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Candida and Candidiasis

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Abstract

Candida species comprehend a wide group of opportunistic pathogens that usually form a part of the microbiota on human linings. Under specific conditions such as immune depression, tissue invasion and infection may occur. Candida infections are ranked as the sixth most common cause of nosocomial infections according to studies by the Centers for Disease Control and Prevention, thus constituting a serious public health problem. Candida albicans has been the most studied member of this species; nevertheless, non-albicans species have risen as emergent pathogens in many regions across the globe. This text presents an outlook of Candida and its infections, including the historical aspects of the fungus, epidemiology and clinical manifestations of the infection, diagnostic techniques as well as treatment guidelines.

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References

  1. Sharma Y, Chumber S, Kaur M (2017) Studying the prevalence, species distribution, and detection of in vitro production of phospholipase from Candida isolated from cases of invasive candidiasis. J Global Infect Dis 9(1):8–11

    Article  Google Scholar 

  2. Sheevani, Sharma P, Aggarwal A (2013) Nosocomial Candida infection in a rural tertiary care hospital. J Clin Diagn Res 7(2):405–406

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Pfaller MA, Diekema DJ (2007 Jan) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20(1):133–163

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Leff S (1956) From witchcraft to world health. Lawrence and Wishart, London

    Google Scholar 

  5. Ship JA (1996) Recurrent aphthous stomatitis. An update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81(2):141–147

    Article  CAS  PubMed  Google Scholar 

  6. Rosén von Rosenstein N (1764) Underrälttelser om barn-sjukdomar och deras botemedel. Kongl. Wet. Acad., Stockholm

    Google Scholar 

  7. Langenbeck B (1839) Auffindung von Pilzen auf der Schleimhaut der Speiseröhre einer Typhus-Leiche. Neue Notizen aus dem Gebiete der Natur-und Heilkunde 12(252): columns 145–147

    Google Scholar 

  8. DIa G (2014) Tapeworms, lice and prions : a compendium of unpleasant infections. Oxford University Press, Oxford

    Google Scholar 

  9. Robin CP (1853) Hlstotre Naturelle des vegdtaux parasites qut crolssent Sur l’homme et sur les animaux vivants, Paris

    Google Scholar 

  10. Barnett JA (2008) A history of research on yeasts 12: medical yeasts part 1, Candida albicans. Yeast 25(6):385–417

    Article  CAS  PubMed  Google Scholar 

  11. Laurent E (1889) Observations sur le champignon du muguet. Bulletin de la Societé Belge de Microscopie 16:14–18

    Google Scholar 

  12. Zopf WF (1890) Die Pilze in morphologischer, physiologischer, biologischer und systematischer beziehung. Encyklopaedie der Naturwissenschaften. The University of Michigan, E. Trewendt

    Google Scholar 

  13. Mello FLG (1918) Arq Hig Pat Exot:207–316

    Google Scholar 

  14. Brownlie & Shattock (1920) J Laryng Rhin Otol 34:425–431

    Google Scholar 

  15. Berkhout CM (1923) De Schimmelgeslachten Monilia, Oidium, Oospora en Torula (Thesis). Rijksuniversiteit te Utrecht

    Google Scholar 

  16. Ota M (1928) Champignons parasites de l’homme. VI (Études morphologiques et systématiques) [In Japanese]. Jpn J Dermatol Urol 28(16–23):381–424

    Google Scholar 

  17. Dekker NM (1931) Endomycopsis albicans (Vuill.) Verh. K. Akad. Wet., tweede sect 28:231

    Google Scholar 

  18. Stelling-Dekker NM (1931) Die sporogenen Hefen. Koninklijke Akademie van Wetenschappen te A, editor, Amsterdam

    Google Scholar 

  19. Benham RW (1931) Certain Monilias parasitic on man. Their identification by morphology and by agglutination. J Infect Dis 49:183–215

    Article  Google Scholar 

  20. Benham RW (1932) Monilias, yeasts, and cryptococci: their pathogenicity, classification, and identification. Am J Public Health Nations Health 22(5):502–504

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Dodge CW (1935) Medical mycology. Fungous diseases of men and other mammals. St. Louis, The C.V. Mosby Company

    Google Scholar 

  22. Langeron M, Guerra P (1938) Nouvelles recherches de zymologie medicare. Ann Parasitol Hum Comp 16(5):429–476

    Article  Google Scholar 

  23. Nickerson WJ (1953) Reduction of inorganic substances by yeasts. I. Extracellular reduction of sulfite by species of Candida. J Infect Dis 93(1):43–56

    Article  CAS  PubMed  Google Scholar 

  24. Nickerson WJ (1954) An enzymatic locus participating in cellular division of a yeast. J Gen Physiol 37(4):483–494

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Meinhof W, Schirren C (2014) Hans Rieth, 1914-1994: to commemorate the occasion of his 100th birthday. Hautarzt 65(11):998–1003. Hans Rieth, 1914-1994: Zum Gedenken anlasslich seines 100. Geburtstages

