Abstract
Therapy for gastroesophageal reflux disease and hiatus hernia remains unsatisfactory. About 40% of patients are partial responders to proton-pump inhibitors, and even high dose escalation may be inadequate to maintain in a symptom-free state individuals with a mechanically defective lower esophageal sphincter and volume regurgitation [1]. Furthermore, there are growing concerns over the long-term impact of chronic acid suppression on multiple metabolic and physiologic pathways, and there is evidence that patients suffering from uncontrolled esophageal acid exposure may progress to serious complications of the disease, such as pulmonary aspiration and fibrosis, esophagitis and peptic stricture, and Barrett’s metaplasia, the leading risk factor for esophageal adenocarcinoma [2].
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Bonavina, L., Sironi, A., Asti, E. (2018). Magnetic Sphincter Augmentation for Symptomatic Small Hiatus Hernia. In: Memon, M. (eds) Hiatal Hernia Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-64003-7_8
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DOI: https://doi.org/10.1007/978-3-319-64003-7_8
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