Skip to main content
SpringerLink
Log in

Treatment of Arteriovenous Malformations with Cyanoacrylate

  • Chapter
  • First Online:
Cerebrovascular and Endovascular Neurosurgery

  • 717 Accesses

Abstract

Embolization of arteriovenous malformations (AVMs) with acrylates can play an important role in treating these complex lesions. Embolization can be performed with an acceptable safety profile when utilizing proper planning and technique. Heterogeneity among these lesions and treatment decisions and techniques vary dramatically between treating physicians and medical centers. Reported general complication rates vary from 1 to 16%, with permanent morbidity rates of 0.4–12.5% and mortality rates of 0.4–11% [1–21]. Within these reports, rates of ischemic complications range from 0.7 to12.5% [2, 7, 20, 22]. Reported hemorrhage rates range from 2 to 15% [2, 7, 14, 20, 22, 23]. These publications reflect large case series employing different embolic agents, including acrylates, and they reflect a mix of modern and discontinued techniques with higher rates of complication compared to current methods [3].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Debrun G, Vinuela F, Fox A, Drake CG. Embolization of cerebral arteriovenous malformations with bucrylate. J Neurosurg. 1982;56(5):615–27.

    Article  PubMed  CAS  Google Scholar 

  2. Deruty R, Pelissou-Guyotat I, Amat D, et al. Complications after multidisciplinary treatment of cerebral arteriovenous malformations. Acta Neurochir. 1996;138(2):119–31.

    Article  PubMed  CAS  Google Scholar 

  3. Frizzel RT, Fisher WS III. Cure, morbidity, and mortality associated with embolization of brain arteriovenous malformations: a review of 1246 patients in 32 series over a 35-year period. Neurosurgery. 1995;37(6):1031–9. Discussion 1039–1040.

    Article  PubMed  CAS  Google Scholar 

  4. Gobin YP, Laurent A, Merienne L, et al. Treatment of brain arteriovenous malformations by embolization and radiosurgery. J Neurosurg. 1996;85(1):19–28.

    Article  PubMed  CAS  Google Scholar 

  5. Hartmann A, Mast H, Mohr JP, et al. Morbidity of intracranial hemorrhage in patients with cerebral arteriovenous malformation. Stroke. 1998;29(5):931–4.

    Article  PubMed  CAS  Google Scholar 

  6. Hartmann A, Mast H, Mohr JP, et al. Determinants of staged endovascular and surgical treatment outcome of brain arteriovenous malformations. Stroke. 2005;36(11):2431–5.

    Article  PubMed  Google Scholar 

  7. Jafar JJ, Davis AJ, Berenstein A, Choi IS, Kupersmith MJ. The effect of embolization with N-butyl cyanoacrylate prior to surgical resection of cerebral arteriovenous malformations. J Neurosurg. 1993;78(1):60–9.

    Article  PubMed  CAS  Google Scholar 

  8. Jahan R, Murayama Y, Gobin YP, Duckwiler GR, Vinters HV, Vinuela F. Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients. Neurosurgery. 2001;48(5):984–95. Discussion 995–987.

    PubMed  CAS  Google Scholar 

  9. Jayaraman MV, McTaggart RA, Sachs GM, Doberstein CE. Cerebellar pial arteriovenous malformations presenting with medullary venous hypertension: imaging and endovascular treatment. J NeuroInterv Surg. 2010;2(1):38–40.

    Article  PubMed  CAS  Google Scholar 

  10. Lasjaunias P, Manelfe C, Chiu M. Angiographic architecture of intracranial vascular malformations and fistulas—pretherapeutic aspects. Neurosurg Rev. 1986;9(4):253–63.

    Article  PubMed  CAS  Google Scholar 

  11. Ledezma CJ, Hoh BL, Carter BS, Pryor JC, Putman CM, Ogilvy CS. Complications of cerebral arteriovenous malformation embolization: multivariate analysis of predictive factors. Neurosurgery. 2006;58(4):602–11. Discussion 602–611.

    Article  PubMed  Google Scholar 

  12. Meisel HJ, Mansmann U, Alvarez H, Rodesch G, Brock M, Lasjaunias P. Cerebral arteriovenous malformations and associated aneurysms: analysis of 305 cases from a series of 662 patients. Neurosurgery. 2000;46(4):793–800. Discussion 800–792.

    PubMed  CAS  Google Scholar 

  13. Meisel HJ, Mansmann U, Alvarez H, Rodesch G, Brock M, Lasjaunias P. Effect of partial targeted N-butyl-cyano-acrylate embolization in brain AVM. Acta Neurochir. 2002;144(9):879–87. Discussion 888.

    Article  PubMed  CAS  Google Scholar 

  14. Picard L, Da Costa E, Anxionnat R, et al. Acute spontaneous hemorrhage after embolization of brain arteriovenous malformation with N-butyl cyanoacrylate. J Neuroradiol. 2001;28(3):147–65.

    PubMed  CAS  Google Scholar 

  15. Picard L, Moret J, Lepoire J, et al. Endovascular treatment of intracerebral arteriovenous angiomas. Technique, indications and results. J Neuroradiol. 1984;11(1):9–28.

    PubMed  CAS  Google Scholar 

  16. Steiger HJ, Bruckmann H, Mayer T, Schmid-Elsaesser R, Zausinger S. Congested residual nidus after preoperative intranidal embolization in midsize cerebral arteriovenous malformations of 3-6 cm in diameter. Acta Neurochir. 2004;146(7):649–57.

    Article  PubMed  CAS  Google Scholar 

  17. Taylor CL, Dutton K, Rappard G, et al. Complications of preoperative embolization of cerebral arteriovenous malformations. J Neurosurg. 2004;100(5):810–2.

    Article  PubMed  Google Scholar 

  18. Vinuela F, Dion JE, Duckwiler G, et al. Combined endovascular embolization and surgery in the management of cerebral arteriovenous malformations: experience with 101 cases. J Neurosurg. 1991;75(6):856–64.

    Article  PubMed  CAS  Google Scholar 

  19. Wikholm G, Lundqvist C, Svendsen P. Embolization of cerebral arteriovenous malformations: part I—technique, morphology, and complications. Neurosurgery. 1996;39(3):448–57. Discussion 457–449.

    Article  PubMed  CAS  Google Scholar 

  20. Jayaraman MV, Marcellus ML, Do HM, et al. Hemorrhage rate in patients with Spetzler-Martin grades IV and V arteriovenous malformations: is treatment justified? Stroke. 2007;38(2):325–9.

    Article  PubMed  Google Scholar 

  21. van Beijnum J, van der Worp HB, Buis DR, et al. Treatment of brain arteriovenous malformations: a systematic review and meta-analysis. JAMA. 2011;306(18):2011–9.

    Article  PubMed  Google Scholar 

  22. Lv X, Wu Z, Jiang C, et al. Complication risk of endovascular embolization for cerebral arteriovenous malformation. Eur J Radiol. 2011;80(3):776–9.

    Article  PubMed  Google Scholar 

  23. Iwama T, Yoshimura K, Keller E, et al. Emergency craniotomy for intraparenchymal massive hematoma after embolization of supratentorial arteriovenous malformations. Neurosurgery. 2003;53(6):1251–8. Discussion 1258–1260.

    Article  PubMed  Google Scholar 

  24. Alexander MD, Cooke DL, Nelson J, et al. Association between venous angioarchitectural features of sporadic brain arteriovenous malformations and intracranial hemorrhage. AJNR Am J Neuroradiol. 2015;36(5):949–52.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  25. Gross BA, Du R. Natural history of cerebral arteriovenous malformations: a meta-analysis. J Neurosurg. 2013;118(2):437–43.

    Article  PubMed  Google Scholar 

  26. Kim H, Al-Shahi Salman R, McCulloch CE, Stapf C, Young WL, Coinvestigators M. Untreated brain arteriovenous malformation: patient-level meta-analysis of hemorrhage predictors. Neurology. 2014;83(7):590–7.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Mohr JP, Parides MK, Stapf C, et al. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet. 2014;383(9917):614–21.

    Article  CAS  PubMed  Google Scholar 

  28. Heit JJ, Faisal AG, Telischak NA, Choudhri O, Do HM. Headway Duo microcatheter for cerebral arteriovenous malformation embolization with n-BCA. J Neurointerv Surg. 2016;8(11):1181–5.

    Article  PubMed  Google Scholar 

  29. Katsaridis V, Papagiannaki C, Aimar E. Embolization of brain arteriovenous malformations for cure: because we could and because we should. AJNR Am J Neuroradiol. 2009;30(5):e67. Author reply e68.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Lv X, Wu Z, Jiang C, et al. Endovascular treatment accounts for a change in brain arteriovenous malformation natural history risk. Interv Neuroradiol. 2010;16(2):127–32.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  31. Natarajan SK, Born D, Ghodke B, Britz GW, Sekhar LN. Histopathological changes in brain arteriovenous malformations after embolization using Onyx or N-butyl cyanoacrylate. Laboratory investigation. J Neurosurg. 2009;111(1):105–13.

    Article  PubMed  CAS  Google Scholar 

  32. Panagiotopoulos V, Gizewski E, Asgari S, Regel J, Forsting M, Wanke I. Embolization of intracranial arteriovenous malformations with ethylene-vinyl alcohol copolymer (onyx). AJNR Am J Neuroradiol. 2009;30(1):99–106.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Stefani MA, Porter PJ, terBrugge KG, Montanera W, Willinsky RA, Wallace MC. Large and deep brain arteriovenous malformations are associated with risk of future hemorrhage. Stroke. 2002;33(5):1220–4.

    Article  PubMed  Google Scholar 

  34. van Rooij WJ, Sluzewski M, Beute GN. Brain AVM embolization with onyx. AJNR Am J Neuroradiol. 2007;28(1):172–7. Discussion 178.

    PubMed  PubMed Central  Google Scholar 

  35. Weber W, Kis B, Siekmann R, Kuehne D. Endovascular treatment of intracranial arteriovenous malformations with onyx: technical aspects. AJNR Am J Neuroradiol. 2007;28(2):371–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB. Management of vascular perforations that occur during neurointerventional procedures. AJNR Am J Neuroradiol. 1991;12(2):319–27.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Sinha PK, Neema PK, Rathod RC. Anesthesia and intracranial arteriovenous malformation. Neurol India. 2004;52(2):163–70.

    PubMed  Google Scholar 

  38. al-Rodhan NR, Sundt TM Jr, Piepgras DG, Nichols DA, Rufenacht D, Stevens LN. Occlusive hyperemia: a theory for the hemodynamic complications following resection of intracerebral arteriovenous malformations. J Neurosurg. 1993;78(2):167–75.

    Article  CAS  PubMed  Google Scholar 

  39. Miyasaka Y, Yada K, Ohwada T, et al. Hemorrhagic venous infarction after excision of an arteriovenous malformation: case report. Neurosurgery. 1991;29(2):265–8.

    Article  CAS  PubMed  Google Scholar 

  40. Nornes H, Grip A. Hemodynamic aspects of cerebral arteriovenous malformations. J Neurosurg. 1980;53(4):456–64.

    Article  PubMed  CAS  Google Scholar 

  41. Wilson CB, Hieshima G. Occlusive hyperemia: a new way to think about an old problem. J Neurosurg. 1993;78(2):165–6.

    Article  PubMed  CAS  Google Scholar 

  42. Barnett GH, Little JR, Ebrahim ZY, Jones SC, Friel HT. Cerebral circulation during arteriovenous malformation operation. Neurosurgery. 1987;20(6):836–42.

    Article  PubMed  CAS  Google Scholar 

  43. Day AL, Friedman WA, Sypert GW, Mickle JP. Successful treatment of the normal perfusion pressure breakthrough syndrome. Neurosurgery. 1982;11(5):625–30.

    Article  PubMed  CAS  Google Scholar 

  44. Leblanc R, Little JR. Hemodynamics of arteriovenous malformations. Clin Neurosurg. 1990;36:299–317.

    PubMed  CAS  Google Scholar 

  45. Nagao S, Ueta K, Mino S, et al. Monitoring of cortical blood flow during excision of arteriovenous malformation by thermal diffusion method. Surg Neurol. 1989;32(2):137–43.

    Article  PubMed  CAS  Google Scholar 

  46. Spetzler RF, Wilson CB, Weinstein P, Mehdorn M, Townsend J, Telles D. Normal perfusion pressure breakthrough theory. Clin Neurosurg. 1978;25:651–72.

    Article  PubMed  CAS  Google Scholar 

  47. Albert P. Personal experience in the treatment of 178 cases of arteriovenous malformations of the brain. Acta Neurochir. 1982;61(1–3):207–26.

    Article  PubMed  CAS  Google Scholar 

  48. Albert P, Salgado H, Polaina M, Trujillo F, Ponce de Leon A, Durand F. A study on the venous drainage of 150 cerebral arteriovenous malformations as related to haemorrhagic risks and size of the lesion. Acta Neurochir. 1990;103(1–2):30–4.

    Article  PubMed  CAS  Google Scholar 

  49. Alexander MD, Cooke DL, Hallam DK, Kim H, Hetts SW, Ghodke BV. Less can be more: targeted embolization of aneurysms associated with arteriovenous malformations unsuitable for surgical resection. Interv Neuroradiol. 2016;22(4):445–51.

    Article  PubMed Central  PubMed  Google Scholar 

  50. Bai J, Dou CW, Wang YJ, et al. Correlations of angio-architectural factors with cerebral arteriovenous malformation hemorrhage. Natl Med J China. 2012;92(31):2202–4.

    Google Scholar 

  51. Beltramello A, Ricciardi GK, Piovan E, et al. Operative classification of brain arteriovenous malformation. Part two: validation. Interv Neuroradiol. 2009;15(3):266–74.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  52. Cellerini M, Mangiafico S, Villa G, et al. Cerebral microarteriovenous malformations: diagnostic and therapeutic features in a series of patients. Am J Neuroradiol. 2002;23(6):945–52.

    PubMed  PubMed Central  Google Scholar 

  53. Dos Santos MLT, Demartini Z Jr, Matos LAD, et al. Angioarchitecture and clinical presentation of brain arteriovenous malformations. Arq Neuropsiquiatr. 2009;67(2 A):316–21.

    Article  Google Scholar 

  54. Duong DH, Young WL, Vang MC, et al. Feeding artery pressure and venous drainage pattern are primary determinants of hemorrhage from cerebral arteriovenous malformations. Stroke. 1998;29(6):1167–76.

    Article  PubMed  CAS  Google Scholar 

  55. Hsieh SC, Liu HM. Angioarchitecture in predicting the bleeding risk of cerebral arteriovenous malformations. Chin J Radiol. 1999;24(6):223–6.

    Google Scholar 

  56. Ji Y, Ding X, Wang ZG. Analysis of relevant factors of cerebral arteriovenous malformation with hemorrhage. Natl Med J China. 2012;92(35):2488–90.

    Google Scholar 

  57. Kader A, Young WL, Pile-Spellman J, et al. The influence of hemodynamic and anatomic factors on hemorrhage from cerebral arteriovenous malformations. Neurosurgery. 1994;34(5):801–8.

    PubMed  CAS  Google Scholar 

  58. Kandai S, Abdullah MS, Naing NN. Angioarchitecture of brain arteriovenous malformations and the risk of bleeding: an analysis of patients in northeastern Malaysia. Malays J Med Sci. 2010;17(1):44–8.

    PubMed Central  PubMed  Google Scholar 

  59. Khaw AV, Mohr JP, Sciacca RR, et al. Association of infratentorial brain arteriovenous malformations with hemorrhage at initial presentation. Stroke. 2004;35(3):660–3.

    Article  PubMed  CAS  Google Scholar 

  60. Kubalek R, Moghtaderi A, Klisch J, Berlis A, Quiske A, Schumacher M. Cerebral arteriovenous malformations: influence of angioarchitecture on bleeding risk. Acta Neurochir. 2003;145(12):1045–52.

    Article  PubMed  CAS  Google Scholar 

  61. Kubalek R, Yin L, Fronhöfer G, Schumacher M. Cerebral arterio-venous malformations: correlation between the angioarchitecture and the bleeding risk. Arteriovenöse malformationen des gehirns: Einflüsse der angioarchitektur auf das blutungsrisiko. 2001;11(2):97–104.

    Google Scholar 

  62. Langer DJ, Lasner TM, Hurst RW, Flamm ES, Zager EL, King JT Jr. Hypertension, small size, and deep venous drainage are associated with risk of hemorrhagic presentation of cerebral arteriovenous malformations. Neurosurgery. 1998;42(3):481–9.

    Article  PubMed  CAS  Google Scholar 

  63. Lv X, Wu Z, Jiang C, et al. Angioarchitectural characteristics of brain arteriovenous malformations with and without hemorrhage. World Neurosurg. 2011;76(1–2):95–9.

    Article  PubMed  Google Scholar 

  64. Marks MP, Lane B, Steinberg GK, Chang PJ. Hemorrhage in intracerebral arteriovenous malformations: angiographic determinants. Radiology. 1990;176(3):807–13.

    Article  PubMed  CAS  Google Scholar 

  65. Mast H, Young WL, Koennecke HC, et al. Risk of spontaneous haemorrhage after diagnosis of cerebral arteriovenous malformation. Lancet. 1997;350(9084):1065–8.

    Article  PubMed  CAS  Google Scholar 

  66. Miyasaka Y, Kurata A, Irikura K, Tanaka R, Fujii K. The influence of vascular pressure and angiographic characteristics on haemorrhage from arteriovenous malformations. Acta Neurochir. 2000;142(1):39–43.

    Article  PubMed  CAS  Google Scholar 

  67. Miyasaka Y, Tanaka R, Kurata A, et al. The factors influencing haematoma volume due to arteriovenous malformations. Acta Neurochir. 1999;141(4):385–8.

    Article  PubMed  CAS  Google Scholar 

  68. Miyasaka Y, Yada K, Ohwada T, Kitahara T, Kurata A, Irikura K. An analysis of the venous drainage system as a factor in hemorrhage from arteriovenous malformations. J Neurosurg. 1992;76(2):239–43.

    Article  PubMed  CAS  Google Scholar 

  69. Nataf F, Meder JF, Roux FX, et al. Angioarchitecture associated with haemorrhage in cerebral arteriovenous malformations: a prognostic statistical model. Neuroradiology. 1997;39(1):52–8.

    Article  PubMed  CAS  Google Scholar 

  70. Niu H, Cao Y, Wang X, et al. Relationships between hemorrhage, angioarchitectural factors and collagen of arteriovenous malformations. Neurosci Bull. 2012;28(5):595–05.

    Article  PubMed Central  PubMed  Google Scholar 

  71. Pasqualin A. Natural history of cerebral AVM. Epidemiologia e storia naturale delle MAV cerebrali. 2002;15(1):29–40.

    Google Scholar 

  72. Pasqualin A, Barone G, Cioffi F, Rosta L, Scienza R, Da Pian R. The relevance of anatomic and hemodynamic factors to a classification of cerebral arteriovenous malformations. Neurosurgery. 1991;28(3):370–9.

    Article  PubMed  CAS  Google Scholar 

  73. Pollock BE, Flickinger JC. A proposed radiosurgery-based grading system for arteriovenous malformations. J Neurosurg. 2002;96(1):79–85.

    Article  PubMed  Google Scholar 

  74. Pollock BE, Flickinger JC, Lunsford LD, Bissonette DJ, Kondziolka D. Factors that predict the bleeding risk of cerebral arteriovenous malformations. Stroke. 1996;27(1):1–6.

    Article  PubMed  CAS  Google Scholar 

  75. Spears J, TerBrugge KG, Moosavian M, et al. A discriminative prediction model of neurological outcome for patients undergoing surgery of brain arteriovenous malformations. Stroke. 2006;37(6):1457–64.

    Article  PubMed  Google Scholar 

  76. Stapf C, Mast H, Sciacca RR, et al. Predictors of hemorrhage in patients with untreated brain arteriovenous malformation. Neurology. 2006;66(9):1350–5.

    Article  PubMed  CAS  Google Scholar 

  77. Stefani MA, Porter PJ, TerBrugge KG, Montanera W, Willinsky RA, Wallace MC. Angioarchitectural factors present in brain arteriovenous malformations associated with hemorrhagic presentation. Stroke. 2002;33(4):920–4.

    Article  PubMed  Google Scholar 

  78. Stiver SI, Ogilvy CS. Micro-arteriovenous malformations: significant hemorrhage from small arteriovenous shunts. Neurosurgery. 2000;46(4):811–9.

    PubMed  CAS  Google Scholar 

  79. Vinuela F, Nombela L, Roach MR, Fox AJ, Pelz DM. Stenotic and occlusive disease of the venous drainage system of deep brain AVM's. J Neurosurg. 1985;63(2):180–4.

    Article  PubMed  CAS  Google Scholar 

  80. Yamada S, Takagi Y, Nozaki K, Kikuta KI, Hashimoto N. Risk factors for subsequent hemorrhage in patients with cerebral arteriovenous malformations. J Neurosurg. 2007;107(5):965–72.

    Article  PubMed  Google Scholar 

  81. Inci S, Ozcan OE, Benli K, Saatci I. Microsurgical removal of a free segment of microcatheter in the anterior circulation as a complication of embolization. Surg Neurol. 1996;46(6):562–6. Discussion 566–567.

    Article  PubMed  CAS  Google Scholar 

  82. Kallmes DF, McGraw JK, Evans AJ, et al. Thrombogenicity of hydrophilic and nonhydrophilic microcatheters and guiding catheters. AJNR Am J Neuroradiol. 1997;18(7):1243–51.

    PubMed  PubMed Central  CAS  Google Scholar 

  83. Partington CR, Graves VB, Rufenacht DA, et al. Biocompatibility of 1-French polyethylene catheters used in interventional neuroradiology procedures: a study with rats and dogs. AJNR Am J Neuroradiol. 1990;11(5):881–5.

    PubMed  PubMed Central  CAS  Google Scholar 

  84. Smith TP, Graves VB, Halbach VV, et al. Microcatheter retrieval device for intravascular foreign body removal. AJNR Am J Neuroradiol. 1993;14(4):809–11.

    PubMed  PubMed Central  CAS  Google Scholar 

  85. Altschul D, Paramasivam S, Ortega-Gutierrez S, Fifi JT, Berenstein A. Safety and efficacy using a detachable tip microcatheter in the embolization of pediatric arteriovenous malformations. Childs Nerv Syst. 2014;30(6):1099–107.

    Article  PubMed  Google Scholar 

  86. Paramasivam S, Altschul D, Ortega-Gutiarrez S, Fifi J, Berenstein A. N-butyl cyanoacrylate embolization using a detachable tip microcatheter: initial experience. J Neurointerv Surg. 2015;7(6):458–61.

    Article  PubMed  Google Scholar 

  87. Berthelsen B, Lofgren J, Svendsen P. Embolization of cerebral arteriovenous malformations with bucrylate. Experience in a first series of 29 patients. Acta Radiol. 1990;31(1):13–21.

    Article  PubMed  CAS  Google Scholar 

  88. Biondi A, Le Jean L, Capelle L, Duffau H, Marsault C. Fatal hemorrhagic complication following endovascular treatment of a cerebral arteriovenous malformation. Case report and review of the literature. J Neuroradiol. 2006;33(2):96–104.

    Article  PubMed  CAS  Google Scholar 

  89. Goto K, Uda K, Ogata N. Embolization of cerebral arteriovenous malformations (AVMs)—material selection, improved technique, and tactics in the initial therapy of cerebral AVMs. Neurol Med Chir (Tokyo). 1998;38(Suppl):193–9.

    Article  Google Scholar 

  90. Inagawa S, Isoda H, Kougo H, Isogais S, Sakahara H. In-vitro simulation of NBCA embolization for arteriovenous malformation. Interv Neuroradiol. 2003;9(4):351–8.

    Article  CAS  PubMed  Google Scholar 

  91. Pile-Spellman J, Young WL, Joshi S, et al. Adenosine-induced cardiac pause for endovascular embolization of cerebral arteriovenous malformations: technical case report. Neurosurgery. 1999;44(4):881–6. Discussion 886–887.

    Article  CAS  PubMed  Google Scholar 

  92. Suh DC, Kim JH, Lee MS, et al. Penetration difference of n-butyl2-cyanoacrylate into the nidus in the embolisation of brain arteriovenous malformation. Interv Neuroradiol. 1998;4(1):63–74.

    Article  CAS  PubMed  Google Scholar 

  93. Tamatani S, Ito Y, Koike T, et al. Efficacy of diluted NBCA mixture for embolization of arteriovenous malformations. Interv Neuroradiol. 1999;5(Suppl 1):161–5.

    Article  PubMed  Google Scholar 

  94. Tamatani S, Koike T, Ito Y, Tanaka R. Embolization of arteriovenous malformation with diluted mixture of NBCA. Interv Neuroradiol. 2000;6(Suppl 1):187–90.

    Article  PubMed  Google Scholar 

  95. Goto K, Uda K, Ogata N. Improved technique for liquid embolization of cerebral arteriovenous malformation: catheter-tip position and flow control. J Clin Neurosci. 1998;5(Suppl):91–4.

    Article  PubMed  Google Scholar 

  96. Deruty R, Pelissou-Guyotat I, Mottolese C, et al. [Therapeutic risk in multidisciplinary approach of cerebral arteriovenous malformations]. Neurochirurgie. 1996;42(1):35–43.

    Google Scholar 

  97. Fahed R, Clarencon F, Sourour NA, et al. Rescue N-butyl-2 cyanoacrylate embolectomy using a Solitaire FR device after venous glue migration during arteriovenous malformation embolization: technical note. J Neurosurg. 2016;125(1):173–6.

    Article  PubMed  Google Scholar 

  98. Hademenos GJ, Massoud TF. Risk of intracranial arteriovenous malformation rupture due to venous drainage impairment a theoretical analysis. Stroke. 1996;27(6):1072–83.

    Article  PubMed  CAS  Google Scholar 

  99. Hademenos GJ, Massoud TF. An electrical network model of intracranial arteriovenous malformations: analysis of variations in hemodynamic and biophysical parameters. Neurol Res. 1996;18(6):575–89.

    Article  PubMed  CAS  Google Scholar 

  100. Hademenos GJ, Massoud TF, Viñuela F. A biomathematical model of intracranial arteriovenous malformations based on electrical network analysis: theory and hemodynamics. Neurosurgery. 1996;38(5):1005–15.

    Article  CAS  PubMed  Google Scholar 

  101. Miyasaka Y, Kurata A, Tokiwa K, Tanaka R, Yada K, Ohwada T. Draining vein pressure increases and hemorrhage in patients with arteriovenous malformation. Stroke. 1994;25(2):504–7.

    Article  CAS  PubMed  Google Scholar 

  102. Norbash AM, Marks MP, Lane B. Correlation of pressure measurements with angiographic characteristics predisposing to hemorrhage and steal in cerebral arteriovenous malformations. Am J Neuroradiol. 1994;15(5):809–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  103. Young WL, Kader A, Pile-Spellman J, et al. Arteriovenous malformation draining vein physiology and determinants of transnidal pressure gradients. Neurosurgery. 1994;35(3):389–96.

    Article  CAS  PubMed  Google Scholar 

  104. Willinsky R, Lasjaunias P, Terbrugge K, Pruvost P. Brain arteriovenous malformations: analysis of the angio-architecture in relationship to hemorrhage (based on 152 patients explored and/or treated at the hospital de Bicetre between 1981 and 1986). J Neuroradiol. 1988;15(3):225–37. MALFORMATIONS ARTERIO-VEINEUSES CEREBRALES. ANALYSE DE L'ANGIO-ARCHITECTURE CHEZ DES PATIENTS AYANT PRESENTE UN ACCIDENT HEMORRAGIQUE. REVUE DE 152 MALADES EXPLORES OU TRAITES A L'HOPITAL DE BICETRE ENTRE 1981 ET 1986.

    CAS  PubMed  Google Scholar 

  105. Geibprasert S, Pongpech S, Jiarakongmun P, Shroff MM, Armstrong DC, Krings T. Radiologic assessment of brain arteriovenous malformations: what clinicians need to know. Radiographics. 2010;30(2):483–501.

    Article  PubMed  Google Scholar 

  106. Lasjaunias P, Manelfe C, Terbrugge K, Lopez Ibor L. Endovascular treatment of cerebral arteriovenous malformations. Neurosurg Rev. 1986;9(4):265–75.

    Article  CAS  PubMed  Google Scholar 

  107. Mansmann U, Meisel J, Brock M, Rodesch G, Alvarez H, Lasjaunias P. Factors associated with intracranial hemorrhage in cases of cerebral arteriovenous malformation. Neurosurgery. 2000;46(2):272–81.

    Article  CAS  PubMed  Google Scholar 

  108. Turjman F, Massoud TF, Sayre JW, Vinuela F, Guglielmi G, Duckwiler G. Epilepsy associated with cerebral arteriovenous malformations: a multivariate analysis of angioarchitectural characteristics. Am J Neuroradiol. 1995;16(2):345–50.

    CAS  PubMed  PubMed Central  Google Scholar 

  109. Batjer HH, Devous MD Sr. The use of acetazolamide-enhanced regional cerebral blood flow measurement to predict risk to arteriovenous malformation patients. Neurosurgery. 1992;31(2):213–7. Discussion 217–218.

    Article  CAS  PubMed  Google Scholar 

  110. Hassler W, Steinmetz H. Cerebral hemodynamics in angioma patients: an intraoperative study. J Neurosurg. 1987;67(6):822–31.

    Article  PubMed  CAS  Google Scholar 

  111. Merland JJ, Rufenacht D, Laurent A, Guimaraens L. Endovascular treatment with isobutyl cyano acrylate in patients with arteriovenous malformation of the brain. Indications, results and complications. Acta Radiolog Suppl. 1986;369:621–2.

    CAS  Google Scholar 

  112. Morgan MK, Sundt TM Jr. The case against staged operative resection of cerebral arteriovenous malformations. Neurosurgery. 1989;25(3):429–35. Discussion 435–426.

    Article  PubMed  CAS  Google Scholar 

  113. Vinters HV, Lundie MJ, Kaufmann JC. Long-term pathological follow-up of cerebral arteriovenous malformations treated by embolization with bucrylate. N Engl J Med. 1986;314(8):477–83.

    Article  PubMed  CAS  Google Scholar 

  114. Young WL, Kader A, Prohovnik I, et al. Pressure autoregulation is intact after arteriovenous malformation resection. Neurosurgery. 1993;32(4):491–6. Discussion 496–497.

    Article  PubMed  CAS  Google Scholar 

  115. Young WL, Prohovnik I, Ornstein E, et al. The effect of arteriovenous malformation resection on cerebrovascular reactivity to carbon dioxide. Neurosurgery. 1990;27(2):257–66. Discussion 266–257.

