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Prostate Cancer Molecular Prognosis

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Precision Molecular Pathology of Prostate Cancer

Part of the book series: Molecular Pathology Library ((MPLB))

Abstract

Prostate cancer is biologically and clinically diverse-tumors ranging from small, indolent tumors that will never clinically manifest, to aggressive carcinomas that readily metastasize and cause mortality. While several pathologic and clinical variables, such as Gleason score and serum prostate-specific antigen level, are valuable for prognosis, several clinical situations exist in which these variables do not inform fully on tumor behavior and patient management. Molecular tests may be useful in these clinical situations, such as active surveillance. Many tests have been developed and are in development and may be done on tissue or urine specimens. This chapter will review the prognostic value of several molecular tests for prostate cancer, in the context of known pathologic and clinical prognostic variables.

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Authors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Joshua I. Warrick M.D.

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Scott A. Tomlins M.D., Ph.D.

  3. Department of Urology, University of Michigan Medical School, Ann Arbor, MI, USA

    Scott A. Tomlins M.D., Ph.D.

  4. Michigan Center for Translational Pathology, Ann Arbor, MI, USA

    Scott A. Tomlins M.D., Ph.D.

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  1. Joshua I. Warrick M.D.
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Correspondence to Scott A. Tomlins M.D., Ph.D. .

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Editors and Affiliations

  1. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Brian D. Robinson

  2. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Juan Miguel Mosquera

  3. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Jae Y. Ro

  4. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Mukul Divatia

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Warrick, J.I., Tomlins, S.A. (2018). Prostate Cancer Molecular Prognosis. In: Robinson, B., Mosquera, J., Ro, J., Divatia, M. (eds) Precision Molecular Pathology of Prostate Cancer. Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-64096-9_28

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