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Obesity and Brain Function pp 191–210Cite as

Multiple Sclerosis: Implications of Obesity in Neuroinflammation

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Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 19))

Abstract

Since the discovery of the remarkable properties of adipose tissue as a metabolically active organ, several evidences on the possible link between obesity and the pathogenesis of multiple sclerosis (MS) have been gathered. Obesity in early life, mainly during adolescence, has been proposed as a relevant risk factor for late MS development. Moreover, once MS is initiated, obesity can contribute to increase disease severity by negatively influencing disease progress. Despite the fact that clinical data are not yet conclusive, many biochemical links have been recently disclosed. The “low-grade inflammation” that characterizes obesity can lead to neuroinflammation through different mechanisms, including choroid plexus and blood–brain barrier disruption. Furthermore, it is well known that resident immune cells of central nervous system and peripheral immune cells are involved in the pathogenesis of MS, and adipokines and neuropeptides such as neuropeptide Y may mediate the cross talk between them.

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Authors and Affiliations

  1. Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

    Ana Margarida Novo & Sónia Batista

  2. Faculty of Medicine, University of Coimbra, Coimbra, Portugal

    Sónia Batista

  3. CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

    Sónia Batista

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  1. Ana Margarida Novo
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  2. Sónia Batista
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Correspondence to Sónia Batista .

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  1. Institute of Physiology, Institute for Biomedical Imaging and Life Sciences—IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal

    Liliana Letra

  2. Institute of Physiology, Institute for Biomedical Imaging and Life Sciences—IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal

    Raquel Seiça

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Novo, A.M., Batista, S. (2017). Multiple Sclerosis: Implications of Obesity in Neuroinflammation. In: Letra, L., Seiça, R. (eds) Obesity and Brain Function. Advances in Neurobiology, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-319-63260-5_8

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