Advances in Vaccine Technology



Human papillomaviruses (HPVs) are the causative agent for recurrent respiratory papillomatosis, cancer of the cervix, and squamous cell carcinoma of the head and neck. Vaccines are available to prevent infection with several of the HPV types that are responsible for causing these serious diseases. This chapter discusses the development, successes, and limitations of these prophylactic L1-based vaccines. Potential for L2-based vaccines to provide broad coverage to prevent infection with many HPV types is also discussed. Finally, research into treatment of established HPV infection and resultant disease using therapeutic vaccines is outlined.


Human papillomavirus Vaccine Gardasil Cervarix Recurrent respiratory papillomatosis 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Julie Ahn
    • 1
  • Simon R. A. Best
    • 1
  • David E. Tunkel
    • 1
  1. 1.Department of Otolaryngology—Head and Neck SurgeryJohns Hopkins University School of MedicineBaltimoreUSA

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