Skip to main content

Vaccine Supply Management

  • Chapter
  • First Online:
Operations Research Applications in Health Care Management

Part of the book series: International Series in Operations Research & Management Science ((ISOR,volume 262))

  • 2280 Accesses

Abstract

There are several causes such as natural or man-made disasters, malnutrition and environmental changes that may result in spread of infectious and communicable diseases which increases the risk of morbidity and mortality. Several control tools such as education and vaccination are adopted to prevent the spread of such epidemics. In this chapter, we focus on vaccination as a strong control tool and investigate the vaccine supply chains (VSCs) regarding some related challenges. The main problems of VSCs include vaccine sourcing, vaccine demand forecasting, vaccine shortages and the vaccine cold chains that suffer from the lack of mathematical modeling and precise solutions. Solving such problems may help the responsible public health organizations to improve the immunization coverage. Also, improving the efficiency and effectiveness of VSCs has a key role in a successful immunization program. Since stockpiling of vaccine supplies and VSC coordination are effective ways in on-time delivery of required vaccines and disease control interventions especially in the case of disasters and pandemics, we also review some related researches in VSC coordination contracts and appropriate stockpiling of necessary vaccines. The aim of this chapter is to classify some problems of the vaccine supply management, which has potential to be solved by the mathematical programming tools.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Notes

  1. 1.

    CVS Pharmacy is a subsidiary of the American retail and health care company CVS Health, headquartered in Woonsocket, Rhode Island. It was originally named the Consumer Value Store, and was founded in Lowell, Massachusetts in 1963.

References

  • Adida E, Dey D, Mamani H (2013) Operational issues and network effects in vaccine markets. Eur J Oper Res 231(2):414–427

    Article  Google Scholar 

  • Amarasinghe A, Wichmann O, Margolis HS, Mahoney RT (2010) Forecasting dengue vaccine demand in disease endemic and non-endemic countries. Hum Vaccin 6(9):745–753

    Article  Google Scholar 

  • Arifoglu K, Deo S, Iravani SMR (2012) Consumption externality and yield uncertainty in the influenza vaccine supply chain: Interventions in demand and supply sides. Manag Sci 58(6):1072–1091

    Article  Google Scholar 

  • Assi T-M, Brown ST, Kone S, Norman BA, Djibo A, Connor DL, Wateska AR, Rajgopal J, Slayton RB, Lee BY (2013) Removing the regional level from the Niger vaccine supply chain. Vaccine 31(26):2828–2834

    Article  Google Scholar 

  • Bleichrodt H, Quiggin J (1999) Life-cycle preferences over consumption and health: when is cost-effectiveness analysis equivalent to cost–benefit analysis? J Health Econ 18(6):681–708

    Article  Google Scholar 

  • Brito DL, Sheshinski E, Intriligator MD (1991) Externalities and compulsary vaccinations. J Public Econ 45(1):69–90

    Article  Google Scholar 

  • Brown ST, Schreiber B, Cakouros BE, Wateska AR, Dicko HM, Connor DL, Jaillard P, Mvundura M, Norman BA, Levin C (2014) The benefits of redesigning Benin’s vaccine supply chain. Vaccine 32(32):4097–4103

    Article  Google Scholar 

  • Cachon GP (2003) Supply chain coordination with contracts. Handbooks Oper Res Manag Sci 11:227–339

    Article  Google Scholar 

  • Chick SE, Mamani H, Simchi-Levi D (2008) Supply chain coordination and influenza vaccination. Oper Res 56(6):1493–1506

    Article  Google Scholar 

  • Chiu R-K, Kuo C-W (2006) A decision support model of demand forecast for national immunisation vaccines. Int J Electron Healthc 2(1):92–104

    Article  Google Scholar 

  • Chopra S, Meindl P (2003) Supply chain management: strategy, planning and operation. Pearson Education, Inc., Upper Saddle River

    Google Scholar 

  • Dai T, Cho S-H, Zhang F (2014) Contracting for on-time delivery in the US influenza vaccine supply chain. Available at SSRN 2178157

    Google Scholar 

  • Dal Moro F (2013) BCG shortage in Europe. Prev Med 2(57):146

    Article  Google Scholar 

  • Dasaklis TK, Pappis CP, Rachaniotis NP (2012) Epidemics control and logistics operations: A review. Int J Prod Econ 139(2):393–410

    Article  Google Scholar 

  • DeLaurentis P-C, Adida E, Lawley M (2008) A game theoretical approach for hospital stockpile in preparation for pandemics. Hospital 101:1

    Google Scholar 

  • DeLaurentis P-CC, Adida E, Lawley M (2009) Hospital stockpiling for influenza pandemics with pre-determined response levels. In: Service operations, logistics and informatics, 2009. SOLI'09. IEEE/INFORMS international conference on: IEEE

