Skip to main content
SpringerLink
Log in

Bone Substitute: Alveolar Bone Grafting (ABG) with rhBMP-2 (Recombinant Bone Morphogenic Protein-2)

  • Chapter
  • First Online:
Cleft Lip and Palate Treatment

  • 2243 Accesses

Abstract

Alveolar bone grafting was first introduced to Brazil by the Bauru Cleft Team in 1993, brought from Oslo, Norway (Abyholm et al. 1981a). Since that time, the use of autologous bone grafting harvested from the iliac crest using Boyne’s technique has become the gold standard for the rehabilitation of the vast majority of cleft patients worldwide (Boyne and Sands 1972). Secondary alveolar bone grafting is ideally performed at 8–10 years of age, when dental development is finishing and the canine is partially formed, with a root of at least 2/3 of final size, ready to erupt into the maxilla. Preoperatively, the use of transverse maxillary expansion and orthodontics for dental alignment facilitates greatly the alveolar bone grafting procedure (Abyholm et al. 1981a, b).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abyholm FE, Bergland O, Semb G. Secondary bone grafting of alveolar clefts. A surgical/orthodontic treatment enabling a non-prosthodontic rehabilitation in cleft lip and palate patients. Scand J Plast Reconstr Surg. 1981a;15(2):127–40.

    Article  CAS  PubMed  Google Scholar 

  • Abyholm FE, Borchgrevink HC, Eskeland G. Cleft lip and palate in Norway. III. Surgical treatment of CLP patients in Oslo 1954-75. Scand J Plast Reconstr Surg. 1981b;15(1):15–28.

    Article  CAS  PubMed  Google Scholar 

  • Alonso N, Tanikawa DY, Freitas Rda S, Canan L Jr, Ozawa TO, Rocha DL. Evaluation of maxillary alveolar reconstruction using a resorbable collagen sponge with recombinant human bone morphogenetic protein-2 in cleft lip and palate patients. Tissue Eng Part C Methods. 2010;16(5):1183–9.

    Article  CAS  PubMed  Google Scholar 

  • Alonso N, Risso GH, Denadai R, Raposo-Amaral CE. Effect of maxillary alveolar reconstruction on nasal symmetry of cleft lip and palate patients: a study comparing iliac crest bone graft and recombinant human bone morphogenetic protein-2. J Plast Reconstr Aesthet Surg. 2014;67(9):1201–8.

    Article  PubMed  Google Scholar 

  • Baskin DS, Ryan P, Sonntag V, Westmark R, Widmayer MA. A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR allograft ring and the ATLANTIS anterior cervical plate. Spine (Phila Pa 1976). 2003;28(12):1219–24. discussion 25

    Google Scholar 

  • Boden SD, Zdeblick TA, Sandhu HS, Heim SE. The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine (Phila Pa 1976). 2000;25(3):376–81.

    Article  CAS  Google Scholar 

  • Boyne PJ, Sands NR. Secondary bone grafting of residual alveolar and palatal clefts. J Oral Surg. 1972;30(2):87–92.

    CAS  PubMed  Google Scholar 

  • Bueno DF, Kerkis I, Costa AM, Martins MT, Kobayashi GS, Zucconi E, et al. New source of muscle-derived stem cells with potential for alveolar bone reconstruction in cleft lip and/or palate patients. Tissue Eng Part A. 2009;15(2):427–35.

    Article  CAS  PubMed  Google Scholar 

  • Canan LW Jr, da Silva FR, Alonso N, Tanikawa DY, Rocha DL, Coelho JC. Human bone morphogenetic protein-2 use for maxillary reconstruction in cleft lip and palate patients. J Craniofac Surg. 2012;23(6):1627–33.

    Article  PubMed  Google Scholar 

  • Carstens MH, Chin M, Li XJ. In situ osteogenesis: regeneration of 10-cm mandibular defect in porcine model using recombinant human bone morphogenetic protein-2 (rhBMP-2) and Helistat absorbable collagen sponge. J Craniofac Surg. 2005a;16(6):1033–42.

    Article  PubMed  Google Scholar 

  • Carstens MH, Chin M, Ng T, Tom WK. Reconstruction of #7 facial cleft with distraction-assisted in situ osteogenesis (DISO): role of recombinant human bone morphogenetic protein-2 with Helistat-activated collagen implant. J Craniofac Surg. 2005b;16(6):1023–32.

    Article  PubMed  Google Scholar 

  • Chin M, Ng T, Tom WK, Carstens M. Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts. J Craniofac Surg. 2005;16(5):778–89.

