Abstract
An 80-year-old man presents to the ED via ambulance from a local nursing home with confused speech (episodic/waxing and waning), fever, and chills for 1 day. Per nursing home report, he had been feeling unwell for the last 2 days. Paperwork reveals he has had a nonproductive cough and sore throat, and several other residents at the facility had been ill with similar symptoms. He reports a frontal headache which is more painful than his associated myalgias and was given Tylenol. There is no report of a fall or trauma. His baseline mental status is alert and oriented with the ability to converse and perform many activities of daily living. He is unable to manage his finances and medications. His baseline heart rate is 70–90s; his blood pressure range is in the 120–130s/60–90s. He has lived at the nursing home for the past year since diagnosed with mild cognitive impairment. He previously lived alone and his wife died 2 years ago. There is no family in the region. On arrival to the ED, his initial vital signs are T 103 F, BP 94/49, R 24, HR 108, and O2 sats 94% on room air with a GCS 13.
This is a preview of subscription content, log in via an institution.
References
Auriel E, Regev K, Korczyn A. Non-steroidal anti-inflammatory drugs exposure and the central nervous system. Handb Clin Neurol. 2014;119:577–84.
Attia JMD, Hatala R, Cook DJ, Wong JG. Does this adult patient have acute meningitis? JAMA. 1999;282(2):175–81.
Bamberger D. Diagnosis, initial management, and prevention of meningitis. Am Fam Physician. 2000;82(12):1491–8.
Brouwer M, Tunkel A, McKhann G II, Van de Beek D. Brain abscess. N Engl J Med. 2014;371:447–56.
Brouwer MC, Mcintyre P, Prasad K, Van de Beek D. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004405.
Bruner EKMD, Coop CCMD, White KMMD. Trimethoprim-sulfamethoxazole induced aseptic meningitis—not just another sulfa allergy. Ann Allergy Asthma Immunol. 2014;113(5):520–6.
Cherubin CE, Eng RH, Norrby R, Modai J, Humbert G, Overturf G. Penetration of newer cephalosporins into cerebrospinal fluid. Rev Infect Dis. 1989;11(4):526–48.
De Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N Engl J Med. 2002;347(20):1549–56.
De Vlieghere FC, Peetermans WE, Vermylen J. Aseptic granulocytic meningitis following treatment with intravenous immunoglobulin. Clin Infect Dis. 1994;18(6):1008–10.
Durand LM, Calderwood SB, Weber DJ, Miller SI, Southwick FS, Caviness VS Jr, Swartz MN. Acute bacterial meningitis in adults—a review of 493 episodes. N Engl J Med. 1993;328(1):21–8.
Fitch MT, van de Beek D. Emergency diagnosis and treatment of adult meningitis. Lancet Infect Dis. 2007;7(3):191–200.
Hankins DG, Rosekrans JA. Overview, prevention, and treatment of rabies. Mayo Clin Proc. 2004;79(5):671–6.
Leibovici L, Gafter-Gvili M, Paul M, Almanasreh N, Tacconelli E, Andreassen S, Nielsen AD, Frank U, Cauda R. Relative tachycardia in patients with sepsis: an independent risk factor for mortality. Q J Med. 2007;100(10):629–34.
Miner J, Heegaard W, Mapes A, Biros M. Presentation time to antibiotics, and mortality of patients with bacterial meningitis at an urban county medical center. J Emerg Med. 2001;21(4):387–92.
Michael B, Menezes BF, Cunniffe J, Miller A, Kneen R, Francis G, Beeching NJ, Solomon T. Effect of delayed lumbar punctures on the diagnosis of acute bacterial meningitis in adults. Emerg Med J. 2010;27(6):433–8.
Mung'Ala-Odera V, Snow RW, Newton CR. The burden of the neurocognitive impairment associated with plasmodium falciparum malaria in sub-Saharan Africa. Am J Trop Med Hygiene. 2004;71(2 suppl):64–70.
Rady MY, Smithline HA, Blake H, Nowak R, Rivers E. A comparison of the shock index and conventional vital signs to identify acute, critical illness in the ED. Ann Emerg Med. 1994;24(4):685–90.
Rasmussen HH, Sorensen HT, Moller-Petersen J, Mortensen FV, Nielsen B. Bacterial meningitis in elderly patients: clinical picture and course. Age Ageing. 1992;21(3):216–20.
Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801–10.
Thomas KE, Hasbun TR, Jekel J, Quagliarello VJ. The diagnostic accuracy of Kernig’s sign, Brudzinski’s sign, and nuchal rigidity in adults with suspected meningitis. Clin Infect Dis. 2002;35(1):46–52.
Tunkel AR, Hartman BJ, Kaplan SL, Kaufman KA, Roos KL, Scheld WM, Whitley RJ. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39(9):1267–84.
Uchihara T, Tsukagoshi H. Jolt accentuation of headache: the most sensitive sign of CSF pleocytosis. Headache. 1991;31(3):167–71.
Van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351(18):1849–59.
Wira C, Francis MW, Bhat S, et al. The shock index as a predictor of vasopressor use in ED patients with severe sepsis. WJEM. 2014;15(1):60–6.
World Health Organization. Guidelines for treatment of Malaria. 2015 [cited 2016 Apr 29]. 3rd ed. Geneva. http://apps.who.int/iris/bitstream/10665/162441/1/9789241549127_eng.pdf.
Centers for Disease Control and Prevention. Control and Prevention of Meningococcal Disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Atlanta, GA. 1997 [cited 2016 Apr 29]. http://www.cdc.gov/mmwr/preview/mmwrhtml/00046263.htm.
Centers for Disease Control and Prevention. Rabies in the U.S. Atlanta, GA. 2011 [cited 2016 Apr 29]. http://www.cdc.gov/rabies/location/index.html.
Acknowledgment
No financial/commercial conflicts to disclose
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this chapter
Cite this chapter
Felton, O., Wira, C.R. (2018). Infections of the Central Nervous System. In: Ganti, L., Goldstein, J. (eds) Neurologic Emergencies. Springer, Cham. https://doi.org/10.1007/978-3-319-64523-0_13
Download citation
DOI: https://doi.org/10.1007/978-3-319-64523-0_13
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-64521-6
Online ISBN: 978-3-319-64523-0
eBook Packages: MedicineMedicine (R0)