    Article  CAS  PubMed  Google Scholar 

  26. Slutsky B, Buffo J, Soll DR (1985) High-frequency switching of colony morphology in Candida albicans. Science 230(4726):666–669

    Article  CAS  PubMed  Google Scholar 

  27. Chibana H, Magee BB, Grindle S, Ran Y, Scherer S, Magee PT (1998) A physical map of chromosome 7 of Candida albicans. Genetics 149(4):1739–1752

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Hull CM, Johnson AD (1999) Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans. Science 285(5431):1271–1275

    Article  CAS  PubMed  Google Scholar 

  29. Chibana H, Beckerman JL, Magee PT (2000) Fine-resolution physical mapping of genomic diversity in Candida albicans. Genome Res 10(12):1865–1877

    Article  CAS  PubMed  Google Scholar 

  30. Kandasamy R, Vediyappan G, Chaffin WL (2000) Evidence for the presence of pir-like proteins in Candida albicans. FEMS Microbiol Lett 186(2):239–243

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Fidel PL Jr, Cutright J, Steele C (2000) Effects of reproductive hormones on experimental vaginal candidiasis. Infect Immun 68(2):651–657

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Anderson JB, Wickens C, Khan M, Cowen LE, Federspiel N, Jones T et al (2001) Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans. J Bacteriol 183(3):865–872

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB et al (2004) The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A 101(19):7329–7334

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. de Groot PW, de Boer AD, Cunningham J, Dekker HL, de Jong L, Hellingwerf KJ et al (2004) Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins. Eukaryot Cell 3(4):955–965

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  35. Chibana H, Oka N, Nakayama H, Aoyama T, Magee BB, Magee PT et al (2005) Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome. Genetics 170(4):1525–1537

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Thomas DP, Bachmann SP, Lopez-Ribot JL (2006) Proteomics for the analysis of the Candida albicans biofilm lifestyle. Proteomics 6(21):5795–5804

    Article  CAS  PubMed  Google Scholar 

  37. van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H et al (2007) Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol 8(4):R52

    Article  CAS  Google Scholar 

  38. Oliveira MA, Carvalho LP, Gomes Mde S, Bacellar O, Barros TF, Carvalho EM (2007) Microbiological and immunological features of oral candidiasis. Microbiol Immunol 51(8):713–719

    Article  PubMed  Google Scholar 

  39. Yeater KM, Chandra J, Cheng G, Mukherjee PK, Zhao X, Rodriguez-Zas SL et al (2007) Temporal analysis of Candida albicans gene expression during biofilm development. Microbiology 153(Pt 8):2373–2385

    Article  CAS  PubMed  Google Scholar 

  40. Butler G, Rasmussen MD, Lin MF, Santos MAS, Sakthikumar S, Munro CA et al (2009) Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459(7247):657–662

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Martinez-Gomariz M, Perumal P, Mekala S, Nombela C, Chaffin WL, Gil C (2009 Apr) Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans. Proteomics 9(8):2230–2252

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Nicholls S, MacCallum DM, Kaffarnik FA, Selway L, Peck SC, Brown AJ (2011) Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans. Fungal Genet Biol 48(3):297–305

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Muzzey D, Schwartz K, Weissman JS, Sherlock G (2013) Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol 14(9):R97

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  44. Bartelli TF, Ferreira RC, Colombo AL, Briones MR (2013) Intraspecific comparative genomics of Candida albicans mitochondria reveals non-coding regions under neutral evolution. Infect Genet Evol 14:302–312

    Article  CAS  PubMed  Google Scholar 

  45. Maiti P, Ghorai P, Ghosh S, Kamthan M, Tyagi RK, Datta A (2015) Mapping of functional domains and characterization of the transcription factor Cph1 that mediate morphogenesis in Candida albicans. Fungal Genet Biol 83:45–57

    Article  CAS  PubMed  Google Scholar 

  46. Rajendran R, May A, Sherry L, Kean R, Williams C, Jones BL et al (2016) Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping. Sci Rep 6:35436

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Leach MD, Farrer RA, Tan K, Miao Z, Walker LA, Cuomo CA et al (2016) Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans. Nat Commun 7:11704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Cevik R, Tekin R, Gem M (2016) Candida arthritis in a patient diagnosed with spondyloarthritis. Rev Soc Bras Med Trop 49(6):793–795

    Article  PubMed  Google Scholar 

  49. Zhou PR, Hua H, Liu XS (2017) Quantity of Candida colonies in saliva: a diagnostic evaluation for oral candidiasis. Chin J Dent Res 20(1):27–32

    PubMed  Google Scholar 

  50. Spampinato C, Leonardi D (2013) Candida infections, causes, targets, and resistance mechanisms: traditional and alternative antifungal agents. Biomed Res Int 2013:204237

    PubMed  PubMed Central  Google Scholar 

  51. Gow NAR, van de Veerdonk FL, Brown AJP, Netea MG (2011) Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol 10(2):112–122

