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Pulmonary Vasculature Redox Signaling in Health and Disease pp 179–194Cite as

Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 967))

Abstract

Although it is necessary and part of standard practice, supplemental oxygen (40–90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung.

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Authors and Affiliations

  1. Department of Anesthesiology, College of Medicine, Mayo Clinic, 4-184 W Jos SMH, 200 First St SW, Rochester, MN, 55905, USA

    Christina M. Pabelick M.D. & Michael A. Thompson

  2. Departments Physiology and Biomedical Engineering, College of Medicine, Mayo Clinic, 4-184 W Jos SMH, 200 First St SW, Rochester, MN, 55905, USA

    Christina M. Pabelick M.D. & Rodney D. Britt Jr Ph.D.

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  1. Christina M. Pabelick M.D.
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  2. Michael A. Thompson
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  3. Rodney D. Britt Jr Ph.D.
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Correspondence to Christina M. Pabelick M.D. .

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  1. Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA

    Yong-Xiao Wang

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Pabelick, C.M., Thompson, M.A., Britt, R.D. (2017). Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature. In: Wang, YX. (eds) Pulmonary Vasculature Redox Signaling in Health and Disease. Advances in Experimental Medicine and Biology, vol 967. Springer, Cham. https://doi.org/10.1007/978-3-319-63245-2_11

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