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Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control pp 135–154Cite as

Mycobacterium tuberculosis Complex Members Adapted to Wild and Domestic Animals

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1019))

Abstract

The Mycobacterium tuberculosis complex (MTBC) is composed of several highly genetically related species that can be broadly classified into those that are human-host adapted and those that possess the ability to propagate and transmit in a variety of wild and domesticated animals. Since the initial description of the bovine tubercle bacillus, now known as Mycobacterium bovis, by Theobald Smith in the late 1800’s, isolates originating from a wide range of animal hosts have been identified and characterized as M. microti, M. pinnipedii, the Dassie bacillus, M. mungi, M. caprae, M. orygis and M. suricattae. This chapter outlines the events resulting in the identification of each of these animal-adapted species, their close genetic relationships, and how genome-based phylogenetic analyses of species-specific variation amongst MTBC members is beginning to unravel the events that resulted in the evolution of the MTBC and the observed host tropism between the human- and animal-adapted member species.

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Authors and Affiliations

  1. UCD School of Veterinary Medicine, University College Dublin, Dublin 4, Ireland

    Kerri M. Malone & Stephen V. Gordon

  2. UCD School of Medicine, University College Dublin, Dublin 4, Ireland

    Stephen V. Gordon

  3. UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland

    Stephen V. Gordon

  4. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland

    Stephen V. Gordon

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    Sebastien Gagneux

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Malone, K.M., Gordon, S.V. (2017). Mycobacterium tuberculosis Complex Members Adapted to Wild and Domestic Animals. In: Gagneux, S. (eds) Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control. Advances in Experimental Medicine and Biology, vol 1019. Springer, Cham. https://doi.org/10.1007/978-3-319-64371-7_7

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