    PubMed  PubMed Central  Google Scholar 

  52. Odds FC (2008) Evolution of pathogenic Candida species. Evolutionary biology of bacterial and fungal pathogens. American Society of Microbiology

    Google Scholar 

  53. Pemán J, Cantón E, Quindós G, Eraso E, Alcoba J, Guinea J et al (2012) Epidemiology, species distribution and in vitro antifungal susceptibility of fungaemia in a Spanish multicentre prospective survey. J Antimicrob Chemother 67(5):1181–1187

    Article  PubMed  CAS  Google Scholar 

  54. Ruiz Gaitan AC, Moret A, Lopez Hontangas JL, Molina JM, Aleixandre Lopez AI, Cabezas AH et al (2017) Nosocomial fungemia by Candida auris: first four reported cases in continental Europe. Rev Iberoam Micol 34(1):23–27

    Article  PubMed  Google Scholar 

  55. Hazen KC (1995) New and emerging yeast pathogens. Clin Microbiol Rev 8(4):462–478

    CAS  PubMed  PubMed Central  Google Scholar 

  56. BA MM, Coleman DC (2014) Molecular epidemiology, phylogeny and evolution of Candida albicans. Infect Genet Evol 21:166–178

    Article  Google Scholar 

  57. Fidel PL, Vazquez JA, Sobel JD (1999) Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev 12(1):80–96

    PubMed  PubMed Central  Google Scholar 

  58. Trofa D, Gácser A, Nosanchuk JD (2008) Candida parapsilosis, an emerging fungal pathogen. Clin Microbiol Rev 21(4):606–625

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Almirante B, Rodriguez D, Cuenca-Estrella M, Almela M, Sanchez F, Ayats J et al (2006) Epidemiology, risk factors, and prognosis of Candida parapsilosis bloodstream infections: case-control population-based surveillance study of patients in Barcelona, Spain, from 2002 to 2003. J Clin Microbiol 44(5):1681–1685

    Article  PubMed  PubMed Central  Google Scholar 

  60. de Toro M, Torres MJ, Maite R, Aznar J (2011) Characterization of Candida parapsilosis complex isolates. Clin Microbiol Infect 17(3):418–424

    Article  PubMed  Google Scholar 

  61. Álvarez-Lerma F, Nolla-Salas J, León C, Palomar M, Jordá R, Carrasco N et al (2003) Candiduria in critically ill patients admitted to intensive care medical units. Intensive Care Med 29(7):1069–1076

    Article  PubMed  Google Scholar 

  62. Binelli CA, Moretti ML, Assis RS, Sauaia N, Menezes PR, Ribeiro E et al (2006) Investigation of the possible association between nosocomial candiduria and candidaemia. Clin Microbiol Infect 12(6):538–543

    Article  CAS  PubMed  Google Scholar 

  63. Colombo AL, Guimarães T, LRBF S, LPDA M, AKB C, Rady P et al (2007) Prospective Observational Study of Candidemia in São Paulo, Brazil: incidence rate, epidemiology, and predictors of mortality. Infect Control Hosp Epidemiol 28(5):570–576

    Article  PubMed  Google Scholar 

  64. Ann Chai LY, Denning DW, Warn P (2010) Candida tropicalis in human disease. Crit Rev Microbiol 36(4):282–298

    Article  CAS  Google Scholar 

  65. Suzuki T, Miyamae Y, Ishida I (1991) Variation of colony morphology and chromosomal rearrangement in Candida tropicalis pK233. Microbiology 137(1):161–167

    CAS  Google Scholar 

  66. Martin MV (1979) Germ-tube formation by oral strains of Candida tropicalis. J Med Microbiol 12(2):187–194

    Article  CAS  PubMed  Google Scholar 

  67. Doi M, Homma M, Chindamporn A, Tanaka K (1992) Estimation of chromosome number and size by pulsed-field gel electrophoresis (PFGE) in medically important Candida species. Microbiology 138(10):2243–2251

    CAS  Google Scholar 

  68. Pfaller MA, Andes DR, Diekema DJ, Horn DL, Reboli AC, Rotstein C et al (2014) Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the prospective antifungal therapy (PATH) registry 2004–2008. PLoS One 9(7):e101510

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  69. Presterl E, Daxböck F, Graninger W, Willinger B (2007) Changing pattern of candidaemia 2001–2006 and use of antifungal therapy at the University Hospital of Vienna, Austria. Clin Microbiol Infect 13(11):1072–1076

    Article  CAS  PubMed  Google Scholar 

  70. Pfaller MA, Diekema DJ (2010) Epidemiology of invasive mycoses in North America. Crit Rev Microbiol 36(1):1–53

    Article  PubMed  Google Scholar 

  71. Li XS, Reddy MS, Baev D, Edgerton M (2003) Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. J Biol Chem 278(31):28553–28561

