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Gold Nanoparticles in Molecular Diagnostics and Molecular Therapeutics

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Metal Nanoparticles in Pharma

Abstract

Gold nanoparticles, due to their unique physicochemical properties, are among the most widely used nanoscale-based platforms for molecular diagnostics . The intrinsic chemical stability and apparent lack of toxicity have also prompted for application in therapeutics, e.g., for imaging modalities and as vectorization strategies for molecular modulators, i.e., gene silencing, specific targeting of cellular pathways, etc. Because of their common molecular ground, these approaches have been synergistically coupled together into molecular theranostic systems that allow for radical new in vivo diagnostics modalities with simultaneous tackling of molecular disequilibria leading to disease. Despite this tremendous potential, gold nanoparticle-based systems still have to make their effective translation to the clinics. This chapter focuses on the use of gold nanoparticles for molecular diagnostics and molecular therapeutics and their application in theranostics . Attention is paid to those systems that have moved toward the clinics.

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Abbreviations

AIE:

Aggregation-induced emission

AuNRs:

Gold nanorods

CT:

Computed tomography

DLS:

Dynamic light scattering

DOX:

Doxorubicin

EPR:

Enhanced permeability and retention effect

LFBs:

Lateral flow biosensor

LSPR:

Localized surface plasmon resonance

MTBC:

Mycobacterium tuberculosis complex

NASBA:

Nucleic acid sequence-based amplification

PA:

Photoacoustic imaging

PNB:

Plasmonic nanobubbles

QCM:

Quartz-crystal microbalance

SERS:

Surface-enhanced Raman scattering

siRNA:

Small interfering RNA

SNP:

Single nucleotide polymorphism

SPR:

Surface plasmon resonance

TPL:

Two-photon luminescence

US:

Ultrasounds

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Acknowledgments

The authors acknowledge Fundação para a Ciência e Tecnologia (FCT/MEC) for funding, UCIBIO (UID/Multi/04378/2013), co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728), WaterJPI/0003/2013, and PD/BD/105734/2014 for PP.

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Authors and Affiliations

  1. UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516, Caparica, Portugal

    Ana S. Matias, Fábio F. Carlos, P. Pedrosa, Alexandra R. Fernandes & Pedro V. Baptista

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  1. Ana S. Matias
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  2. Fábio F. Carlos
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  3. P. Pedrosa
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  4. Alexandra R. Fernandes
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  5. Pedro V. Baptista
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Corresponding author

Correspondence to Pedro V. Baptista .

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Editors and Affiliations

  1. Nanobiotechnology laboratory, Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, India

    Mahendra Rai, Ph.D

  2. Institute of Pharmacy, Department Pharmaceutics, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin, Germany

    Ranjita Shegokar, Ph.D

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Matias, A.S., Carlos, F.F., Pedrosa, P., Fernandes, A.R., Baptista, P.V. (2017). Gold Nanoparticles in Molecular Diagnostics and Molecular Therapeutics. In: Rai, Ph.D, M., Shegokar, Ph.D, R. (eds) Metal Nanoparticles in Pharma. Springer, Cham. https://doi.org/10.1007/978-3-319-63790-7_16

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