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On-Demand Controlled Drug Delivery

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Advances in Personalized Nanotherapeutics

Abstract

Spatial and temporal control of drug delivery is of prime importance for establishing the therapeutic compliance of drugs for various diseases. Conventional approaches to drug delivery for temporal control of drug delivery include encapsulation, entrapment and conjugation to polymeric materials for obtaining the controlled release. Several macro, micro and nanoformulations have been researched and commercialized for producing controlled release of drugs. Apart from the control over the rate of release, a regional delivery would be highly desirable for increasing the efficacy of the drugs and reducing the undue side effects pertaining to the therapy. Some developments in region specific delivery have been utilizing physiological differences of various sites in the body. Topical formulations have been extensively explored for their region specific delivery due to ease of access of these organs like eye, ear, nasal, oral, vaginal and rectal cavities or parts of gastro-intestinal tract like mouth, stomach, intestine and colon. Several sites of the body have not been reached using drug delivery formulations to selectively deliver the drugs to particular organs due to several physiological barriers. Recent developments and approaches in material chemistry, novel polymers, and technology advancements have led to new avenues in the development of nano/micro-carriers or materials for on-demand controlled drug delivery or stimuli responsive drug delivery. On-demand drug release although complex has become possible due to materials which recognize the microenvironments and react in a dynamic way altering properties to cause release of encapsulated drugs within. The current chapter reviews different approaches of developing on-demand drug release using different materials and techniques.

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Acknowledgements

Rahul Dev Jayant would like to acknowledge financial support from Herbert Wertheim College of Medicine Pilot funding grant (# 800008542); The Campbell Foundation grant (# 800008886); and other support from Center for Personalized Nanomedicine (CPNM) and Institute of Neuro-Immune Pharmacology (INIP) from Department of Immunology, Florida International University (FIU). Abhijeet Joshi acknowledges the INSPIRE Faculty award and fellowship provided by Department of Science and Technology, Government of India. Authors would like acknowledge financial support from DBT and SERB.

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Authors and Affiliations

  1. Centre for Biosciences and Bio-medical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, 453552, India

    Abhijeet Joshi

  2. Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India

    Rashmi Chaudhari

  3. Center for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA

    Rahul Dev Jayant

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  1. Abhijeet Joshi
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  2. Rashmi Chaudhari
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Correspondence to Abhijeet Joshi or Rahul Dev Jayant .

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Editors and Affiliations

  1. Department of Immunology, Center for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA

    Ajeet Kaushik

  2. Department of Immunology, Center for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA

    Rahul Dev Jayant

  3. Department of Immunology, Center for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA

    Madhavan Nair

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Joshi, A., Chaudhari, R., Jayant, R.D. (2017). On-Demand Controlled Drug Delivery. In: Kaushik, A., Jayant, R., Nair, M. (eds) Advances in Personalized Nanotherapeutics . Springer, Cham. https://doi.org/10.1007/978-3-319-63633-7_9

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