Abstract
Hydrogels are the three dimensional crosslinked network of polymeric materials, which have the ability to respond and adapt to the surrounding environment inside the human body. Hydrogels are the upcoming class of biomaterials, which act as excellent drug delivery systems. These materials have important characteristic feature that they respond to various external stimuli like pH, light, temperature, magnetic field, electric field and pressure. Present chapter gives a broad overview of the recent hydrogels used for drug delivery using various external stimuli. Concluding remarks and viewpoints for the future development of stimuli responsive hydrogels are addressed.
References
Vashist A, Ahmad S. Hydrogels: smart materials for drug delivery. Orient J Chem. 2013;29:861–70.
Vashist A, Vashist A, Gupta Y, Ahmad S. Recent advances in hydrogel based drug delivery systems for the human body. J Mater Chem B. 2014;2:147–66.
Gupta P, Vermani K, Garg S. Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discov Today. 2002;7:569–79.
Jing G, Wang L, Yu H, Amer WA, Zhang L. Recent progress on study of hybrid hydrogels for water treatment. Colloids Surf A Physicochem Eng Asp. 2013;416:86–94.
Hoare TR, Kohane DS. Hydrogels in drug delivery: progress and challenges. Polymer. 2008;49:1993–2007.
Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chem Rev. 1999;99:3181–98.
Mura S, Nicolas J, Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nat Mater. 2013;12:991–1003.
Lin C-C, Metters AT. Hydrogels in controlled release formulations: network design and mathematical modeling. Adv Drug Deliv Rev. 2006;58:1379–408.
Vashist A, Ahmad S. Hydrogels in tissue engineering: scope and applications. Curr Pharm Biotechnol. 2015;16:606–20.
Wei Q, Xu M, Liao C, Wu Q, Liu M, Zhang Y, et al. Printable hybrid hydrogel by dual enzymatic polymerization with superactivity. Chem Sci. 2016;7:2748–52.
Li L, Shi Y, Pan L, Shi Y, Yu G. Rational design and applications of conducting polymer hydrogels as electrochemical biosensors. J Mater Chem B. 2015;3:2920–30.
Merino S, MartÃn C, Kostarelos K, Prato M, Vázquez E. Nanocomposite hydrogels: 3D polymer–nanoparticle synergies for on-demand drug delivery. ACS Nano. 2015;9:4686–97.
Tabujew I, Peneva K. Functionalization of cationic polymers for drug delivery applications. In: Samal SK, Dubruel P, editors. Cationic polymers in regenerative medicine. Cambridge: Royal Society of Chemistry; 2014.
Watkins KA, Chen R. pH-responsive, lysine-based hydrogels for the oral delivery of a wide size range of molecules. Int J Pharm. 2015;478:496–503.
Li L, Gu J, Zhang J, Xie Z, Lu Y, Shen L, et al. Injectable and biodegradable pH-responsive hydrogels for localized and sustained treatment of human fibrosarcoma. ACS Appl Mater Interfaces. 2015;7:8033–40.
Song HS, Kwon OS, Kim J-H, Conde J, Artzi N. 3D hydrogel scaffold doped with 2D graphene materials for biosensors and bioelectronics. Biosens Bioelectron. 2017;89:187–200.
Campbell S, Maitland D, Hoare T. Enhanced pulsatile drug release from injectable magnetic hydrogels with embedded thermosensitive microgels. ACS Macro Lett. 2015;4:312–6.
Li Y, Huang G, Zhang X, Li B, Chen Y, Lu T, et al. Magnetic hydrogels and their potential biomedical applications. Adv Funct Mater. 2013;23:660–72.
Sapir Y, Cohen S, Friedman G, Polyak B. The promotion of in vitro vessel-like organization of endothelial cells in magnetically responsive alginate scaffolds. Biomaterials. 2012;33:4100–9.
Zhang Y, Yang B, Zhang X, Xu L, Tao L, Li S, et al. A magnetic self-healing hydrogel. Chem Commun. 2012;48:9305–7.
Liu T-Y, Hu S-H, Liu T-Y, Liu D-M, Chen S-Y. Magnetic-sensitive behavior of intelligent ferrogels for controlled release of drug. Langmuir. 2006;22:5974–8.
Szabo D, Szeghy G, Zrinyi M. Shape transition of magnetic field sensitive polymer gels. Macromolecules. 1998;31:6541–8.
Snyder R, Nguyen V, Ramanujan R. Design parameters for magneto-elastic soft actuators. Smart Mater Struct. 2010;19:055017.
Fuhrer R, Athanassiou EK, Luechinger NA, Stark WJ. Crosslinking metal nanoparticles into the polymer backbone of hydrogels enables preparation of soft, magnetic field-driven actuators with muscle-like flexibility. Small. 2009;5:383–8.
Liu T-Y, Hu S-H, Liu D-M, Chen S-Y, Chen I-W. Biomedical nanoparticle carriers with combined thermal and magnetic responses. Nano Today. 2009;4:52–65.
Kost J, Wolfrum J, Langer R. Magnetically enhanced insulin release in diabetic rats. J Biomed Mater Res. 1987;21:1367–73.
Ang K, Venkatraman S, Ramanujan R. Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy. Mater Sci Eng C. 2007;27:347–51.
Le Renard P-E, Jordan O, Faes A, Petri-Fink A, Hofmann H, Ruefenacht D, et al. The in vivo performance of magnetic particle-loaded injectable, in situ gelling, carriers for the delivery of local hyperthermia. Biomaterials. 2010;31:691–705.
