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Sporothrix and Sporotrichosis

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Current Progress in Medical Mycology

Abstract

Sporotrichosis is the mycosis due to implantation of greatest global distribution. It is caused by a complex of thermodymorphic fungi of cryptic species, of which the most frequent and important are Sporothrix schenckii and Sporothrix brasiliensis. These fungi live in nature, matter in decomposition and several plants. The route of entry usually involves traumatic inoculation, but sometimes it could be by the respiratory route. In general, they produce a condition confined to the subcutaneous cellular tissue and, to a lesser extent, affect various viscera, such as the lungs and central nervous system. Clinically, it is a polymorphic condition with various manifestations depending mainly on the patient’s immune status and strain virulence. In cases associated with immunosuppression, cutaneous and extracutaneous features may occur. The main clinical form is lymphangitic cutaneous sporotrichosis. In this chapter, the authors discuss the biological aspects of the main pathogenic species of the Sporothrix schenckii complex, including virulence factors, clinical-epidemiological aspects, diagnosis, and treatment.

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Authors and Affiliations

  1. Laboratory of Cellular Mycology and Proteomics, Biology Institute, University of Rio de Janeiro State (UERJ), Rio de Janeiro, 20550-013, Brazil

    Leila M. Lopes-Bezerra Ph.D.

  2. Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P, 36050, Guanajuato, Gto., Mexico

    Héctor M. Mora-Montes Ph.D.

  3. Department of Mycology and Dermatology Service, Hospital General de México, “Dr. Eduardo Liceaga”, Dr. Balmis 148, Col Doctores, CP 06720, Mexico, DF, Mexico

    Alexandro Bonifaz Ph.D.

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  1. Leila M. Lopes-Bezerra Ph.D.
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  1. Universidad de Guanajuato, Guanajuato, Mexico

    Héctor M. Mora-Montes

  2. Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

    Leila M. Lopes-Bezerra

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Lopes-Bezerra, L.M., Mora-Montes, H.M., Bonifaz, A. (2017). Sporothrix and Sporotrichosis. In: Mora-Montes, H., Lopes-Bezerra, L. (eds) Current Progress in Medical Mycology. Springer, Cham. https://doi.org/10.1007/978-3-319-64113-3_10

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