    Article  PubMed  Google Scholar 

  • Clarke A, Flowers MJ, Davies AG, Fernandes J, Jones S. Morbidity associated with anterior iliac crest bone graft harvesting in children undergoing orthopaedic surgery: a prospective review. J Child Orthop. 2015;9(5):411–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • David L, Argenta L, Fisher D. Hydroxyapatite cement in pediatric craniofacial reconstruction. J Craniofac Surg. 2005;16(1):129–33.

    Article  PubMed  Google Scholar 

  • Daw JL Jr, Patel PK. Management of alveolar clefts. Clin Plast Surg. 2004;31(2):303–13.

    Article  PubMed  Google Scholar 

  • Hall HD, Posnick JC. Early results of secondary bone grafts in 106 alveolar clefts. J Oral Maxillofac Surg. 1983;41(5):289–94.

    Article  CAS  PubMed  Google Scholar 

  • Leal CR, Calvo AM, de Souza Faco RA, da Cunha Bastos Junior JC, Yaedu RY, da Silva Dalben G, et al. Evolution of postoperative edema in alveolar graft performed with bone morphogenetic protein (rhBMP-2). Cleft Palate Craniofac J. 2015;52(5):e168–75.

    Article  PubMed  Google Scholar 

  • Lima Junior JEAN. O uso de rhBMP-2 para enxerto osseo alveolar em fissurados. Relação custo efetividade. 51 Congresso Brasileiro de Cirurgia Plastic. Bahia, Brasil; 2014.

    Google Scholar 

  • de Mendonca CA, Bueno DF, Martins MT, Kerkis I, Kerkis A, Fanganiello RD, et al. Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells. J Craniofac Surg. 2008;19(1):204–10.

    Article  Google Scholar 

  • Ochs MW. Alveolar cleft bone grafting (part II): secondary bone grafting. J Oral Maxillofac Surg. 1996;54(1):83–8.

    Article  CAS  PubMed  Google Scholar 

  • Raposo-Amaral CE, Bueno DF, Almeida AB, Jorgetti V, Costa CC, Gouveia CH, et al. Is bone transplantation the gold standard for repair of alveolar bone defects? J Tissue Eng. 2014;5:2041731413519352.

    Article  PubMed  PubMed Central  Google Scholar 

  • Raposo-Amaral CE, Denadai R, Alonso N. Three-dimensional changes of maxilla after secondary alveolar cleft repair: differences between rhBMP-2 and autologous iliac crest bone grafting. Plast Reconstr Surg Glob Open. 2015;3(7):e451.

    Article  PubMed  PubMed Central  Google Scholar 

  • Raposo-Amaral CE, Denadai R, Alonso N. Three-dimensional upper lip and nostril sill changes after cleft alveolus reconstruction using autologous bone grafting versus recombinant human bone morphogenetic protein-2. J Craniofac Surg. 2016;27(4):913–8.

    Article  PubMed  Google Scholar 

  • Tanikawa DY, Aguena M, Bueno DF, Passos-Bueno MR, Alonso N. Fat grafts supplemented with adipose-derived stromal cells in the rehabilitation of patients with craniofacial microsomia. Plast Reconstr Surg. 2013;132(1):141–52.

    Article  CAS  PubMed  Google Scholar 

  • Tissiani LA, Alonso N. A prospective and controlled clinical trial on stromal vascular fraction enriched fat grafts in secondary breast reconstruction. Stem Cells Int. 2016;2016:2636454.

    Article  CAS  PubMed  Google Scholar 

  • Urist MR. Bone: formation by autoinduction. Science. 1965;150(3698):893–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Divisao de Cirurgia Plastica e Queimaduras, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Nivaldo Alonso M.D., Ph.D.

  2. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA

    Julia Amundson B.S.

Authors
  1. Nivaldo Alonso M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julia Amundson B.S.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nivaldo Alonso M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. University of São Paulo Medical School, São Paulo, São Paulo, Brazil

    Nivaldo Alonso

  2. SOBRAPAR Hospital, Campinas, São Paulo, Brazil

    Cassio Eduardo Raposo-Amaral

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Alonso, N., Amundson, J. (2018). Bone Substitute: Alveolar Bone Grafting (ABG) with rhBMP-2 (Recombinant Bone Morphogenic Protein-2). In: Alonso, N., Raposo-Amaral, C. (eds) Cleft Lip and Palate Treatment. Springer, Cham. https://doi.org/10.1007/978-3-319-63290-2_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-63290-2_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-63289-6

  • Online ISBN: 978-3-319-63290-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation