Abstract
Perforation remains a potential lethal complication of peptic ulcer disease. The surgeon should have a high degree of suspicion for perforated ulcer when a patient presents with sudden onset of severe abdominal pain, nausea, vomiting, fever and peritonitis. This can rapidly progress to septic shock if the diagnosis and treatment are delayed. The goal of laparoscopic peptic ulcer repair is no different than that of the open repair, namely, source control through sealing of the perforation and peritoneal irrigation. This chapter describes laparoscopic repair of perforated ulcer including primary repair and Graham patch technique focusing on operating room set-up, instrumentation, operative steps, contraindications and post-operative care.
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Key References
Muller MK, et al. Perforated peptic ulcer repair: factors predicting conversion in laparoscopy and postoperative septic complications. World J Surg. 2016;40(9):2186–93.
Stewart B, et al. Global disease burden of conditions requiring emergency surgery. Br J Surg. 2014;101(1):e9–22.
Soreide K, et al. Perforated peptic ulcer. Lancet. 2015;386(10000):1288–98.
Bertleff MJ, Lange JF. Laparoscopic correction of perforated peptic ulcer: first choice? A review of literature. Surg Endosc. 2010;24(6):1231–9.
Wang AY, Peura DA. The prevalence and incidence of Helicobacter pylori-associated peptic ulcer disease and upper gastrointestinal bleeding throughout the world. Gastrointest Endosc Clin N Am. 2011;21(4):613–35.
Lau JY, et al. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion. 2011;84(2):102–13.
Wang YR, Richter JE, Dempsey DT. Trends and outcomes of hospitalizations for peptic ulcer disease in the United States, 1993 to 2006. Ann Surg. 2010;251(1):51–8.
Thorsen K, Soreide JA, Soreide K. What is the best predictor of mortality in perforated peptic ulcer disease? A population-based, multivariable regression analysis including three clinical scoring systems. J Gastrointest Surg. 2014;18(7):1261–8.
Salama NR, Hartung ML, Muller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol. 2013;11(6):385–99.
Svanes C, et al. Smoking and ulcer perforation. Gut. 1997;41(2):177–80.
Cid T. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2013;18(Suppl 1):12–7. doi:10.1111/hel.12076.
Dakubo JC, Naaeder SB, Clegg-Lamptey JN. Gastro-duodenal peptic ulcer perforation. East Afr Med J. 2009;86(3):100–9.
Soreide K, Thorsen K, Soreide JA. Predicting outcomes in patients with perforated gastroduodenal ulcers: artificial neural network modelling indicates a highly complex disease. Eur J Trauma Emerg Surg. 2015;41(1):91–8.
Hirschowitz BI, Simmons J, Mohnen J. Clinical outcome using lansoprazole in acid hypersecretors with and without Zollinger-Ellison syndrome: a 13-year prospective study. Clin Gastroenterol Hepatol. 2005;3(1):39–48.
Kumar A, et al. The etiology of pneumoperitoneum in the 21st century. J Trauma Acute Care Surg. 2012;73(3):542–8.
Thorsen K, et al. Trends in diagnosis and surgical management of patients with perforated peptic ulcer. J Gastrointest Surg. 2011;15(8):1329–35.
Ghekiere O, et al. Value of computed tomography in the diagnosis of the cause of nontraumatic gastrointestinal tract perforation. J Comput Assist Tomogr. 2007;31(2):169–76.
Furukawa A, et al. Gastrointestinal tract perforation: CT diagnosis of presence, site, and cause. Abdom Imaging. 2005;30(5):524–34.
Taylor H. Perforated peptic ulcer; treated without operation. Lancet. 1946;2(6422):441–4.
Crofts TJ, et al. A randomized trial of nonoperative treatment for perforated peptic ulcer. N Engl J Med. 1989;320(15):970–3.
Sanabria A, Villegas MI, Morales Uribe CH. Laparoscopic repair for perforated peptic ulcer disease. Cochrane Database Syst Rev. 2013;2:CD004778.
Siu WT, et al. Laparoscopic repair for perforated peptic ulcer: a randomized controlled trial. Ann Surg. 2002;235(3):313–9.
Byrge N, et al. Laparoscopic versus open repair of perforated gastroduodenal ulcer: a National Surgical Quality Improvement Program analysis. Am J Surg. 2013;206(6):957–62. discussion 962-3
Lunevicius R, Morkevicius M. Management strategies, early results, benefits, and risk factors of laparoscopic repair of perforated peptic ulcer. World J Surg. 2005;29(10):1299–310.
Lunevicius R, Morkevicius M. Systematic review comparing laparoscopic and open repair for perforated peptic ulcer. Br J Surg. 2005;92(10):1195–207.
Lagoo SA, Pappas TN. Laparoscopic repair for perforated peptic ulcer. Ann Surg. 2002;235(3):320–1.
Lagoo S, McMahon RL, kakihara M, Pappas T, Eubanks S. The sixth decision regarding perforated duodenal ulcer. JSLS. 2002;6(4):359–68.
Pappas TN. Laparoscopic repair of perforated ulcer and Vagotomy. In: Pappas TN, Chekan EG, Eubanks S, editors. Atlas of laparoscopic surgery. Philadelphia: McGraw-Hill Professional Publishing; 1999.
