Skip to main content

Radiobiology of Stereotactic Radiosurgery in the Treatment of Arteriovenous Malformations

  • Chapter
  • First Online:
  • 720 Accesses

Abstract

Stereotactic radiosurgery (SRS) has been defined as the use of concentrated ionizing radiation delivered to a stereotactically defined point in space [1, 2]. SRS was used to treat patients with arteriovenous malformations (AVMs) as early as the 1970s [1]. As many as 500,000 people in North America have AVMs [3]. With SRS, angiographic cures fall between 60 and 90% [3–5]. A consideration of the radiobiology of SRS will explain why tumors and vascular lesions respond to radiation differently, and why patients with AVMs are ideal candidates for radiosurgery.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Friedman WA, Bova FJ. Radiosurgery for arteriovenous malformations. Neurol Res. 2011;33(8):803–19.

    Article  PubMed  Google Scholar 

  2. Santacroce A, Kamp MA, Budach W, Hänggi D. Radiobiology of radiosurgery for the central nervous system. Biomed Res Int. 2013;2013:362761.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Quinones-Hinojosa A. Schmidek & Sweet operative neurosurgical techniques: indications, methods, and results. London: Elsevier Health Sciences; 2012.

    Google Scholar 

  4. Schneider BF, Eberhard DA, Steiner LE. Histopathology of arteriovenous malformations after gamma knife radiosurgery. J Neurosurg. 1997;87(3):352–7.

    Article  CAS  PubMed  Google Scholar 

  5. Touboul E, Al Halabi A, Buffat L, Merienne L, Huart J, Schlienger M, Lefkopoulos D, Mammar H, Missir O, Meder JF, Laurent A, Housset M. Single-fraction stereotactic radiotherapy: a dose-response analysis of arteriovenous malformation obliteration. Int J Radiat Oncol Biol Phys. 1998;41(4):855–61.

    Article  CAS  PubMed  Google Scholar 

  6. Friedman WA. Stereotactic radiosurgery of intracranial arteriovenous malformations. Neurosurg Clin N Am. 2013;24(4):561–74.

    Article  PubMed  Google Scholar 

  7. Hall EJ, Brenner DJ. The radiobiology of radiosurgery: rationale for different treatment regimes for AVMs and malignancies. Int J Radiat Oncol Biol Phys. 1993;25(2):381–5.

    Article  CAS  PubMed  Google Scholar 

  8. Pollock BE, Meyer FB. Radiosurgery for arteriovenous malformations. J Neurosurg. 2004;101(3):390–2. Discussion 392.

    Article  PubMed  Google Scholar 

  9. Song CW, Park H, Griffin RJ, Levitt SH. Technical basis of radiation therapy. Berlin: Springer; 2011.

    Google Scholar 

  10. Park H, Lyons JC, Griffin RJ, Lim BU, Song CW. Apoptosis and cell cycle progression in an acidic environment after irradiation. Radiat Res. 2000;153(3):295–304.

    Article  CAS  PubMed  Google Scholar 

  11. Karlsson B, Lindquist C, Steiner L. Prediction of obliteration after gamma knife surgery for cerebral arteriovenous malformations. Neurosurgery. 1997;40(3):425–30. Discussion 430–1.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael Schulder M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Cite this chapter

Pruitt, R., Schulder, M. (2018). Radiobiology of Stereotactic Radiosurgery in the Treatment of Arteriovenous Malformations. In: Gandhi, C., Prestigiacomo, C. (eds) Cerebrovascular and Endovascular Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-65206-1_35

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-65206-1_35

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-65204-7

  • Online ISBN: 978-3-319-65206-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics