Platelets at the Interface between Inflammation and Tissue Repair

Summary

Blood platelets are produced in large numbers from megakaryocytes in the bone marrow. Anucleate, their principal role is to prevent blood loss on vascular injury and to promote tissue repair, and for this they adhere, aggregate and secrete a wide variety of metabolites and biologically active proteins. The latter are stored in organelles that undergo exocytosis when platelets are stimulated.