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Aging and the Circadian Control of the Gastrointestinal System: From the Brain to the Gut Microbiome (and Back)

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Circadian Rhythms and Their Impact on Aging

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 7))

Abstract

The effect of aging on circadian clocks within the gastrointestinal system and the role played by melatonin and circadian clocks in the process of gastrointestinal aging is reviewed. Although we know quite a lot about the physiological and molecular mechanisms of circadian clocks in mammals, we know very little about the mechanisms of food-entrainable rhythmicity. The role played by the pineal hormone melatonin has been posited as a key to understanding aging and clock function, but the evidence is incomplete. Finally, new data about aging and circadian control of the intestinal microbiome is placed in the context of the circadian system as a whole.

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Acknowledgements

The Cassone lab is funded by NIH R01 AG045833.

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Authors and Affiliations

  1. Department of Biology, University of Kentucky, Lexington, KY, 40506, USA

    Vincent M. Cassone, Jiffin K. Paulose & Clifford E. Harpole

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  1. Vincent M. Cassone
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  2. Jiffin K. Paulose
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  3. Clifford E. Harpole
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Correspondence to Vincent M. Cassone .

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Editors and Affiliations

  1. Tulane Center for Aging, Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    S. Michal Jazwinski

  2. Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    Victoria P Belancio

  3. Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    Steven M Hill

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Cassone, V.M., Paulose, J.K., Harpole, C.E. (2017). Aging and the Circadian Control of the Gastrointestinal System: From the Brain to the Gut Microbiome (and Back). In: Jazwinski, S., Belancio, V., Hill, S. (eds) Circadian Rhythms and Their Impact on Aging. Healthy Ageing and Longevity, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-64543-8_4

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