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The Scientific Rationale to Apply Plasma Rich in Growth Factors in Joint Tissue Pathologies: Knee Osteoarthritis

  • Padilla S. 
  • Anitua E. 
  • Fiz N. 
  • Pompei O. 
  • Azofra J. 
  • Sánchez M. 
Chapter

Summary

Knee osteoarthritis (KOA) is a mechanically induced, cytokine and enzyme-mediated disorder with different biochemical, inflammatory, and genetic signatures undergoing distinct phases and phenotypes, and encompassing all joint tissues, with pain and inflammation as the clinical and biochemical hallmarks of the disease.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Padilla S. 
    • 3
    • 4
    • 5
  • Anitua E. 
    • 3
    • 4
    • 5
  • Fiz N. 
    • 1
  • Pompei O. 
    • 1
  • Azofra J. 
    • 1
  • Sánchez M. 
    • 1
    • 2
  1. 1.Arthroscopic Surgery UnitHospital Vithas San JoseVitoria-GasteizSpain
  2. 2.Advanced Biological therapy UnitHospital Vithas San JoséVitoria-GasteizSpain
  3. 3.BTI Biotechnology InstituteVitoriaSpain
  4. 4.Eduardo Anitua Foundation for Biomedical ResearchVitoria-GasteizSpain
  5. 5.University Institute for Regenerative Medicine and Oral Implantology (UIRMI) from the University of Basque Country (UPV/EHU)Vitoria-GasteizSpain

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