    Article  PubMed  CAS  Google Scholar 

  116. Alexander MJ, Tolbert ME. Targeting cerebral arteriovenous malformations for minimally invasive therapy. Neurosurgery. 2006;59(5 Suppl 3):S178–83. Discussion S173–113.

    PubMed  Google Scholar 

  117. Krings T, Hans FJ, Geibprasert S, Terbrugge K. Partial “targeted” embolisation of brain arteriovenous malformations. Eur Radiol. 2010;20(11):2723–31.

    Article  PubMed Central  PubMed  Google Scholar 

  118. Le Feuvre D, Taylor A. Target embolization of AVMs: identification of sites and results of treatment. Interv Neuroradiol. 2007;13(4):389–94.

    Article  PubMed  Google Scholar 

  119. Settecase F, Hetts SW, Nicholson AD, et al. Superselective intra-arterial ethanol sclerotherapy of feeding artery and nidal aneurysms in ruptured cerebral arteriovenous malformations. AJNR Am J Neuroradiol. 2016;37(4):692–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  120. Heidenreich JO, Hartlieb S, Stendel R, et al. Bleeding complications after endovascular therapy of cerebral arteriovenous malformations. AJNR Am J Neuroradiol. 2006;27(2):313–6.

    PubMed  PubMed Central  CAS  Google Scholar 

  121. Morgan MK, Johnston IH, Hallinan JM, Weber NC. Complications of surgery for arteriovenous malformations of the brain. J Neurosurg. 1993;78(2):176–82.

    Article  PubMed  CAS  Google Scholar 

  122. Young WL, Pile-Spellman J. Anesthetic considerations for interventional neuroradiology. Anesthesiology. 1994;80(2):427–56.

    Article  PubMed  CAS  Google Scholar 

  123. Mourier KL, Bellec C, Lot G, et al. Pyogenic parenchymatous and nidus infection after embolization of an arteriovenous malformation. An unusual complication. Case report. Acta Neurochir. 1993;122(1–2):130–3.

    Article  PubMed  CAS  Google Scholar 

  124. Sharma A, Jagetia A, Loomba P, Singh D, Tandon M. Delayed brain abscess after embolization of arterio-venous malformation: report of two cases and review of literature. Neurol India. 2011;59(4):620–3.

    Article  PubMed  Google Scholar 

  125. Ito M, Sonokawa T, Mishina H, Iizuka Y, Sato K. Disrupted and migrated microcatheter in the vertebrobasilar artery system in endovascular embolization of cerebellar AVM: failure of endovascular and microneurosurgical retrieval. J Clin Neurosci. 1998;5(Suppl):49–53.

    Article  PubMed  Google Scholar 

  126. Bingol H, Sirin G, Akay HT, Iyem H, Demirkilic U, Tatar H. Management of a retained catheter in an arteriovenous malformation. Case report. J Neurosurg. 2007;106(3):481–3.

    Article  PubMed  Google Scholar 

  127. Li T, Duan C, Wang Q, et al. Endovascular embolization of cerebral arteriovenous malformation. Zhonghua Yi Xue Za Zhi. 2002;82(10):654–6.

    PubMed  Google Scholar 

  128. Li TL, Fang B, He XY, et al. Complication analysis of 469 brain arteriovenous malformations treated with N-butyl cyanoacrylate. Interv Neuroradiol. 2005;11(2):141–8.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  129. Hetts S, Werne A, Hieshima GB. …and do no harm. AJNR Am J Neuroradiol. 1995;16(1):1–5.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. UCSF Department of Radiology and Biomedical Imaging, 505 Parnassus Ave, San Francisco, CA, 94143-0628, USA

    Matthew D. Alexander M.D., Daniel L. Cooke M.D. & Steven W. Hetts M.D.

Authors
  1. Matthew D. Alexander M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daniel L. Cooke M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Steven W. Hetts M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Steven W. Hetts M.D. .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Westchester Medical Center/NY Medical College, Valhalla, New York, USA

    Chirag D. Gandhi

  2. Department of Neurological Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    Charles J. Prestigiacomo

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Alexander, M.D., Cooke, D.L., Hetts, S.W. (2018). Treatment of Arteriovenous Malformations with Cyanoacrylate. In: Gandhi, C., Prestigiacomo, C. (eds) Cerebrovascular and Endovascular Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-65206-1_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-65206-1_28

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-65204-7

  • Online ISBN: 978-3-319-65206-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation