nails. 1st ed. Berlin: Springer; 2009.
Daniel CR 3rd, Iorizzo M, Piraccini BM, Tosti A. Simple onycholysis. Cutis. 2011;87:226–8.
Dawber RP, Samman PD, Bottoms E. Fingernail growth in idiopathic and psoriatic onycholysis. Br J Dermatol. 1971;85:558–60.
Natarajan V, Nath AK, Thappa DM, Singh R, Verma SK. Coexistence of onychomycosis in psoriatic nails: a descriptive study. Indian J Dermatol Venereol Leprol. 2010;76:723.
Sigurgeirsson B, Steingrimsson O. Risk factors associated with onychomycosis. J Eur Acad Dermatol Venereol. 2004;18:48–51.
Kacar N, Ergin S, Ergin C, Erdogan BS, Kaleli I. The prevalence, aetiological agents and therapy of onychomycosis in patients with psoriasis: a prospective controlled trial. Clin Exp Dermatol. 2007;32:1–5.
Gupta AK, Lynde CW, Jain HC, Sibbald RG, Elewski BE, Daniel CR 3rd, Watteel GN, Summerbell RC. A higher prevalence of onychomycosis in psoriatics compared with non-psoriatics: a multicentre study. Br J Dermatol. 1997;136:786–9.
Klaassen KM, Dulak MG, van de Kerkhof PC, Pasch MC. The prevalence of onychomycosis in psoriatic patients: a systematic review. J Eur Acad Dermatol Venereol. 2014;28(5):533–41.
Larsen GK, Haedersdal M, Svejgaard EL. The prevalence of onychomycosis in patients with psoriasis and other skin diseases. Acta Derm Venereol. 2003;83(3):206–9.
Dorschner RA, Lopez-Garcia B, Massie J, Kim C, Gallo RL. Innate immune defense of the nail unit by antimicrobial peptides. J Am Acad Dermatol. 2004;50(3):343–8.
Minisini AM, Tosti A, Sobrero AF, Mansutti M, Piraccini BM, Sacco C, et al. Taxane-induced nail changes: incidence, clinical presentation and outcome. Ann Oncol. 2003;14:333–7.
Gregoriou S, Karagiorga T, Stratigos A, Volonakis K, Kontochristopoulos G, Rigopoulos D. Photo-onycholysis caused by olanzapine and aripiprazole. J Clin Psychopharmacol. 2008;28:219–20.
Baran R, Juhlin L. Photoonycholysis. Photodermatol Photoimmunol Photomed. 2002;18:202–7.
Baran R, Juhlin L. Drug-induced photo-onycholysis. Three subtypes identified in a study of 15 cases. J Am Acad Dermatol. 1987;17:1012–6.
Gregoriou S, Argyriou G, Larios G, Rigopoulos D. Nail disorders and systemic disease: what the nails tell us. J Fam Pract. 2008;57:509–14.
Gregoriou S, Papafragkaki D, Rigopoulos D. Nails. In: Hall JC, Hall BJ, editors. Hall’s manual of skin as a marker of underlying disease: Shelton Connecticut USA: People’s medical publishing house; 2011. p. 207–26.
Scher RK, Daniel R. Nails: therapy, diagnosis, and surgery. Philadelphia: W.B. Sanders Company; 1990.
Blum M, Aviram A. Splinter hemorrhages in patients receiving regular hemodialysis. JAMA. 1978;239:47.
Kelly MP, Kight MA, Castillo S. Trophic implications of altered body composition observed in or near the nails of hemodialysis patients. Adv Ren Replace Ther. 1998;M5:241–51.
Sanders CV, Saenz RE, Lopez M. Splinter hemorrhages and onycholysis: unusual reactions associated with tetracycline hydrochloride therapy. South Med J. 1976;69:1090–2.
Mortimer PS, Dawber RP. Trauma to the nail unit including occupational sports injuries. Dermatol Clin. 1985;3:415–20.
Saladi RN, Persaud AN, Rudikoff D, Cohen SR. Idiopathic splinter hemorrhages. J Am Acad Dermatol. 2004;50:289–92.
Kouskoukis CE, Scher RK, Ackerman AB. The “oil drop” sign of psoriatic nails. A clinical finding specific for psoriasis. Am J Dermatopathol. 1983;5:259–62.
