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Tyrosine Kinase Receptor Signaling in Prostate Cancer

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Precision Molecular Pathology of Prostate Cancer

Part of the book series: Molecular Pathology Library ((MPLB))

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Abstract

Prostate cancer (PCa) is the most common type of cancer in men and one of the leading causes of cancer-related death in Western world (Jemal et al., CA Cancer J Clin 57(1):43–66, 2007; Siegel et al., CA Cancer J Clin 63(1):11–30, 2013). Elevated levels of the male hormones, androgens, are known to contribute to development of PCa. As the growth of PCa at initial stage is dependent on hormones, hormone-deprivation therapies are therefore used as standard treatment to induce tumor regression in PCa patients (Litvinov et al., Proc Natl Acad Sci U S A 103(41):15085–15090, 2006). Despite hormone-deprivation treatment, most of treated PCa will resume the growth and become hormone-refractory, also termed castration-resistant PCa (CRPC) (Litvinov et al., Proc Natl Acad Sci U S A 103(41):15085–15090, 2006; Lindzey et al., Vitam Horm 49:383–432, 1994). CRPC is no longer responsive to most of the available therapies and is highly invasive with metastatic potentials to disseminate to distant organs including the lung, bone, and brain (Semenas et al., Curr Drug Targets 13(10):1308–1323, 2012). Thus, CRPC represents a major clinical challenge.

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Acknowledgments

This work was supported by the grants from the Swedish Cancer Society, the Swedish National Research Council, the Swedish Children Foundation, Malmö Hospital Cancer Foundation, Malmö Hospital Foundation, and Gunnar Nilsson Cancer Foundation. Crafoord Foundation to JLP.

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Authors and Affiliations

  1. Olympia Diagnostics, Inc., Sunnyvale, CA, USA

    Heather Johnson Ph.D.

  2. Institute of Basic Medical Sciences, Beijing, China

    Heather Johnson Ph.D.

  3. Department of Urology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Lingwu Chen M.D., Ph.D.

  4. Department of Urology, The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Shenzhen Urology Minimally Invasive Engineering Center, Shenzhen, China

    Kefeng Xiao M.D., Ph.D.

  5. Department of Translational Medicine, Clinical Research Centre, Lund University, Malmö, Sweden

    Jenny L. Persson Ph.D.

  6. Department of Molecular Biology, Umeå University, Umeå, Sweden

    Jenny L. Persson Ph.D.

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  1. Heather Johnson Ph.D.
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  2. Lingwu Chen M.D., Ph.D.
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  3. Kefeng Xiao M.D., Ph.D.
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  4. Jenny L. Persson Ph.D.
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Correspondence to Jenny L. Persson Ph.D. .

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Editors and Affiliations

  1. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Brian D. Robinson

  2. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Juan Miguel Mosquera

  3. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Jae Y. Ro

  4. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Mukul Divatia

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Johnson, H., Chen, L., Xiao, K., Persson, J.L. (2018). Tyrosine Kinase Receptor Signaling in Prostate Cancer. In: Robinson, B., Mosquera, J., Ro, J., Divatia, M. (eds) Precision Molecular Pathology of Prostate Cancer. Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-64096-9_24

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