McKenzie M, Betts D, Suh A, Bui K, Kim LD, Cho H. Hydrogel-based drug delivery systems for poorly water-soluble drugs. Molecules. 2015;20:20397–408.
Nguyen MK, Lee DS. Injectable biodegradable hydrogels. Macromol Biosci. 2010;10:563–79.
Wu Q, Wang N, He T, Shang J, Li L, Song L, et al. Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model. Sci Rep. 2015;5:13553.
Fusco S, Borzacchiello A, Netti P. Perspectives on: PEO-PPO-PEO triblock copolymers and their biomedical applications. J Bioact Compat Polym. 2006;21:149–64.
Jeong B, Bae YH, Kim SW. In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof. J Biomed Mater Res. 2000;50:171–7.
Yan S, Zhang X, Zhang K, Di H, Feng L, Li G, et al. Injectable in situ forming poly (l-glutamic acid) hydrogels for cartilage tissue engineering. J Mater Chem B. 2016;4:947–61.
Tahrir FG, Ganji F, Ahooyi TM. Injectable Thermosensitive chitosan/Glycerophosphate-based hydrogels for tissue engineering and drug delivery applications: a review. Recent Pat Drug Deliv Formul. 2015;9:107–20.
Cho J, Heuzey M-C, Bégin A, Carreau PJ. Physical gelation of chitosan in the presence of β-glycerophosphate: the effect of temperature. Biomacromolecules. 2005;6:3267–75.
Cho J, Heuzey M-C, Bégin A, Carreau PJ. Chitosan and glycerophosphate concentration dependence of solution behaviour and gel point using small amplitude oscillatory rheometry. Food Hydrocoll. 2006;20:936–45.
Zhou HY, Jiang LJ, Cao PP, Li JB, Chen XG. Glycerophosphate-based chitosan thermosensitive hydrogels and their biomedical applications. Carbohydr Polym. 2015;117:524–36.
Crompton K, Goud J, Bellamkonda R, Gengenbach T, Finkelstein D, Horne M, et al. Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. Biomaterials. 2007;28:441–9.
Elad D, Wolf M, Keck T. Air-conditioning in the human nasal cavity. Respir Physiol Neurobiol. 2008;163:121–7.
Mygind N, Dahl R. Anatomy, physiology and function of the nasal cavities in health and disease. Adv Drug Deliv Rev. 1998;29:3–12.
Nazar H, Fatouros DG, van der Merwe SM, Bouropoulos N, Avgouropoulos G, Tsibouklis J, et al. Thermosensitive hydrogels for nasal drug delivery: the formulation and characterisation of systems based on N-trimethyl chitosan chloride. Eur J Pharm Biopharm. 2011;77:225–32.
Gou M, Li X, Dai M, Gong C, Wang X, Xie Y, et al. A novel injectable local hydrophobic drug delivery system: biodegradable nanoparticles in thermo-sensitive hydrogel. Int J Pharm. 2008;359:228–33.
Di J, Yao S, Ye Y, Cui Z, Yu J, Ghosh TK, et al. Stretch-triggered drug delivery from wearable elastomer films containing therapeutic depots. ACS Nano. 2015;9:9407–15.
Lee K, Cussler E, Marchetti M, McHugh M. Pressure-dependent phase transitions in hydrogels. Chem Eng Sci. 1990;45:766–7.
Zhong X, Wang Y-X, Wang S-C. Pressure dependence of the volume phase-transition of temperature-sensitive gels. Chem Eng Sci. 1996;51:3235–9.
Rosenthal A, Barry JJ, Sahatjian R. Triggered release hydrogel drug delivery system. Google Patents, 2003.
Yuk SH, Cho SH, Lee HB. Electric current-sensitive drug delivery systems using sodium alginate/polyacrylic acid composites. Pharm Res. 1992;09:955–7.
Kwon IC, Bae YH, Kim SW. Electrically credible polymer gel for controlled release of drugs. Nature. 1991;354:291.
Delgado-Charro MB, Guy RH. Transdermal iontophoresis for controlled drug delivery and non-invasive monitoring. STP Pharma Sci. 2001;11:404–14.
Vanbever R, Preat V. In vivo efficacy and safety of skin electroporation. Adv Drug Deliv Rev. 1999;35:77–88.
Murdan S. Electro-responsive drug delivery from hydrogels. J Control Release. 2003;92:1–17.
Tanaka T, Nishio I, Sun S-T, Ueno-Nishio S. Collapse of gels in an electric field. Science. 1982;218:467–9.
Tomer R, Dimitrijevic D, Florence AT. Electrically controlled release of macromolecules from cross-linked hyaluronic acid hydrogels. J Control Release. 1995;33:405–13.
Acknowledgements
Authors acknowledge NIH grants: RO1DA027049, R21MH 101,025, RO1DA 034547, R01DA037838, and 1R01DA040537.
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Vashist, A., Kaushik, A., Jayant, R.D., Vashist, A., Ghosal, A., Nair, M. (2017). Hydrogels: Stimuli Responsive to on-Demand Drug Delivery Systems. In: Kaushik, A., Jayant, R., Nair, M. (eds) Advances in Personalized Nanotherapeutics . Springer, Cham. https://doi.org/10.1007/978-3-319-63633-7_8
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