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Nanoformulations for Therapeutics

  • PSS RaoEmail author
  • Christopher RT Stang
Chapter
  • 394 Downloads

Abstract

In the recent decade and a half, research in the area of nanoformulation has vastly expanded, including research dedicated to discovery of novel drugs as well as the reformulation of tried and tested drugs. The utilization of nanoformulations has yielded positive results in areas that have typically been regarded as therapeutic challenges. Nanoformulations, by in large, aim to alter the pharmacokinetic properties of a medication, improving absorption, distribution, selectivity, and altering metabolism. The blood-brain barrier has largely been an obstacle in the treatment of neurodegenerative disorders and tumors located within the central nervous system. Several drugs have been discovered that are effective in treating these pathologies. However, reaching appropriate therapeutic concentration in the central nervous system, without excessive systemic drug concentrations and side effects, has remained a limitation to these medications’ efficacy. Nanoformulating such medications has yielded improved drug delivery and efficacy to the central nervous system despite the influences of multi-drug resistance proteins. Various methods of nanoformulation have been employed to facilitate the selective transport of drugs across the blood-brain barrier including the use of focused ultrasound, magnetic targeting, macrophage loaded drug formulations, carbon nanotubules, polymer coatings, and receptor-mediated transcytosis. These formulations have resulted in the efficient delivery of drug molecules, proteins, and DNA to the relevant tissue in the central nervous system. The continued research into nanoformulations allows for the development of more selective and effective medications while possibly salvaging medications that were deemed not useful due to their sub-therapeutic properties.

Keywords

Nanoformulations Personalized nanotherapeutics Nano-biotechnology 

Notes

Acknowledgment

The authors would like to thank the original authors and Elsevier for providing the copyrights permission to use Figs. 6.1 and 6.2 included in this book chapter. The authors would also like to thank the original authors and the American Chemical Society for providing the copyrights permission to use Fig. 6.3 and Fig. 6.4.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Pharmaceutical Sciences, College of PharmacyThe University of FindlayFindlayUSA

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