    Article  CAS  PubMed  Google Scholar 

  72. Baddley JW, Patel M, Bhavnani SM, Moser SA, Andes DR (2008) Association of fluconazole pharmacodynamics with mortality in patients with candidemia. Antimicrob Agents Chemother 52(9):3022–3028

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Kaufmann CS, Merz WG (1989) Electrophoretic karyotypes of Torulopsis glabrata. J Clin Microbiol 27(10):2165–2168

    CAS  PubMed  PubMed Central  Google Scholar 

  74. DiazGranados CA, Martinez A, Deaza C, Valderrama S (2008) An outbreak of Candida spp. bloodstream infection in a tertiary care center in Bogotá, Colombia. Braz J Infect Dis 12:390–394

    Article  PubMed  Google Scholar 

  75. Strollo S, Lionakis MS, Adjemian J, Steiner CA, Prevots DR (2017) Epidemiology of hospitalizations associated with invasive candidiasis, United States, 2002–2012. Emerg Infect Dis J 23(1):7

    Article  Google Scholar 

  76. Tortorano AM, Peman J, Bernhardt H, Klingspor L, Kibbler CC, Faure O et al (2004) Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study. Eur J Clin Microbiol Infect Dis 23(4):317–322

    Article  CAS  PubMed  Google Scholar 

  77. Hasan F, Xess I, Wang X, Jain N, Fries BC (2009) Biofilm formation in clinical Candida isolates and its association with virulence. Microbes Infect 11(8–9):753–761

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Horn DL, Neofytos D, Anaissie EJ, Fishman JA, Steinbach WJ, Olyaei AJ et al (2009) Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis 48(12):1695–1703

    Article  CAS  PubMed  Google Scholar 

  79. Sardi JCO, Scorzoni L, Bernardi T, Fusco-Almeida AM, Mendes Giannini MJS (2013) Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol 62(1):10–24

    Article  CAS  PubMed  Google Scholar 

  80. Richardson M, Lass-Flörl C (2008) Changing epidemiology of systemic fungal infections. Clin Microbiol Infect 14:5–24

    Article  PubMed  Google Scholar 

  81. Lass-Flörl C (2009) The changing face of epidemiology of invasive fungal disease in Europe. Mycoses 52(3):197–205

    Article  PubMed  Google Scholar 

  82. Pappas PG. Invasive candidiasis. Infect Dis Clin North Am 2006;20(3):485–506

    Google Scholar 

  83. Weems JJ Jr (1992) Candida parapsilosis: epidemiology, pathogenicity, clinical manifestations, and antimicrobial susceptibility. Clin Infect Dis 14(3):756–766

    Article  PubMed  Google Scholar 

  84. Krcmery V, Barnes AJ (2002) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance. J Hosp Infect 50(4):243–260

    Article  CAS  PubMed  Google Scholar 

  85. Canton E, Peman J, Quindos G, Eraso E, Miranda-Zapico I, Alvarez M et al (2011) Prospective multicenter study of the epidemiology, molecular identification, and antifungal susceptibility of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis isolated from patients with candidemia. Antimicrob Agents Chemother 55(12):5590–5596

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Pfaller MA, Boyken L, Hollis RJ, Messer SA, Tendolkar S, Diekema DJ (2006) Global surveillance of in vitro activity of micafungin against Candida: a comparison with caspofungin by CLSI-recommended methods. J Clin Microbiol 44(10):3533–3538

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Pfaller MA, Boyken L, Hollis RJ, Messer SA, Tendolkar S, Diekema DJ. In vitro susceptibilities of Candida spp. to caspofungin: four years of global surveillance. J Clin Microbiol. 2006;44(3):760–763

    Google Scholar 

  88. Wingard JR (1995) Importance of Candida species other than C. albicans as pathogens in oncology patients. Clin Infect Dis 20(1):115–125

    Article  CAS  PubMed  Google Scholar 

  89. Kao AS, Brandt ME, Pruitt WR, Conn LA, Perkins BA, Stephens DS et al (1999) The epidemiology of candidemia in two United States cities: results of a population-based active surveillance. Clin Infect Dis 29(5):1164–1170

    Article  CAS  PubMed  Google Scholar 

  90. Ortega M, Marco F, Soriano A, Almela M, Martínez JA, López J et al (2011) Candida species bloodstream infection: epidemiology and outcome in a single institution from 1991 to 2008. J Hosp Infect 77(2):157–161

    Article  CAS  PubMed  Google Scholar 

  91. Branchini ML, Pfaller MA, Rhine-Chalberg J, Frempong T, Isenberg HD (1994) Genotypic variation and slime production among blood and catheter isolates of Candida parapsilosis. J Clin Microbiol 32(2):452–456

    CAS  PubMed  PubMed Central  Google Scholar 

  92. Fusek M, Smith EA, Monod M, Foundling SI (1993) Candida parapsilosis expresses and secretes two aspartic proteinases. FEBS Lett 327(1):108–112

