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Copy Number Variation/Chromosomal Aberration

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Precision Molecular Pathology of Prostate Cancer

Part of the book series: Molecular Pathology Library ((MPLB))

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Abstract

Prostate cancer is characterized by recurrent copy number alterations (CNAs) and chromosomal aberrations (CAs). In this chapter, we detail the most common CNAs and CAs encountered in prostate cancer and explore our knowledge of how such alterations are generated. We also describe how such alterations are identified using modern genomic sequencing combined with computational analysis and highlight key validation strategies. Finally, we describe how copy number alterations are sometimes actionable and should form integral part of a prostate cancer precision medicine program.

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Author information

Authors and Affiliations

  1. Caryl and Israel Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA

    Olivier Elemento Ph.D.

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  1. Olivier Elemento Ph.D.
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Correspondence to Olivier Elemento Ph.D. .

Editor information

Editors and Affiliations

  1. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Brian D. Robinson

  2. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Juan Miguel Mosquera

  3. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Jae Y. Ro

  4. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Mukul Divatia

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Elemento, O. (2018). Copy Number Variation/Chromosomal Aberration. In: Robinson, B., Mosquera, J., Ro, J., Divatia, M. (eds) Precision Molecular Pathology of Prostate Cancer. Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-64096-9_9

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  • DOI: https://doi.org/10.1007/978-3-319-64096-9_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-64094-5

  • Online ISBN: 978-3-319-64096-9

  • eBook Packages: MedicineMedicine (R0)

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