    Google Scholar 

  • Dhankhar P, Dasbach EJ, Elbasha EH (2009) Economics of stockpiling for an influenza pandemic. Lancet Infect Dis 9(8):459–460

    Article  Google Scholar 

  • Dhankhar P, Grabenstein JD, O’Brien MA, Dasbach EJ (2010) Cost-effectiveness of stockpiling 23-valent pneumococcal polysaccharide vaccine to prevent secondary pneumococcal infections among a high-risk population in the united states during an influenza pandemic. Clin Ther 32(8):1501–1516

    Article  Google Scholar 

  • Federgruen A, Yang N (2008) Selecting a portfolio of suppliers under demand and supply risks. Oper Res 56(4):916–936

    Article  Google Scholar 

  • Foster S, Laing R, Melgaard B, Zaffran M (2006) Ensuring supplies of appropriate drugs and vaccines. World Bank, Washington, DC

    Google Scholar 

  • Heinrich J (2001a) Flu vaccine: supply problems heighten need to ensure access for high-risk people: GAO-01-624, 15 May. US General Accounting Office, Washington, DC

    Google Scholar 

  • Heinrich J (2001b) Flu vaccine: recent supply shortages underscore ongoing challenges. Testimony before the Subcommittee on Health and the Subcommittee on Oversight and Investigations, Committee on Energy and Commerce of the House of Representatives November 18

    Google Scholar 

  • Heinrich J (2001c) Flu vaccine: steps are needed to better prepare for possible future shortages. US General Accounting Office, Washington, DC

    Google Scholar 

  • Hinman AR, Orenstein WA, Santoli JM, Rodewald LE, Cochi SL (2006) Vaccine shortages: History, impact, and prospects for the future*. Annu Rev Public Health 27:235–259

    Article  Google Scholar 

  • Hutton G, Tediosi F (2006) The costs of introducing a malaria vaccine through the expanded program on immunization in Tanzania. Am J Trop Med Hyg 75(2 suppl):119–130

    Article  Google Scholar 

  • Kaufmann JR, Miller R, Cheyne J (2011) Vaccine supply chains need to be better funded and strengthened, or lives will be at risk. Health Aff 30(6):1113–1121

    Article  Google Scholar 

  • Kempe A, Daley MF, Stokley S, Crane LA, Beaty BL, Barrow J, Babbel C, Miriam Dickinson L, Steiner JF, Berman S (2007) Impact of a severe influenza vaccine shortage on primary care practice. Am J Prev Med 33(6):486–491

    Article  Google Scholar 

  • Lemmens S, Decouttere C, Vandaele N, Bernuzzi M (2014) Integrated supply chain network design models for vaccines: a literature review. FEB Research Report KBI_1414

    Google Scholar 

  • Liu Y (2007) Mathematical models of vaccine inventory design for a breakout of epidemic disease. PAMM 7(1):2150013–2150014

    Article  Google Scholar 

  • Lloyd J, Lydon P, Ouhichi R, Zaffran M (2015) Reducing the loss of vaccines from accidental freezing in the cold chain: The experience of continuous temperature monitoring in Tunisia. Vaccine 33(7):902–907

    Article  Google Scholar 

  • Mamani H, Chick SE, Simchi-Levi D (2010) Influenza Vaccine Supply Chain with Multiple Agencies. Plant Biotechnol J 8:607–619

    Article  Google Scholar 

  • Mamani H, Chick SE, Simchi-Levi D (2013) A game-theoretic model of international influenza vaccination coordination. Manag Sci 59(7):1650–1670

    Article  Google Scholar 

  • Matthias DM, Robertson J, Garrison MM, Newland S, Nelson C (2007) Freezing temperatures in the vaccine cold chain: a systematic literature review. Vaccine 25(20):3980–3986

    Article  Google Scholar 

  • Milstien J, Batson A, Wertheimer AI (2005) Vaccines and drugs: characteristics of their use to meet public health goals. The World Bank Health, Nutrition and Population (HNP) discussion paper

    Google Scholar 

  • Mvundura M, Kien VD, Nga NT, Robertson J, Van Cuong N, Tung HT, Hong DT, Levin C (2014) How much does it cost to get a dose of vaccine to the service delivery location? Empirical evidence from Vietnam’s Expanded Program on Immunization. Vaccine 32(7):834–838

    Article  Google Scholar 

  • Mvundura M, Lorenson K, Chweya A, Kigadye R, Bartholomew K, Mohammed M, Patrick Lennon T, Mwangi S, Kirika L, Kamau P (2015) Estimating the costs of the vaccine supply chain and service delivery for selected districts in Kenya and Tanzania. Vaccine 33(23):2697–2703