Haneke E. Nail psoriasis. In: Soung J, Koo B, editors. Psoriasis. Rijeka: Intech; 2011. 978-953-307-878.
Haneke E. Pathology. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 15–21.
Piraccini BM, Fanti PA, Morelli R, Tosti A. Hallopeau’s acrodermatitis continua of the nail: a clinical and pathological study of 20 patients. Acta Derm Venereol. 1994;74(1):65–7.
Rigopoulos D, Prevezas C. Severity evaluation indexes. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 1–11.
Pierard GE, Pierard-Franchmimont C. Dynamics of psoriatic trachyonychia during low-dose cyclosporine-A treatment: a pilot study on onychochronobiology using optical profilometry. Dermatology. 1996;192:116–9.
Rich P, Scher R. Nail psoriasis severity-index: a useful tool for evaluation of nail psoriasis. J Am Acad Dermatol. 2003;49:206–12.
Rigopoulos D, Gregoriou S, Makris M, et al. Efficacy of Ustekinumab in nail psoriasis and improvement in nail-associated quality of life in a population treated with Ustekinumab for cutaneous psoriasis: an open prospective unblinded study. Dermatology. 2011;223(4):325–9.
Tosti A, Ricotti C, Romanelli P, et al. Evaluation of the efficacy of Acitretin therapy for nail psoriasis. Arch Dermatol. 2009;145(3):269–71.
Bianchi L, Bergamin A, de Felice C, et al. Remission and time of resolution of nail psoriasis during infliximab therapy. J Am Acad Dermatol. 2005;52(4):736–7.
Bardazzi F, Antonucci VA, Tengattini V, et al. A 36-week retrospective open trial comparing the efficacy of biological therapies in nail psoriasis. J Dtsch Dermatol Ges. 2013;11(11):1065–70.
Cassell SE, et al. The modified nail psoriasis severity index: validation of an instrument to assess psoriatic nail involvement in patients with psoriatic arthritis. J Rheumatol. 2007;34:123–9.
Aktan S, Ilknur T, Akin C, et al. Inter-observer reliability of the nail psoriasis severity index. Clin Exp Dermatol. 2007;32:141–4.
Parrish CA, Sobera JO, Elewski BO. Modification of nail psoriasis severity index. J Am Acad Dermatol. 2005;53(4):745–6. author reply 746–7
Augustin M, Blome C, Costanzo A, et al. Nail Assessment in Psoriasis and Psoriatic Arthritis (NAPPA): development and validation of a tool for assessment of nail psoriasis outcomes. Br J Dermatol. 2014;170(3):591–8.
Oran Y, Akkaya D. Treatment of nail psoriasis: common concepts and new trends. Dermatol Res Pract. 2013;23:1–13.
Gregoriou S, Kalogeromitros D, Kosionis N, et al. Treatment options for nail psoriasis. Exp Rev Dermatol. 2008;3(3):339–44.
Radtke A, Beikert F, Augustin M. Nail psoriasis-a treatment challenge. J Dtsch Dermatol Ges. 2013;103:203–19.
Reich K. Approach to managing patients with nail psoriasis. J Eur Acad Dermatol Venereol. 2009;23(Suppl 1):15–21.
Jaravuthisan M, Sasseville D, Vender R, et al. Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy. J Am Acad Dermatol. 2007;57:1–27.
Dehesa L, Tosti A. Treatment of inflammatory nail disorders. Dermatol Ther. 2012;25:525–34.
Cannavo SP, Guarneri F, Vaccaro M, et al. Treatment of psoriatic nails with topical cyclosporine: a prospective randomized, placebo-controlled study. Dermatology. 2003;206:153–6.
De Berker D, Lawrence CM. A simplified protocol of steroid injection for psoriatic nail dystrophy. Br J Dermatol. 1998;138:90–5.
De Berker D. Management of psoriatic nail disease. Semin Cutan Med Surg. 2009;28:39–43.
Saleem K, Azim W. Treatment of nail psoriasis with a modified regimen of steroid injections. J Coll Physicians Surg Pak. 2008;18(2):78–81.
De Berker D. Management of nail psoriasis. Clin Exp Dermatol. 2000;25:357–62.