Lunca Y. Laparoscopic repair of perforated peptic ulcer. Jurnalul de Chirurgie. 2007;3(2):1584–9341.
Mancini GJ, Mancini ML. Peptic ulcer surgery. In: Vernon AH, Ashley SW, editors. Atlas of minimally invasive surgical techniques. St Louis: Elsevier Saunders; 2012.
Walsh CJ, Khoo DE, Motson RW. Laparoscopic repair of perforated peptic ulcer. Br J Surg. 1993;80(1):127.
Michelet I, Agresta F. Perforated peptic ulcer: laparoscopic approach. Eur J Surg. 2000;166(5):405–8.
Nathanson LK, Easter DW, Cuschieri A. Laparoscopic repair/peritoneal toilet of perforated duodenal ulcer. Surg Endosc. 1990;4(4):232–3.
So JB, et al. Comparison between laparoscopic and conventional omental patch repair for perforated duodenal ulcer. Surg Endosc. 1996;10(11):1060–3.
Khoursheed M, et al. Laparoscopic closure of perforated duodenal ulcer. Surg Endosc. 2000;14(1):56–8.
Robertson GS, Wemyss-Holden SA, Maddern GJ. Laparoscopic repair of perforated peptic ulcers. The role of laparoscopy in generalised peritonitis. Ann R Coll Surg Engl. 2000;82(1):6–10.
Boshnaq TA, Martini I, Doughan S. Utilisation of the falciform ligament pedicle flap as an alternative approach for the repair of a perforated gastric ulcer. BMJ Case Rep. 2016;10 doi:10.1136/bcr-2015-213025.
Munro WS, Bajwa F, Menzies D. Laparoscopic repair of perforated duodenal ulcers with a falciform ligament patch. Ann R Coll Surg Engl. 1996;78(4):390–1.
Costalat G, Alquier Y. Combined laparoscopic and endoscopic treatment of perforated gastroduodenal ulcer using the ligamentum teres hepatis (LTH). Surg Endosc. 1995;9(6):677–9. discussion 680.
Lunevicius R, Morkevicius M. Comparison of laparoscopic versus open repair for perforated duodenal ulcers. Surg Endosc. 2005;19(12):1565–71.
Halkic N, Pescatore P, Gillet M. Laparoscopic-endoscopic management of perforated pyloroduodenal ulcer. Endoscopy. 1999;31(9):S64–5.
Matsuda M, et al. Laparoscopic omental patch repair for perforated peptic ulcer. Ann Surg. 1995;221(3):236–40.
Seelig MH, et al. Comparison between open and laparoscopic technique in the management of perforated gastroduodenal ulcers. J Clin Gastroenterol. 2003;37(3):226–9.
Pai D, et al. Role of abdominal drains in perforated duodenal ulcer patients: a prospective controlled study. Aust N Z J Surg. 1999;69(3):210–3.
Lee FY, et al. Predicting mortality and morbidity of patients operated on for perforated peptic ulcers. Arch Surg. 2001;136(1):90–4.
Thompson AR, et al. Laparoscopic plication of perforated ulcer: results of a selective approach. South Med J. 1995;88(2):185–9.
Moller MH, et al. Preoperative prognostic factors for mortality in peptic ulcer perforation: a systematic review. Scand J Gastroenterol. 2010;45(7–8):785–805.
Urbano D, et al. Alternative laparoscopic management of perforated peptic ulcers. Surg Endosc. 1994;8(10):1208–11.
Abd Ellatif ME, et al. Laparoscopic repair of perforated peptic ulcer: patch versus simple closure. Int J Surg. 2013;11(9):948–51.
Wong CS, et al. Eradication of Helicobacter pylori for prevention of ulcer recurrence after simple closure of perforated peptic ulcer: a meta-analysis of randomized controlled trials. J Surg Res. 2013;182(2):219–26.
Yuan Y, et al. Optimum duration of regimens for Helicobacter pylori eradication. Cochrane Database Syst Rev. 2013;12:CD008337.
Kumar P, Khan HM, Hasanrabba S. Treatment of perforated giant gastric ulcer in an emergency setting. World J Gastrointest Surg. 2014;6(1):5–8.
Suggested Reading
Bertleff MJ, Lange JF. Laparoscopic correction of perforated peptic ulcer: first choice? A review of literature. Surg Endosc. 2010;24:1231–9.
Lunevicius R, Morkevicius M. Management strategies, early results, benefits, and risk factors of laparoscopic repair of perforated peptic ulcer. World J Surg. 2005;29:1299–310. doi:10.1007/s00268-005-7705-4.
Muller M, Wrann S, Widmer J, Klasen J, Weber M, Hahnloser D. Perforated peptic ulcer repair: factors predicting conversion in laparoscopy and postoperative septic complications. World J Surg. 2016;40(9):2186–93.
Sanabria A, Villegas MI, Morales Uribe CH. Laparoscopic repair for perforated peptic ulcer disease. Cochrane Database Syst Rev. 2013;2:CD004778.
Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, Søreide JA. Perforated peptic ulcer. Lancet. 2015;386:1288–98.
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Al Mahroos, M.H., Feldman, L.S. (2018). Laparoscopic Management of Perforated Ulcers. In: Khwaja, K., Diaz, J. (eds) Minimally Invasive Acute Care Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-64723-4_8
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DOI: https://doi.org/10.1007/978-3-319-64723-4_8
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