    Article  Google Scholar 

  • Ordoobadi SM (2009) Development of a supplier selection model using fuzzy logic. Supply Chain Manag: Int J 14(4):314–327

    Article  Google Scholar 

  • Riewpaiboon A, Sooksriwong C, Chaiyakunapruk N, Tharmaphornpilas P, Techathawat S, Rookkapan K, Rasdjarmrearnsook A, Suraratdecha C (2015) Optimizing national immunization program supply chain management in Thailand: an economic analysis. Public Health 129:899–906

    Article  Google Scholar 

  • Rodewald LE, Orenstein WA, Mason DD, Cochi SL (2006) Vaccine supply problems: a perspective of the Centers for Disease Control and Prevention. Clin Infect Dis 42(Supplement 3):S104–S110

    Article  Google Scholar 

  • Ryman T, Dietz V (2008) The need to improve quality, rigour and dissemination of operations research. Bull World Health Organ 86(11):A–B

    Article  Google Scholar 

  • Stentoft Arlbjørn J, Pazirandeh A (2011) Sourcing in global health supply chains for developing countries: literature review and a decision making framework. Int J Phys Distrib Logist Manag 41(4):364–384

    Article  Google Scholar 

  • Tebbens RJD, Pallansch MA, Alexander JP, Thompson KM (2010) Optimal vaccine stockpile design for an eradicated disease: Application to polio. Vaccine 28(26):4312–4327

    Article  Google Scholar 

  • Tofighi S, Torabi SA, Mansouri SA (2016) Humanitarian logistics network design under mixed uncertainty. Eur J Oper Res 250(1):239–250

    Article  Google Scholar 

  • UNICEF (2012) Supplies and logistics (Vaccine forecasting). Retrieved 06.10.2015

    Google Scholar 

  • Uscher-Pines L, Barnett DJ, Sapsin JW, Bishai DM, Balicer RD (2008) A systematic analysis of influenza vaccine shortage policies. Public Health 122(2):183–191

    Article  Google Scholar 

  • VillageReach (2009) Comparison of costs incurred in dedicated and diffused vaccine logistics systems: cost-effectiveness of vaccine logistics in Cabo Delgado and Niassa Provinces, Mozambique. VillageReach, Seattle

    Google Scholar 

  • Weinstein MC, Siegel JE, Gold MR, Kamlet MS, Russell LB (1996) Cost-effectiveness in health and medicine, vol 55. Oxford University, New York

    Google Scholar 

  • WHO (2004) Mid-level management course for EPI managers, module: cold chain management: World Health Organization (WHO)

    Google Scholar 

  • WHO (2008) Immunization supply and procurement (The cycle of vaccine procurement) Retrieved 06.10.2015

    Google Scholar 

  • WHO (2014) Media centre (Influenza-seasonal). Retrieved 27.10.2015

    Google Scholar 

  • WHO (2015b) Immunization, vaccines and biologicals (Effective Vaccine Management (EVM) Initiative). Retrieved 06.10.2015

    Google Scholar 

  • WHO (2015c) Immunization, vaccines and biologicals (Immunization supply chain and logistics). Retrieved 06.10.2015

    Google Scholar 

  • WHO (2015a) Immunization supply and procurement (Demand forecasting for routine immunization). Retrieved 06.10.2015

    Google Scholar 

  • Yadav P, Lydon P, Oswald J, Dicko M, Zaffran M (2014) Integration of vaccine supply chains with other health commodity supply chains: a framework for decision making. Vaccine 32(50):6725–6732

    Article  Google Scholar 

  • Yen C, Hyde TB, Costa AJ, Fernandez K, Tam JS, Hugonnet S, Huvos AM, Duclos P, Dietz VJ, Burkholder BT (2015) The development of global vaccine stockpiles. Lancet Infect Dis 15(3):340–347

    Article  Google Scholar 

  • Zaffran M, Vandelaer J, Kristensen D, Melgaard B, Prashant Y, Antwi-Agyei KO, Lasher H (2013) The imperative for stronger vaccine supply and logistics systems. Vaccine 31:B73–B80

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Ali Torabi .

Editor information

Editors and Affiliations

Appendix A

Appendix A

Table A.1 An overview of some VCS related issues

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Shamsi G., N., Torabi, S.A. (2018). Vaccine Supply Management. In: Kahraman, C., Topcu, Y. (eds) Operations Research Applications in Health Care Management. International Series in Operations Research & Management Science, vol 262. Springer, Cham. https://doi.org/10.1007/978-3-319-65455-3_11

Download citation

Publish with us

Policies and ethics