Scher RK, Daniel CR. Nails: therapy, diagnosis, surgery. Philadelphia: W.B. Saunders Company; 2003.
Baran R, Tosti A. Treatment of nail psoriasis with a new corticoid – containing nail lacquer formulation. J Dermatol Treat. 1999;10:201–4.
Sanchez Regana M, Martin Ezwuerra G, Millet U, et al. Treatment of nail psoriasis with 8% clobetasol nail lacquer: positive experience in 10 patients. J Eur Acad Dermatol Venereol. 2005;19:573–7.
Nakamura R, Duque-Estrada B, Pizzaro Leverone A, et al. Comparison of nail lacquer clobetasol efficacy at 0, 05%, 1% and 8% in nail psoriasis treatment: prospective, controlled and randomized pilot study. An Bras Dermatol. 2012;87(2):203–11.
van Le Q, Howard A. Dexamethasone iontophoresis for the treatment of nail psoriasis. Aust J Dermatol. 2013;54:115–9. Tosti A, Piraccini BM, Cameli N, et al. Calcipotriol ointment in nail psoriasis: a controlled, double-blind comparison with betamethasone dipropionate and salicylic acid. Br J Dermatol. 1998;139:655–9.
Tosti A, Piraccini BM, Cameli N, et al. Calcipotriol ointment in nail psoriasis: a controlled, double-blind comparison with betamethasone dipropionate and salicylic acid. Br J Dermatol. 1998;139:655–9.
Zakeri M, Valikhani M, Mortazavi H, et al. Topical calcipotriol therapy in nail psoriasis: a study of 24 cases. Dermatol Online J. 2005;11(3):5–9.
Rigopoulos D, Ioannides D, Prastitis N, et al. Nail psoriasis: a combined treatment using calcipotriol cream and clobetasol propionate cream. Acta Dermatol Venereol. 2002;82(2):140–3.
Piraccini BM, Tosti A, Iorizzo M, et al. Pustular psoriasis of the nails: treatment and long-term follow-up of 46 patients. Br J Dermatol. 2001;144:1000–5.
Balbas-Marquez M, Sanchez-Regana M, Millet-Umbert P. Tacalcitol ointment for the treatment of nail psoriasis. J Dermatol Treat. 2009;20(5):308–10.
Kole L, Cantrell W, Elewski B. A randomized, double-blinded trial evaluating the efficacy and tolerability of vectical ointment (calcitriol 3 mcg/g ointment) when compared to betamethasone diproprionate ointment (64 mg/g) in patients with nail psoriasis. J Drugs Dermatol. 2014;13(8):912–5.
Scher RK, Stiller M, Zhu YI. Tazarotene 0.1% gel in the treatment of fingernail psoriasis: a double-blind, randomized, vehicle-controlled study. Cutis. 2001;68:355–8.
Bianchi L, Soda R, Diluvio L, et al. Tazarotene 0.1% gel for psoriasis of the fingernails and toenails: an open, prospective study. Br J Dermatol. 2003;149(1):207–9.
Rigopoulos D, Gregoriou S, Katsambas A. Treatment of psoriatic nails with Tazarotene 0.1% gel vs clobetasol propionate 0.05% cream: a double-blind study. Acta Derm Venereol. 2007;87(2):167–8.
Levancini-Fischer C, Sanchez-Regana M, Lambi F, et al. Nail psoriasis: treatment with tazarotene 0.1% hydrophilic ointment. Actas Dermosifiliogr. 2012;103(8):725–8.
Fritz K. Successful local treatment of nail psoriasis with 5-fluorouracil. Z Hautarz. 1989;15(64):1083–8.
de Jong EM, Menke HE, van Praag MC, et al. Dystrophic psoriatic fingernails treated with 1% fluorouracil in a nail-penetration-enhancing vehicle. Dermatology. 1999;199:313–8.
Yamamoto T, Katayana I, Nishioka K. Topical anthralin therapy for refractory nail psoriasis. J Dermatol. 1998;25(4):231–3.
De Simone C, Maiorino A, Tassone F, et al. Tacrolimus 0,1% ointment in nail psoriasis: a randomized, controlled, open-label study. J Eur Acad Dermatol Venereol. 2013;27:1003–6.
