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Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma

  • Chapter
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Precision Molecular Pathology of Prostate Cancer

Part of the book series: Molecular Pathology Library ((MPLB))

Abstract

This chapter summarizes the role of stromal cells in the development and progression of prostate cancer and how alterations in gene expression in the tumor-adjacent stroma may be useful for diagnosis and prognosis of prostate cancer. During embryogenesis, prostate stromal cells play a major role in prostate morphogenesis. Prostate stromal cells also play a major role in prostate carcinogenesis and prostate cancer progression. Changes in the stroma of tumor-bearing prostate glands have been used to detect the presence of tumor nearby. Furthermore, since stromal cells exhibit fewer genetic mutations than those in the tumor, gene expression profiles of the tumor-adjacent stromal cells may be a source of reliable biomarkers to predict outcomes during the course of clinical management of patients. The clinical and biological significance of changes in stroma is highlighted.

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Acknowledgments

This work was supported by the NCI Early Detection Research Network (EDRN) Consortium grant U01 CA152738, the NCI Strategic Partner for the Evaluation of Cancer Signatures (SPECS) consortium U01 CA114810, and by bridging funds from the UCI Chao Family Comprehensive Cancer Center Support Grant NCI CA P3062203. This work was also supported in part by Department of Defense Congressionally Directed Medical Research Programs grants W81XWH-08–1-0720, W81XWH-11–1-0312, and W81XWH-14-PCRP-HDRA and by support from the California Women’s Auxiliary to the Veterans of Foreign Wars.

Disclosures

Michael McClelland and Dan Mercola are the founders of a company, Proveri, Inc., which has an interest in biomarkers for prostate cancer, including diagnosis and prognosis. The participation of MM and DAM in this work and supporting grants has been disclosed to and approved by the UCI Conflict of Interest Committee.

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Authors and Affiliations

  1. Department of Botany and Plant Sciences, University of Califorania, Riverside, CA, 92521, USA

    Zhenyu Jia Ph.D., Chung Lee Ph.D. & Dan Mercola M.D., Ph.D.

  2. Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, 92697-4800, USA

    Zhenyu Jia Ph.D., Chung Lee Ph.D. & Dan Mercola M.D., Ph.D.

  3. Department of Urology, University of Calinfornia Irvine, Orange, CA, 92868, USA

    Xiaolin Zi M.D., Ph.D.

  4. Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA, 92697, USA

    Michael McClelland Ph.D.

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  1. Zhenyu Jia Ph.D.
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  2. Chung Lee Ph.D.
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  3. Xiaolin Zi M.D., Ph.D.
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  4. Michael McClelland Ph.D.
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  5. Dan Mercola M.D., Ph.D.
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Corresponding author

Correspondence to Dan Mercola M.D., Ph.D. .

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Editors and Affiliations

  1. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Brian D. Robinson

  2. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Juan Miguel Mosquera

  3. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Jae Y. Ro

  4. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Mukul Divatia

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Jia, Z., Lee, C., Zi, X., McClelland, M., Mercola, D. (2018). Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma. In: Robinson, B., Mosquera, J., Ro, J., Divatia, M. (eds) Precision Molecular Pathology of Prostate Cancer. Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-64096-9_16

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  • DOI: https://doi.org/10.1007/978-3-319-64096-9_16

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