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Chemical Approaches Towards Neurodegenerative Disease Prevention: The Role of Coupling Sugars to Phenolic Biomolecular Entities

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Coupling and Decoupling of Diverse Molecular Units in Glycosciences

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Abstract

Polyphenols are natural molecular entities exhibiting a wide variety of bioactivities including anticholinergic and/or antiamyloidogenic activities. Their low solubility is recognized as a key factor for bioavailability and their glycosylation is indeed relevant to improve the bioaccess to these molecules. In this chapter, chemical and enzymatic syntheses of glycosylated flavonoids, stilbenoids, phenylethanoids and phenylpropanoids are illustrated, covering examples that demonstrate the impact of coupling sugars to bioactive aglycones in their bioavailability and in their pharmacological activity. The chapter is focused particularly on glycosyl polyphenols with promising activities against neurodegenerative impairments, given their potential to intervene in biological processes that cause catastrophic diseases, namely the Alzheimer’s disease.

Catarina Dias and Ana M. Matos have both contributed equally to the chapter.

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  1. Faculdade de Ciências, Centro de Química E Bioquímica, Universidade de Lisboa, Ed C8, Piso 5, 1749-016, Lisbon, Portugal

    Catarina Dias, Ana M. Matos & Amélia P. Rauter

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  1. Catarina Dias
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  2. Ana M. Matos
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  3. Amélia P. Rauter
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Correspondence to Amélia P. Rauter .

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  1. Pharmaceutical Sciences Department, Wilkes University, Wilkes-Barre, Pennsylvania, USA

    Zbigniew J. Witczak

  2. Pharmaceutical Sciences Department, Nesbitt School of Pharmacy, Wilkes University, Wilkes-Barre, Pennsylvania, USA

    Roman Bielski

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Dias, C., Matos, A.M., Rauter, A.P. (2018). Chemical Approaches Towards Neurodegenerative Disease Prevention: The Role of Coupling Sugars to Phenolic Biomolecular Entities. In: Witczak, Z., Bielski, R. (eds) Coupling and Decoupling of Diverse Molecular Units in Glycosciences. Springer, Cham. https://doi.org/10.1007/978-3-319-65587-1_8

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