    Article  CAS  PubMed  Google Scholar 

  93. Merkerova M, Dostal J, Hradilek M, Pichova I, Hruskova-Heidingsfeldova O (2006) Cloning and characterization of Sapp2p, the second aspartic proteinase isoenzyme from Candida parapsilosis. FEMS Yeast Res 6(7):1018–1026

    Article  CAS  PubMed  Google Scholar 

  94. Miranda LN, van der Heijden IM, Costa SF, Sousa AP, Sienra RA, Gobara S et al (2009) Candida colonisation as a source for candidaemia. J Hosp Infect 72(1):9–16

    Article  CAS  PubMed  Google Scholar 

  95. Hobson RP (2003) The global epidemiology of invasive Candida infections – is the tide turning? J Hosp Infect 55(3):159–168. quiz 233

    Article  CAS  PubMed  Google Scholar 

  96. Brito LR, Guimaraes T, Nucci M, Rosas RC, Paula Almeida L, Da Matta DA et al (2006) Clinical and microbiological aspects of candidemia due to Candida parapsilosis in Brazilian tertiary care hospitals. Med Mycol 44(3):261–266

    Article  PubMed  Google Scholar 

  97. Kauffman CA, Vazquez JA, Sobel JD, Gallis HA, McKinsey DS, Karchmer AW et al (2000) Prospective multicenter surveillance study of funguria in hospitalized patients. The National Institute for Allergy and Infectious Diseases (NIAID) Mycoses Study Group. Clin Infect Dis 30(1):14–18

    Article  CAS  PubMed  Google Scholar 

  98. Rho J, Shin JH, Song JW, Park MR, Kee SJ, Jang SJ et al (2004) Molecular investigation of two consecutive nosocomial clusters of Candida tropicalis candiduria using pulsed-field gel electrophoresis. J Microbiol 42(2):80–86

    CAS  PubMed  Google Scholar 

  99. Negri M, Goncalves V, Silva S, Henriques M, Azeredo J, Oliveira R (2010) Crystal violet staining to quantify Candida adhesion to epithelial cells. Br J Biomed Sci 67(3):120–125

    Article  CAS  PubMed  Google Scholar 

  100. Chakrabarti A, Sood P, Rudramurthy SM, Chen S, Kaur H, Capoor M et al (2015) Incidence, characteristics and outcome of ICU-acquired candidemia in India. Intensive Care Med 41(2):285–295

    Article  PubMed  Google Scholar 

  101. Hii I-M, Chang H-L, Lin L-C, Lee Y-L, Liu Y-M, Liu C-E et al (2015) Changing epidemiology of candidemia in a medical center in middle Taiwan. J Microbiol Immunol Infect 48(3):306–315

    Article  PubMed  Google Scholar 

  102. Hofs S, Mogavero S, Hube B (2016) Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J Microbiol 54(3):149–169

    Article  PubMed  CAS  Google Scholar 

  103. Yang YL (2003) Virulence factors of Candida species. J Microbiol Immunol Infect 36(4):223–228

    CAS  PubMed  Google Scholar 

  104. Moyes DL, Richardson JP, Naglik JR (2015) Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface. Virulence 6(4):338–346

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Modrzewska B, Kurnatowski P (2015) Adherence of Candida sp. to host tissues and cells as one of its pathogenicity features. Ann Parasitol 61(1):3–9

    PubMed  Google Scholar 

  106. Staab JF, Bahn YS, Tai CH, Cook PF, Sundstrom P (2004) Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification. J Biol Chem 279(39):40737–40747

    Article  CAS  PubMed  Google Scholar 

  107. Zhu W, Filler SG (2010) Interactions of Candida albicans with epithelial cells. Cell Microbiol 12(3):273–282

    Article  CAS  PubMed  Google Scholar 

  108. Calderone RA, Fonzi WA (2001) Virulence factors of Candida albicans. Trends Microbiol 9(7):327–335

    Article  CAS  PubMed  Google Scholar 

  109. Biswas S, Van Dijck P, Datta A (2007) Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans. Microbiol Mol Biol Rev 71(2):348–376

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Jacobsen ID, Wilson D, Wachtler B, Brunke S, Naglik JR, Hube B (2012) Candida albicans dimorphism as a therapeutic target. Expert Rev Anti-Infect Ther 10(1):85–93

    Article  PubMed  Google Scholar 

  111. Sudbery PE (2011) Growth of Candida albicans hyphae. Nat Rev Micro 9(10):737–748

    Article  CAS  Google Scholar 

  112. Mayer FL, Wilson D, Hube B (2013) Candida albicans pathogenicity mechanisms. Virulence 4(2):119–128

    Article  PubMed  PubMed Central  Google Scholar 

  113. Clancy CJ, Barchiesi F, Falconi DiFrancesco L, Morris AJ, Snydman DR, Yu VL et al (2000) Clinical manifestations and molecular epidemiology of late recurrent candidemia, and implications for management. Eur J Clin Microbiol Infect Dis 19(8):585–592

    Article  CAS  PubMed  Google Scholar 

  114. Tang HJ, Liu WL, Lin HL, Lai CC (2014) Clinical manifestations and prognostic factors of central line-associated candidemia. Am J Infect Control 42(11):1238–1240

    Article  PubMed  Google Scholar 

  115. Patel SK, Shah DR, Tiwari S (2015) Bioadhesive films containing fluconazole for mucocutaneous candidiasis. Indian J Pharm Sci 77(1):55–61

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Khullar G, Vignesh P, Lau YL, Rudramurthy SM, Rawat A, De D et al (2017) Chronic mucocutaneous candidiasis. J Allergy Clin Immunol Pract 5(4):1119–1121

    Article  PubMed  Google Scholar 

  117. Puel A, Picard C, Cypowyj S, Lilic D, Abel L, Casanova JL (2010) Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines? Curr Opin Immunol 22(4):467–474

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  118. Marazzi MG, Bondi E, Giannattasio A, Strozzi M, Savioli C (2008) Intracranial aneurysm associated with chronic mucocutaneous candidiasis. Eur J Pediatr 167(4):461–463

    Article  CAS  PubMed  Google Scholar 

  119. Rautemaa R, Hietanen J, Niissalo S, Pirinen S, Perheentupa J (2007) Oral and oesophageal squamous cell carcinoma – a complication or component of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, APS-I). Oral Oncol 43(6):607–613

    Article  PubMed  Google Scholar 

  120. Eyerich K, Eyerich S, Hiller J, Behrendt H, Traidl-Hoffmann C (2010) Chronic mucocutaneous candidiasis, from bench to bedside. Eur J Dermatol 20(3):260–265

    CAS  PubMed  Google Scholar 

  121. Bassetti M, Marchetti M, Chakrabarti A, Colizza S, Garnacho-Montero J, Kett DH et al (2013) A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts. Intensive Care Med 39(12):2092–2106

    Article  PubMed  Google Scholar 

  122. Vergidis P, Clancy CJ, Shields RK, Park SY, Wildfeuer BN, Simmons RL et al (2016) Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment. PLoS One 11(4):e0153247

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  123. Bassetti M, Righi E, Ansaldi F, Merelli M, Scarparo C, Antonelli M et al (2015) A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality. Intensive Care Med 41(9):1601–1610

    Article  PubMed  Google Scholar 

  124. Montravers P, Dupont H, Gauzit R, Veber B, Auboyer C, Blin P et al (2006) Candida as a risk factor for mortality in peritonitis. Crit Care Med 34(3):646–652

    Article  PubMed  Google Scholar 

  125. Murray HW, Fialk MA, Roberts RB (1976) Candida arthritis. A manifestation of disseminated candidiasis. Am J Med 60(4):587–595

    Article  CAS  PubMed  Google Scholar 

  126. Fainstein V, Gilmore C, Hopfer RL, Maksymiuk A, Bodey GP (1982) Septic arthritis due to Candida species on patients with cancer: report of five cases and review of the literature. Rev Infect Dis 4(1):78–85

    Article  CAS  PubMed  Google Scholar 

  127. Munoz-Fernandez S, Macia MA, Pantoja L, Cardenal A, Pena JM, Martin Mola E et al (1993) Osteoarticular infection in intravenous drug abusers: influence of HIV infection and differences with non drug abusers. Ann Rheum Dis 52(8):570–574

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  128. Gamaletsou MN, Rammaert B, Bueno MA, Sipsas NV, Moriyama B, Kontoyiannis DP et al (2016) Candida arthritis: analysis of 112 pediatric and adult cases. Open Forum Infect Dis 3(1):ofv207

    PubMed  Google Scholar 

  129. Jones JM (1990) Laboratory diagnosis of invasive candidiasis. Clin Microbiol Rev 3(1):32–45

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  130. Pfeiffer CD, Samsa GP, Schell WA, Reller LB, Perfect JR, Alexander BD (2011) Quantitation of Candida CFU in initial positive blood cultures. J Clin Microbiol 49(8):2879–2883

    Article  PubMed  PubMed Central  Google Scholar 

  131. Clancy CJ, Nguyen ML, Cheng S, Huang H, Fan G, Jaber RA et al (2008) Immunoglobulin G responses to a panel of Candida albicans antigens as accurate and early markers for the presence of systemic candidiasis. J Clin Microbiol 46(5):1647–1654

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. Martinez-Jimenez MC, Munoz P, Valerio M, Vena A, Guinea J, Bouza E (2015) Combination of Candida biomarkers in patients receiving empirical antifungal therapy in a Spanish tertiary hospital: a potential role in reducing the duration of treatment. J Antimicrob Chemother 70(11):3107–3115