Hoffmann C, Plewig G. Photochemotherapie der nagelpsoriasis. Hautarzt. 1977;28:498–9.
Handfield-Jones SE, Boyle J, Harman RRM. Local PUVA treatment for nail psoriasis. Br J Dermatol. 1987;116(2):280–1.
Stern DK, Creasey AA, Quigigie J, et al. UVA and UVB penetration of normal human cadaveric fingernail plate. Arch Dermatol. 2011;147(4):439–41.
Trieewittayapoon C, Sigvahamont P, Chanprapaph K, et al. The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: a randomized, doubleblind, intrapatient left-to-right study. J Am Acad Dermatol. 2012;66:807–12.
Oram Y, Karincaoğlu Y, Koyuncu E, et al. Pulsed dye laser in the treatment of nail psoriasis. Dermatol Surg. 2010;36(3):377–81.
Al-Mutairi N, Noor T, Al-Haddad. Single blinded left-to-right comparison study of excimer laser versus PDL for the treatment of nail psoriasis. Dermatol Ther. 2014;4:197–205.
Tawifik AA. Novel treatment of nail psoriasis using the IPL: a 1-year follow-up study. Dermatol Surg. 2014;1:1–6.
Fernández-Guarino M, Harto A, Sánchez-Ronco M, et al. Pulsed dye laser vs photodynamic therapy in the treatment of refractory nail psoriasis: a comparative pilot study. J Eur Acad Dermatol Venereol. 2009;23(8):891–5.
Rigopoulos D, Gregoriou S, Daniel CR, et al. Treatment of nail psoriasis with a two compound formulation of calcipotriol plus betamethasone dipropionate ointment. Dermatology. 2009;218:338–41.
Sanchez Regana M, Marquez Balbas G, Millet Umbert P. Nail psoriasis: a combined treatment with 8% clobetasol nail laquer and tacalcitol ointment. J Eur Acad Dermatol Venereol. 2008;22:963–9.
Huang YC, Chou CL, Chiang YY. Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. Lasers Surg Med. 2013;45(2):102–7.
Cantoresi F, Sorgi P, Arcese A, et al. Improvement of psoriatic onychodystrophy by a watersoluble nail lacquer. J Eur Acad Dermatol Venereol. 2009;23:832–4.
Vlachou C, Berth-Jones J. Nail psoriasis improvement in a patient treated with fumaric acid esters. J Dermatol Treat. 2007;18:175–7.
Lindelof B. Psoriasis of the nails treated with grenz rays: a double-blind bilateral trial. Acta Derm Venereol. 1989;69(1):80–2.
Yu RC, King CM. A double-blind study of superficial radiotherapy in psoriatic nail dystrophy. Acta Derm Venereol. 1992;72(2):134–6.
Kwang TY, Nee TS, Seng KT. A therapeutic study of nail psoriasis using electron beam. Acta Derm Venereol. 1995;75(1):90–2.
Ricceri F, Pescitelli L, Tripo L, et al. Treatment of severe nail psoriasis with acitretin: an impressive therapeutic result. Dermatol Ther. 2013;26(1):77–8.
Mahrle G, Schultze HG, Farber L, et al. Low- dose short-term cyclosporine versus etretinate in psoriasis: improvement of skin, nails and joint involvement. J Am Acad Dermatol. 1995;32:78–88.
Sanchez-Regana M, Sola-Ortigosa J, Gibert-Alsina J, et al. Nail psoriasis: a retrospective study on the effectiveness of systemic treatment (classical and biological therapy). J Eur Acad Dermatol Venereol. 2011;25:57–586.
Ojeda R, Sanchez-Regana M, Massana J, et al. Clinical experience with the use of cyclosporine A in psoriasis, results of a retrospective study. J Dermatol Treat. 2005;16:338–41.
Feliciani C, Zampetti A, Forleo P, et al. Nail psoriasis: combined therapy with systemic cyclosporine and topical calcipotriol. J Cutan Med Surg. 2004;8:122–5.
Syuto T, Abe M, Ishibuchi H, et al. Successful treatment of psoriatic nails with low-dose cyclosporine administration. Eur J Dermatol. 2007;17(3):248–9.
Gumusel M, Ozdemir M, Mevlitoglou I, et al. Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study. J Eur Acad Dermatol Venereol. 2011;25:1080–4.
Lee JY. Severe 20-nail psoriasis successfully treated by low dose methotrexate. Dermatol Online. 2009;15(11):8–11.
Reich N, Nestle FO, Papp K, et al. Infliximab induction and maintenance therapy for moderate to- severe psoriasis: a phase III multicentre double-blind trial. Lancet. 2005;366:1367–74.
Saricaoglu H, Oz A, Turan H. Nail psoriasis successfully treated with intralesional methotrexate: case report. Dermatology. 2011;222(1):5–7.
Kyriakou A, Patsatsi A, Sotiriadis D. Anti-TNF agents and nail psoriasis: a single-center, retrospective, comparative study. J Dermatol Treat. 2013;24(3):162–8.
Bardazzi F, Antonucci V, Odorici G, et al. A 36-week retrospective open trial comparing the efficacy of biological therapies in nail psoriasis. J Dtsch Dermatol Ges. 2013;11:1065–70.
Cassetty CT, Alexis AF, Shupack JL, et al. Alefacept in the treatment of psoriatic nail disease: a small case series. J Am Acad Dermatol. 2005;52(6):1101–2.
Körver JE, Langewouters AM, Van De Kerkhof PC, et al. Therapeutic effects of a 12-week course of Alefacept on nail psoriasis. J Eur Acad Dermatol Venereol. 2006;20(10):1252–5.
Parrish CA, Sobera JO, Robbins CM, et al. Alefacept in the treatment of psoriatic nail disease: a proof of concept study. J Drugs Dermatol. 2006;5(4):339–40.
Oram Y, Akkaya D. Treatment of nail psoriasis: common concepts and new trends. Dermatol Res Pract. 2013;2013:180496.
Luger TA, Barker J, Lambert J, et al. Sustained improvement in joint pain and nail symptoms with etanercept therapy in patients with moderate-to-severe psoriasis. J Eur Acad Dermatol Venereol. 2009;23(8):896–904.
Ortonne JP, Paul C, Berardesca E, et al. A 24-week randomized clinical trial investigating the efficacy and safety of two doses of etanercept in nail psoriasis. Br J Dermatol. 2013;168(5):1080–7.
Van den Bosch F, Manger B, Goupille P, et al. Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesions. Ann Rheum Dis. 2010;69(2):394–9.
Rigopoulos D, Gregoriou S, Lazaridou E, et al. Treatment of nail psoriasis with adalimumab. An open label, uncontrolled study. J Eur Acad Dermatol Venereol. 2010;24(5):530–4.
Leonardi C, Langley RG, Papp K, et al. Adalimumab for the treatment of moderate to severe chronic plaque psoriasis of the hands and feet: efficacy and safety results from REACH a randomized, placebo-controlled, double-blind trial. Arch Dermatol. 2011;147(4):429–36.
Thaci D, Unnebrink K, Sundaram M, et al. Adalimumab for the treatment of moderate to severe psoriasis: subanalysis of effects on scalp and nails in the BELIEVE study. JEADV. 2015;29:353–60.
Rich P, Griffiths C, Reich K, et al. Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with Infliximab during 1 year. J Am Acad Dermatol. 2008;58:224–31.
Rigopoulos D, Gregoriou S, Stratigos A, et al. Evaluation of the efficacy and safety of Infliximab on psoriatic nails: an unblinded, non-randomized, open-label study. Br J Dermatol. 2008;159(2):453–6.
Torii H, Nakagawa H. Infliximab monotherapy in Japanese patients with moderate-to-severe plaque psoriasis and psoriatic arthritis. A randomized, double-blind, placebo-controlled multicenter trial. J Dermatol Sci. 2010;59:40–9.
Fabroni C, Gori A, Troiano M, et al. Infliximab efficacy in nail psoriasis. A retrospective study in 48 patients. J Eur Acad Dermatol Venereol. 2011;25:549–63.
Rich P, Bourcier M, Sofen H, et al. Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. Br J Dermatol. 2014;170:398–407.
Rigopoulos D, Gregoriou S, Makris M, Ioannides D. Efficacy of Ustekinumab in nail psoriasis and improvement in nail associated QoL in a population treated with ustekinumab for cutaneous psoriasis. An open prospective unblinded study. Dermatology. 2011;223(4):325–9.
Rallis E, Kintziglou S, Verros C. Ustekinumab for rapid treatment of nail psoriasis. Arch Dermatol. 2010;146(11):1315–6.
Igarashi A, Kato T, Kato M, et al. Efficacy and safety of ustekinumab in Japanese patients with moderate-to-severe plaque-type psoriasis: long-term results from a phase 2/3 clinical trial. J Dermatol. 2012;39:242–52.
Vitiello M, Tosti A, Abuchar A, et al. Ustekinumab for the treatment of nail psoriasis in heavily treated psoriatic patients. Int J Dermatol. 2013;52:358–62.
Patsatsi A, Kyriakou A, Sotiriadis D. Ustekinumab in nail psoriasis: an open-label, uncontrolled, nonrandomized study. J Dermatolog Treat. 2013;24:96–100.
Paul C, Reich K, Gottlieb AB. Secukinumab improves hand, foot and nail lesions in moderate-to-severe plaque psoriasis: subanalysis of a randomized, double-blind, placebo-controlled, regimen-finding phase 2 trial. J EADV. 2014;28(12):1670–5.
Reich K, Sullivan J, Arenberger P, et al. Secukinumab is effective in subjects with moderate to severe plaque psoriasis with significant nail involvement: 16 weeks results from the TRANSFIGURE study. Poster 23rd World Congress of Dermatology, Vancouver, Canada. 2015.
Langley GR, Rich P, Menter A, et al. Improvement of scalp and nail lesions with ixekizumab in a phase 2 trial in patients with chronic plaque psoriasis. JEADV. 2015;29(9):1763–70.
Rich P, Gooderham M, Bachelez H, et al. Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with difficult-to-treat nail and scalp psoriasis: results of 2 phase III randomized, controlled trials (ESTEEM 1 and ESTEEM 2). JAAD. 2016;74(1):134–14.
Brazzelli V, Carugno A, Alborghetti A, Grasso V, Cananzi R, Fornara L, et al. Prevalence, severity and clinical features of psoriasis in fingernails and toenails in adult patients: Italian experience. J Eur Acad Dermatol Venereol. 2012;26(11):1354–9.
Wilson FC, Icen M, Crowson CS, McEvoy MT, Gabriel SE, Kremers HM. Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study. Arthritis Rheum. 2009;61(2):233–9.
Tan AL, Grainger AJ, Tanner SF, Emery P, McGonagle D. A high-resolution magnetic resonance imaging study of distal interphalangeal joint arthropathy in psoriatic arthritis and osteoarthritis: are they the same? Arthritis Rheum. 2006;54(4):1328–33.
Tan AL, Benjamin M, Toumi H, Grainger AJ, Tanner SF, Emery P, et al. The relationship between the extensor tendon enthesis and the nail in distal interphalangeal joint disease in psoriatic arthritis – a high-resolution MRI and histological study. Rheumatology (Oxford). 2007;46(2):253–6.
Scarpa R, Soscia E, Peluso R, Atteno M, Manguso F, Del Puente A, et al. Nail and distal interphalangeal joint in psoriatic arthritis. J Rheumatol. 2006;33(7):1315–9.
Aydin SZ, Castillo-Gallego C, Ash ZR, Marzo-Ortega H, Emery P, Wakefield RJ, et al. Ultrasonographic assessment of nail in psoriatic disease shows a link between onychopathy and distal interphalangeal joint extensor tendon enthesopathy. Dermatology. 2012;225(3):231–5.
Aydin SZ, Ash ZR, Tinazzi I, Castillo-Gallego C, Kwok C, Wilson C, et al. The link between enthesitis and arthritis in psoriatic arthritis: a switch to a vascular phenotype at insertions may play a role in arthritis development. Ann Rheum Dis. 2013;72(6):992–5.
Shbeeb M, Uramoto KM, Gibson LE, O’Fallon WM, Gabriel SE. The epidemiology of psoriatic arthritis in Olmsted County, Minnesota, USA, 1982–1991. J Rheumatol. 2000;27(5):1247–50.
Zachariae H. Prevalence of joint disease in patients with psoriasis: implications for therapy. Am J Clin Dermatol. 2003;4(7):441–7.
Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol. 2005;141(12):1537–41.
Gladman DD, Shuckett R, Russell ML, Thorne JC, Schachter RK. Psoriatic arthritis (PSA) – an analysis of 220 patients. Q J Med. 1987;62(238):127–41.
Moll JM, Wright V. Psoriatic arthritis. Semin Arthritis Rheum. 1973;3(1):55–78.
Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum. 2006;54(8):2665–73.
Khraishi M, Chouela E, Bejar M, Landells I, Hewhook T, Rampakakis E, et al. High prevalence of psoriatic arthritis in a cohort of patients with psoriasis seen in a dermatology practice. J Cutan Med Surg. 2012;16(2):122–7.
Haroon M, Kirby B, FitzGerald O. High prevalence of psoriatic arthritis in patients with severe psoriasis with suboptimal performance of screening questionnaires. Ann Rheum Dis. 2013;72(5):736–40.
Ibrahim GH, Buch MH, Lawson C, Waxman R, Helliwell PS. Evaluation of an existing screening tool for psoriatic arthritis in people with psoriasis and the development of a new instrument: the Psoriasis Epidemiology Screening Tool (PEST) questionnaire. Clin Exp Rheumatol. 2009;27(3):469–74.
Gladman DD, Schentag CT, Tom BD, Chandran V, Brockbank J, Rosen C, et al. Development and initial validation of a screening questionnaire for psoriatic arthritis: the Toronto Psoriatic Arthritis Screen (ToPAS). Ann Rheum Dis. 2009;68(4):497–501.
Husni ME, Meyer KH, Cohen DS, Mody E, Qureshi AA. The PASE questionnaire: pilot- testing a psoriatic arthritis screening and evaluation tool. J Am Acad Dermatol. 2007;57(4):581–7.
Alenius GM, Stenberg B, Stenlund H, Lundblad M, Dahlqvist SR. Inflammatory joint manifestations are prevalent in psoriasis: prevalence study of joint and axial involvement in psoriatic patients, and evaluation of a psoriatic and arthritic questionnaire. J Rheumatol. 2002;29(12):2577–82.
Tinazzi I, Adami S, Zanolin EM, Caimmi C, Confente S, Girolomoni G, et al. The early psoriatic arthritis screening questionnaire: a simple and fast method for the identification of arthritis in patients with psoriasis. Rheumatology (Oxford). 2012;51(11):2058–63.
Ash Z, Gaujoux-Viala C, Gossec L, Hensor EM, FitzGerald O, Winthrop K, et al. A systematic literature review of drug therapies for the treatment of psoriatic arthritis: current evidence and meta-analysis informing the EULAR recommendations for the management of psoriatic arthritis. Ann Rheum Dis. 2012;71(3):319–26.
Ash Z, Aydin SZ, Tan AL, McGonagle D. Arthritis. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 34–41.
Piraccini BM, Starace M. Nail psoriasis in special populations: children, pregnant, elderly. In: Rigopoulos D, Tosti A, editors. Nail psoriasis from A to Z. Switzerland: Springer International Publishing; 2014. p. 132–46.
Piraccini BM, Triantafyllopoulou I, Prevezas C, Starace M, Neri I, Patrizi A, Caserini M, Palmieri R, Rigopoulos D. Nail psoriasis in children: common or uncommon? Results from a 10-year double-center study. Skin Appendage Disord. 2015;1:43–8.
Iorizzo M, Vincenzi C, Smith FJ, Wilson NJ, Tosti A. Pachyonychia congenita type I presenting with subtle nail changes. Pediatr Dermatol. 2009;26:492–3.
Tosti A, Peluso AM, Zucchelli V. Clinical features and long-term follow-up of 20 cases of parakeratosis pustulosa. Pediatr Dermatol. 1998;15:259–63.
Gordon KA, Vega JM, Tosti A. Trachyonychia: a comprehensive review. Indian J Dermatol Venereol Leprol. 2011;77:640–5.
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Rigopoulos, D., Gregoriou, S. (2018). Nail Unit Psoriasis. In: Rubin, A.I., Jellinek, N.J., Daniel, C.R., Scher, R.K. (eds) Scher and Daniel’s Nails. Springer, Cham. https://doi.org/10.1007/978-3-319-65649-6_6
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