Abstract
An example of a specific coupling and decoupling (CAD) chemistry is described. It takes advantage of propargyl acrylate as a sacrificial unit (SU). The addition of a selected compound representing a molecular unit equipped with an azide functionality to the terminal triple bond of the SU and another compound acting as a molecular unit equipped with a thiol functionality to the conjugated double bond of the SU proceeded at very good yields. The construct containing two molecular units can be decoupled using a few different reactions and the decoupling can take place at two positions.
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Bielski, R., Witczak, Z.J., Mencer, D. (2018). Example of Sacrificial Unit Using Two Different Click Reactions in Coupling and Decoupling (CAD) Chemistry. In: Witczak, Z., Bielski, R. (eds) Coupling and Decoupling of Diverse Molecular Units in Glycosciences. Springer, Cham. https://doi.org/10.1007/978-3-319-65587-1_13
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DOI: https://doi.org/10.1007/978-3-319-65587-1_13
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