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Prostate Cancer Molecular Prognosis

  • Joshua I. Warrick
  • Scott A. Tomlins
Chapter
Part of the Molecular Pathology Library book series (MPLB)

Abstract

Prostate cancer is biologically and clinically diverse-tumors ranging from small, indolent tumors that will never clinically manifest, to aggressive carcinomas that readily metastasize and cause mortality. While several pathologic and clinical variables, such as Gleason score and serum prostate-specific antigen level, are valuable for prognosis, several clinical situations exist in which these variables do not inform fully on tumor behavior and patient management. Molecular tests may be useful in these clinical situations, such as active surveillance. Many tests have been developed and are in development and may be done on tissue or urine specimens. This chapter will review the prognostic value of several molecular tests for prostate cancer, in the context of known pathologic and clinical prognostic variables.

Keywords

MYC PTEN TP53 Active surveillance qRT-PCR assays Expression profiling 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PathologyPenn State Milton S. Hershey Medical CenterHersheyUSA
  2. 2.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA
  3. 3.Department of UrologyUniversity of Michigan Medical SchoolAnn ArborUSA
  4. 4.Michigan Center for Translational PathologyAnn ArborUSA

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