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Circadian Control of Mitochondrial Dynamics and Its Implication in Aging

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Circadian Rhythms and Their Impact on Aging

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 7))

Abstract

The circadian clock promotes metabolic efficiency by pre-programmed regulation of metabolic pathways in anticipation of the upcoming feeding/fasting cycle. Recent studies have suggested that the master circadian regulators Bmal1/Clock play an important role in controlling mitochondrial function, including oxidative metabolism and mitochondrial dynamics . The latter includes mitochondrial fusion, fission, and selective autophagy (mitophagy ) that follows fission. These processes not only allow mitochondria to undergo architectural/organizational changes in response to different nutrient conditions but also ensure quality control by removing damaged components through mitophagy . Results from mouse genetic models indicate that Bmal1-dependent regulation of fission and mitophagy genes reduces oxidative stress and maintains metabolic flexibility in the liver. In addition, aha-1, a C. elegans Bmal1 homologue, is required for orderly organizations of muscle mitochondria. Interestingly, Baml1 whole body knockout mice develop premature aging phenotypes, while AHA-1 over-expression increases lifespan in worms. Given that mitochondrial dysfunction appears to be a common feature associated with aging, obesity , and related metabolic diseases , these findings implicate an evolutionarily conserved regulatory mechanism that links mitochondrial fidelity to lifespan and/or healthspan.

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Acknowledgements

D. Jacobi and F. Atger are supported by the INSERM ATIP-Avenir program and by a grant from the Genavie foundation. C-.H. Lee is supported by American Diabetes Association grant 1-14-BS-122, American Heart Association grant 16GRNT31460005, and NIH grant R01DK113791.

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  1. Division of Biological Sciences, Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA

    David Jacobi & Chih-Hao Lee

  2. L’institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, France

    David Jacobi & Florian Atger

  3. L’institut du thorax, CHU Nantes, Nantes, France

    David Jacobi

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  2. Florian Atger
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Correspondence to Chih-Hao Lee .

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  1. Tulane Center for Aging, Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    S. Michal Jazwinski

  2. Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    Victoria P Belancio

  3. Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    Steven M Hill

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Jacobi, D., Atger, F., Lee, CH. (2017). Circadian Control of Mitochondrial Dynamics and Its Implication in Aging. In: Jazwinski, S., Belancio, V., Hill, S. (eds) Circadian Rhythms and Their Impact on Aging. Healthy Ageing and Longevity, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-64543-8_7

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