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Iron Oxide Magnetic Nanoparticles in Photodynamic Therapy: A Promising Approach Against Tumor Cells

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Metal Nanoparticles in Pharma

Abstract

Iron oxide magnetic nanoparticles have been extensively employed in biomedical applications due to their biocompatibility, small size, ability to surface functionalization, superparamagnetism behavior, and targeting properties. Upon the application of external magnetic field , iron oxide nanoparticles can be guided to the target site of application, minimizing possible side effects to nontarget tissues. Recently, several papers describe the combination of iron oxide magnetic nanoparticles with photosensitizer (PS) molecules for photodynamic therapy (PDT). PDT is a clinical treatment based on the administration of a photosensitizer to the tumor site, which under the irradiation with visible-near-infrared light generates reactive oxygen species (ROS ) able to cause deleterious effects to the treated tumor site. The main disadvantage of PDT is the lack of selectivity; therefore, the combination of magnetic iron oxide nanoparticles with photosensitizer is a new and promising approach in PDT. In this direction, this chapter discusses the recent advantages in the design and applications of magnetic iron oxide nanoparticles in conjugation with photosensitizer in PDT to combat cancer .

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Abbreviations

1O2 :

Singlet oxygen

3O2 :

Triplet oxygen

AHP:

Hyaluronic acid

AIPcS4:

Tetrasulfonic phthalocyanine aluminum

Ce6:

Chlorin e6

CSQ:

Chitosan quaternary ammonium

DOX:

Doxorubicin

Eca-109:

Esophageal squamous carcinoma

EPR:

Enhanced permeability and retention

ESIONs:

Extremely small iron oxide nanoparticles

FDA:

Food and Drug Administration

Fe3O4 :

Magnetite

HeLa:

Human cervical cancer cell line

HMNSs:

Hollow magnetic nanospheres

HP:

Hematoporphyrin

IC50 :

Maximal inhibitory concentration

IONCs:

Iron oxide nanoclusters

IR820:

Indocyanine green

Jurkat:

Human T-cell leukemia cells

LED:

Light-emitting diode

MCF-7:

Human breast cancer cells

MDA-MB-231:

Breast cancer

MLs:

Magnetoliposomes

MNCs:

Magnetic nanoclusters

mSiO2 :

Mesoporous silica

NIH3T3:

Mouse embryonic fibroblast

NRI:

Near infrared

OA:

Oleic acid

PC-3:

Human prostate cancer

PDT:

Photodynamic therapy

PEG:

Polyethylene glycol

pheoA:

Pheophorbide A

PHPP:

2,7,12,18-Tetramethyl-3,8-di(1-propoxyethyl)-12,17-bis-(3-hydroxypropyl) porphyrin

PMNs:

Magnetic nanogrenades

PpIX:

Protoporphyrin IX

PS:

Photosensitizer

RGD:

Integrin-binding cell adhesive peptide

rGO:

Reduced graphene oxide

ROS :

Reactive oxygen species

S-180:

Sarcoma cells

SK-OV-3:

Ovarian cancer cells

SPIO:

Superparamagnetic iron oxide

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Authors and Affiliations

  1. Human and Natural Sciences Center, Federal University of ABC, UFABC, Av dos Estados, 5001. Bairro Bangú, Santo André, SP, 09210-580, Brazil

    Amedea B. Seabra

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  1. Amedea B. Seabra
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Correspondence to Amedea B. Seabra .

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Editors and Affiliations

  1. Nanobiotechnology laboratory, Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, India

    Mahendra Rai, Ph.D

  2. Institute of Pharmacy, Department Pharmaceutics, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin, Germany

    Ranjita Shegokar, Ph.D

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Seabra, A.B. (2017). Iron Oxide Magnetic Nanoparticles in Photodynamic Therapy: A Promising Approach Against Tumor Cells. In: Rai, Ph.D, M., Shegokar, Ph.D, R. (eds) Metal Nanoparticles in Pharma. Springer, Cham. https://doi.org/10.1007/978-3-319-63790-7_1

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