    Article  CAS  PubMed  Google Scholar 

  133. Martinez-Jimenez MC, Munoz P, Valerio M, Vena A, Guinea J, Bouza E (2016) Combination of Candida biomarkers in patients receiving empirical antifungal therapy in a Spanish tertiary hospital: a potential role in reducing the duration of treatment. J Antimicrob Chemother 71(9):2679

    Article  PubMed  Google Scholar 

  134. He Z-X, Shi L-C, Ran X-Y, Li W, Wang X-L, Wang F-K (2016) Development of a lateral flow immunoassay for the rapid diagnosis of invasive candidiasis. Front Microbiol 7:1451

    PubMed  PubMed Central  Google Scholar 

  135. Borst A, Theelen B, Reinders E, Boekhout T, Fluit AC, Savelkoul PHM (2003) Use of amplified fragment length polymorphism analysis to identify medically important Candida spp., including C. dubliniensis. J Clin Microbiol 41(4):1357–1362

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  136. Coleman D, Sullivan D, Harrington B, Haynes K, Henman M, Shanley D et al (1997) Molecular and phenotypic analysis of Candida dubliniensis: a recently identified species linked with oral candidosis in HIV-infected and AIDS patients. Oral Dis 3(Suppl 1):S96–101

    Article  PubMed  Google Scholar 

  137. Elie CM, Lott TJ, Reiss E, Morrison CJ (1998) Rapid identification of Candida species with species-specific DNA probes. J Clin Microbiol 36(11):3260–3265

    CAS  PubMed  PubMed Central  Google Scholar 

  138. Ellepola AN, Hurst SF, Elie CM, Morrison CJ (2003) Rapid and unequivocal differentiation of Candida dubliniensis from other Candida species using species-specific DNA probes: comparison with phenotypic identification methods. Oral Microbiol Immunol 18(6):379–388

    Article  CAS  PubMed  Google Scholar 

  139. Graf B, Trost A, Eucker J, Gobel UB, Adam T (2004) Rapid and simple differentiation of C. dubliniensis from C. albicans. Diagn Microbiol Infect Dis 48(2):149–151

    Article  CAS  PubMed  Google Scholar 

  140. Joly S, Pujol C, Rysz M, Vargas K, Soll DR (1999) Development and characterization of complex DNA fingerprinting probes for the infectious yeast Candida dubliniensis. J Clin Microbiol 37(4):1035–1044

    CAS  PubMed  PubMed Central  Google Scholar 

  141. McCullough M, Ross B, Reade P (1995) Characterization of genetically distinct subgroup of Candida albicans strains isolated from oral cavities of patients infected with human immunodeficiency virus. J Clin Microbiol 33(3):696–700

    CAS  PubMed  PubMed Central  Google Scholar 

  142. Fatima A, Bashir G, Wani T, Jan A, Kohli A, Khan MS (2017) Molecular identification of Candida species isolated from cases of neonatal candidemia using polymerase chain reaction-restriction fragment length polymorphism in a tertiary care hospital. Indian J Pathol Microbiol 60(1):61–65

    PubMed  Google Scholar 

  143. Khodadadi H, Karimi L, Jalali-Zand N, Adin H, Mirhendi H (2017) Utilization of size polymorphism in ITS1 and ITS2 regions for identification of pathogenic yeast species. J Med Microbiol 66(2):126–133

    Article  PubMed  Google Scholar 

  144. McMullan R, Metwally L, Coyle PV, Hedderwick S, McCloskey B, O'Neill HJ et al (2008) A prospective clinical trial of a real-time polymerase chain reaction assay for the diagnosis of candidemia in nonneutropenic, critically ill adults. Clin Infect Dis 46(6):890–896

    Article  CAS  PubMed  Google Scholar 

  145. Lucignano B, Ranno S, Liesenfeld O, Pizzorno B, Putignani L, Bernaschi P et al (2011) Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis. J Clin Microbiol 49(6):2252–2258

    Article  PubMed  PubMed Central  Google Scholar 

  146. Posteraro B, Sanguinetti M, Masucci L, Romano L, Morace G, Fadda G (2000) Reverse cross blot hybridization assay for rapid detection of PCR-amplified DNA from Candida species, Cryptococcus neoformans, and Saccharomyces cerevisiae in clinical samples. J Clin Microbiol 38(4):1609–1614

    CAS  PubMed  PubMed Central  Google Scholar 

  147. Leinberger DM, Schumacher U, Autenrieth IB, Bachmann TT (2005) Development of a DNA microarray for detection and identification of fungal pathogens involved in invasive mycoses. J Clin Microbiol 43(10):4943–4953

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  148. Baskova L, Landlinger C, Preuner S, Lion T (2007) The Pan-AC assay: a single-reaction real-time PCR test for quantitative detection of a broad range of Aspergillus and Candida species. J Med Microbiol 56(Pt 9):1167–1173

    Article  CAS  PubMed  Google Scholar 

  149. Schabereiter-Gurtner C, Selitsch B, Rotter ML, Hirschl AM, Willinger B (2007) Development of novel real-time PCR assays for detection and differentiation of eleven medically important Aspergillus and Candida species in clinical specimens. J Clin Microbiol 45(3):906–914

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  150. Nabili M, Ashrafi M, Janbabaie G, Hedayati MT, Ali-Moghaddam K, Shokohi T (2013) Quantification and optimization of Candida albicans DNA in blood samples using Real- Time PCR. Rep Biochem Mol Biol 2(1):42–47

    PubMed  PubMed Central  Google Scholar 

  151. Odds FC, Bougnoux ME, Shaw DJ, Bain JM, Davidson AD, Diogo D et al (2007) Molecular phylogenetics of Candida albicans. Eukaryot Cell 6(6):1041–1052

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Odds FC (2010) Molecular phylogenetics and epidemiology of Candida albicans. Future Microbiol 5(1):67–79

    Article  CAS  PubMed  Google Scholar 

  153. Afsarian SM, Badali H, Shokohi T, Najafipour S (2015) Molecular diversity of Candida albicans isolated from immunocompromised patients, based on MLST method. Iran J Public Health 44(9):1262–1269

    PubMed  PubMed Central  Google Scholar 

  154. Marot-Leblond A, Beucher B, David S, Nail-Billaud S, Robert R (2006) Development and evaluation of a rapid latex agglutination test using a monoclonal antibody to identify Candida dubliniensis colonies. J Clin Microbiol 44(1):138–142

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  155. Karageorgopoulos DE, Vouloumanou EK, Ntziora F, Michalopoulos A, Rafailidis PI, Falagas ME (2011) β-D-Glucan assay for the diagnosis of invasive fungal infections: a meta-analysis. Clin Infect Dis 52(6):750–770

    Article  CAS  PubMed  Google Scholar 

  156. Saez-Roson A, Sevilla MJ, Moragues MD (2014) Identification of superficial Candida albicans germ tube antigens in a rabbit model of disseminated candidiasis. A proteomic approach. Int Microbiol 17(1):21–29

    CAS  PubMed  Google Scholar 

  157. Yeo SF, Zhang Y, Schafer D, Campbell S, Wong B (2000) A rapid, automated enzymatic fluorometric assay for determination of D-arabinitol in serum. J Clin Microbiol 38(4):1439–1443

    CAS  PubMed  PubMed Central  Google Scholar 

  158. Pappas PG, Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ et al (2004) Guidelines for treatment of candidiasis. Clin Infect Dis 38(2):161–189

    Article  PubMed  Google Scholar 

  159. Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L et al (2016) Clinical practice guideline for the management of candidiasis: 2016 update by the infectious diseases Society of America. Clin Infect Dis 62(4):e1–50

    Article  PubMed  Google Scholar 

  160. Bondaryk M, Kurzątkowski W, Staniszewska M (2013) Antifungal agents commonly used in the superficial and mucosal candidiasis treatment: mode of action and resistance development. Adv Dermatol Allergol/Postȩpy Dermatol Alergol 30(5):293–301

    Article  Google Scholar 

  161. Dias MFRG, Bernardes-Filho F, Quaresma-Santos MVP, AGDF A, Schechtman RC, Azulay DR (2013) Treatment of superficial mycoses: review – part II. An Bras Dermatol 88(6):937–944

    Article  PubMed  PubMed Central  Google Scholar 

  162. Achkar JM, Fries BC (2010) Candida infections of the genitourinary tract. Clin Microbiol Rev 23(2):253–273

    Article  PubMed  PubMed Central  Google Scholar 

  163. Netea MG, Joosten LA, van der Meer JW, Kullberg BJ, van de Veerdonk FL (2015) Immune defence against Candida fungal infections. Nat Rev Immunol 15(10):630–642

    Article  CAS  PubMed  Google Scholar 

  164. Netea MG, Quintin J, van der Meer JW (2011) Trained immunity: a memory for innate host defense. Cell Host Microbe 9(5):355–361

    Article  CAS  PubMed  Google Scholar 

  165. Bistoni F, Verducci G, Perito S, Vecchiarelli A, Puccetti P, Marconi P et al (1988) Immunomodulation by a low-virulence, agerminative variant of Candida albicans. Further evidence for macrophage activation as one of the effector mechanisms of nonspecific anti-infectious protection. J Med Vet Mycol 26(5):285–299

    Article  CAS  PubMed  Google Scholar 

  166. Reales-Calderon JA, Aguilera-Montilla N, Corbi AL, Molero G, Gil C (2014) Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response to Candida albicans. Proteomics 14(12):1503–1518

    Article  CAS  PubMed  Google Scholar 

  167. Gantner BN, Simmons RM, Underhill DM (2005) Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J 24(6):1277–1286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Pérez-García, L.A. et al. (2017). Candida and Candidiasis. In: Mora-Montes, H., Lopes-Bezerra, L. (eds) Current Progress in Medical Mycology. Springer, Cham. https://doi.org/10.1007/978-3-319-64113-3_3

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